| Assay ID | Title | Year | Journal | Article |
|---|
| AID512066 | Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
| AID729942 | Solubility in human plasma | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins. |
| AID384963 | Inhibition of tubulin aggregation | 2008 | Journal of medicinal chemistry, May-08, Volume: 51, Issue:9
| Synthesis and biological activity of fluorinated combretastatin analogues. |
| AID1586362 | Antiproliferative activity against human HL60 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600477 | Induction of apoptosis in human CCRF-CEM cells assessed as accumulation at subG1 phase at antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 3.71%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600481 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 46%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID727503 | Cytotoxicity against human K562 cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
| Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. |
| AID1353745 | Induction of apoptosis in human A549 cells after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID273363 | Antiproliferative activity against human HT29 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID1600488 | Effect on DNA synthesis in human CCRF-CEM cells assessed as DNA synthesis level at 5 times IC50 incubated for 24 hrs by propidium iodide staining-based BrdU incorporation assay (Rvb = 52.13%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID273365 | Antiproliferative activity against human MKN45 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID273361 | Antiproliferative activity against human KB-VIN10 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID1600487 | Effect on DNA synthesis in human CCRF-CEM cells assessed as DNA synthesis level at IC50 incubated for 24 hrs by propidium iodide-staining based BrdU incorporation assay (Rvb = 52.13%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1353636 | Antiproliferative activity against human MDA-MB-231 cells after 3 days by coulter counting method | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1586363 | Antiproliferative activity against HMEC1 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1278674 | Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID1600474 | Therapeutic index, ratio of IC50 for human BJ cells to IC50 for human CCRF-CEM cells | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID727501 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
| Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. |
| AID443468 | Cytotoxicity against human MCF7 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24
| Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. |
| AID729939 | Antiproliferative activity against mouse Colon 26 cells assessed as inhibition of cell growth | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins. |
| AID1600493 | Inhibition of porcine brain tubulin polymerization at 10 umol measured every 60 secs by turbidometric assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1570322 | Antiviral activity against Zika virus infected in human HuH7 cells assessed as reduction in viral titer at 5 uM measured after 24 hrs by Cell-Titer Glo luminescent assay relative to control | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1570338 | Ratio of compound CC50 to CA4 CC50 for human HeLa cells measured after 72 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1353742 | Induction of apoptosis in human A549 cells at 100 nM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 28%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1353648 | Disruption of microtubule network in human A549 cells assessed as appearance of compressed and fragmented nuclei at 230 nM after 16 hrs by Hoechst staining based immunofluorescence assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1570327 | Antiviral activity against wild type Dengue virus serotype 2 infected in human HuH7 cells assessed as reduction in viral titer at 25 uM measured after 24 hrs by Cell-Titer Glo luminescent assay relative to control | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1600463 | Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600483 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 12.12%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID384964 | Antiproliferative activity against bovine microvascular endothelial cells | 2008 | Journal of medicinal chemistry, May-08, Volume: 51, Issue:9
| Synthesis and biological activity of fluorinated combretastatin analogues. |
| AID512064 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
| AID1570334 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1586358 | Antiproliferative activity against human HT-29 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600491 | Inhibition of porcine brain tubulin polymerization assessed as Vmax measured every 60 secs by turbidometric assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600489 | Effect on RNA synthesis in human CCRF-CEM cells assessed as RNA synthesis level at IC50 incubated for 24 hrs by propidium iodide staining-based BrdU incorporation assay (Rvb = 47.37%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID210312 | In vitro cytotoxic activity against human TSGH cell line of stomach carcinoma | 2004 | Journal of medicinal chemistry, May-20, Volume: 47, Issue:11
| Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. |
| AID384966 | Cytotoxic activity against human HT29 cells after 72 hrs by sulforhodamine B test | 2008 | Journal of medicinal chemistry, May-08, Volume: 51, Issue:9
| Synthesis and biological activity of fluorinated combretastatin analogues. |
| AID1353647 | Disruption of microtubule network in human A549 cells assessed as appearance of tubulin aggregates at 230 nM after 16 hrs by Hoechst staining based immunofluorescence assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1600472 | Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600480 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0/G1 phase at 5 times antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 40.89%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID512067 | Inhibition of tubulin polymerization in multidrug-resistant human HCT15 cells after 1 hr | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
| AID443467 | Cytotoxicity against human HeLa cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24
| Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. |
| AID1600470 | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID52669 | Growth inhibition of colon 26 adenocarcinoma cells by 50 %. | 1998 | Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
| Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships. |
| AID1353632 | Antiproliferative activity against human A549 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID247255 | Growth inhibition against human neuroblastoma cell line (SK-N-SH) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID1353633 | Antiproliferative activity against human HL60 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID480721 | Growth inhibition of Saccharomyces cerevisiae BY4741 at 300 uM up to 180 mins | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae. |
| AID1600467 | Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1586424 | Induction of apoptosis in human A549 cells at 50 uM after 20 to 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 16%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID480720 | Growth inhibition of Saccharomyces cerevisiae BY4741 at 150 uM up to 180 mins | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae. |
| AID1586360 | Antiproliferative activity against human HeLa cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1586425 | Antiangiogenic activity against HMEC1 cells after 20 hrs by tube formation assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID526513 | Antiproliferative activity against P-gp expressing multidrug-resistant human MDA-MB-231 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog. |
| AID1600469 | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1353663 | Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 60 nM after 20 hrs by propidium iodide staining based flow cytometry (Rvb = 66 +/- 1%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1586371 | Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 0.23 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 28 +/- 0.6%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600466 | Cytotoxicity against human K562-TAX cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1570329 | Inhibition of porcine tubulin polymerization at 10 uM preincubated at 37 degC for 30 mins followed by chilling to 0 degC and subsequent addition of GTP by microtiter plate based absorbance detection assay relative to control | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID512065 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
| AID84445 | In vitro cytotoxic activity against human HT-29 cell line of colorectal carcinoma | 2004 | Journal of medicinal chemistry, May-20, Volume: 47, Issue:11
| Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. |
| AID273362 | Antiproliferative activity against human H460 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID1586370 | Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 0.23 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 60 +/- 1%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600473 | Cytotoxicity against human MCR5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600475 | Therapeutic index, ratio of IC50 for HUVEC to IC50 for human HCT116 cells | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID225048 | Inhibitory activity against murine colon 26 adenocarcinoma cell | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
| Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides. |
| AID1353743 | Induction of apoptosis in human A549 cells at 10 nM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 28%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1586417 | Disruption of microtubule network in human A549 cells assessed as compressed and fragmented nuclei at 0.23 uM after 16 hrs by Hoechst staining based immunofluorescence microscopic method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600482 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 5 times antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 46%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID384965 | Cytotoxic activity against human NCI-H460 cells after 72 hrs by sulforhodamine B test | 2008 | Journal of medicinal chemistry, May-08, Volume: 51, Issue:9
| Synthesis and biological activity of fluorinated combretastatin analogues. |
| AID1353630 | Antiproliferative activity against human MCF7 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1600492 | Inhibition of tubulin polymerization in human HCT116 cells assessed as multipolar spindle formation at antiproliferative IC50 incubated for 24 hrs by DAPI staining based spinning disk confocal microscopic method | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1278675 | Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID1586361 | Antiproliferative activity against human A549 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID214690 | Inhibitory concentration required against MAP-rich tubulin polymerization | 2004 | Journal of medicinal chemistry, May-20, Volume: 47, Issue:11
| Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. |
| AID1353631 | Antiproliferative activity against human HeLa cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1600485 | Induction of mitotic block in human CCRF-CEM cells assessed as histone H3 Ser10 phosphorylation level at antiproliferative IC50 incubated for 48 hrs by flow cytometric analysis (Rvb = 0.97%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID273364 | Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID1278682 | Displacement of [3H]colchicine from bovine brain tubulin at 1 uM after 10 mins by scintillation counting analysis | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID1586364 | Antiproliferative activity against HEK293 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID761828 | Inhibition of tubulin (unknown origin) polymerization after 20 mins | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16
| Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity. |
| AID1570325 | Cytotoxicity against human HeLa cells harboring Dengue virus serotype 2 NS2B-NS3 protease assessed as reduction in cell viability after 72 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1600468 | Cytotoxicity against p53 deficient human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600464 | Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID480722 | Growth inhibition of Saccharomyces cerevisiae BY4741 at 450 uM up to 180 mins | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae. |
| AID1600471 | Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1353662 | Cell cycle arrest in human A549 cells assessed as accumulation at sub-G0 phase at 60 nM after 20 hrs by propidium iodide staining based flow cytometry (Rvb = 6.6 +/- 0.1%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1600479 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0/G1 phase at antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 40.89%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600490 | Effect on RNA synthesis in human CCRF-CEM cells assessed as RNA synthesis level at 5 times IC50 incubated for 24 hrs by propidium iodide staining-based BrdU incorporation assay (Rvb = 47.37%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1353634 | Antiproliferative activity against HMEC1 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1600494 | Inhibition of tubulin polymerization in human HCT116 cells assessed as disruption of mitotic spindle at antiproliferative IC50 incubated for 24 hrs by DAPI staining based spinning disk confocal microscopic method | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1353642 | Inhibition of calf brain tubulin polymerization after 60 mins by turbidimetric method | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID1353665 | Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 60 nM after 20 hrs by propidium iodide staining based flow cytometry (Rvb = 11 +/- 1%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID727504 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
| Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. |
| AID247232 | Growth inhibition against human prostate cell line (DU-145) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID247231 | Growth inhibition against human lung-NSC NCI-H460 cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID1570337 | Ratio of compound CC50 to CA4 CC50 for human HuH7 cells measured after 72 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1586423 | Induction of apoptosis in human A549 cells at 100 uM after 20 to 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 16%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1353664 | Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 60 nM after 20 hrs by propidium iodide staining based flow cytometry (Rvb = 16 +/- 1%) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID95844 | In vitro cytotoxic activity against human KB cell line of epidermoid carcinoma | 2004 | Journal of medicinal chemistry, May-20, Volume: 47, Issue:11
| Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. |
| AID1278670 | Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID273360 | Antiproliferative activity against human KB cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
| AID1586369 | Cell cycle arrest in human A549 cells assessed as accumulation at subG0 phase at 0.23 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 2 +/- 0.8%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID246826 | Effective dose against murine P388 leukemia cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID1353744 | Vascular disruptive activity in HMEC1 cells assessed as disruption of preformed tubular networks after 4 hrs by matrigel based assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID512069 | Antitumor activity against mouse 3LL cells transplanted in to BALB/c mouse assessed as tumor growth inhibition at 10 mg/kg, ip qd for 4 days | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
| AID1353635 | Antiproliferative activity against HEK293 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID344540 | Cytotoxicity against human DU145 cells after 48 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
| Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. |
| AID1278683 | Displacement of [3H]colchicine from bovine brain tubulin at 5 uM after 10 mins by scintillation counting analysis | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID247233 | Growth inhibition against human thyroid cell line( SW 1736) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID1353643 | Inhibition of calf brain tubulin polymerization in glycerol-assembly buffer assessed as critical concentration for tubulin assembly at 27.5 uM measured every 30 secs for 2 hrs in presence of GTP (Rvb = 8+/- 1 uM) | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID214036 | Inhibitory activity against tubulin polymerization | 1998 | Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
| Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships. |
| AID1600486 | Induction of mitotic block in human CCRF-CEM cells assessed as histone H3 Ser10 phosphorylation level at 5 times antiproliferative IC50 incubated for 48 hrs by PI staining based flow cytometric analysis (Rvb = 0.97%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1600484 | Induction of cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 5 times antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 12.12%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1570333 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 72 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1586359 | Antiproliferative activity against human MCF7 cells by MTT assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| AID1600465 | Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID247272 | Growth inhibition against human pancreas carcinoma cell line (BxPC-3) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID727502 | Cytotoxicity against human BGC832 cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
| Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. |
| AID1600476 | Therapeutic index, ratio of IC50 for human MCR5 cells to IC50 for human CCRF-CEM cells | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID344538 | Inhibition of calf brain tubulin polymerization | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
| Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. |
| AID1278673 | Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5
| Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. |
| AID1570335 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability measured after 24 hrs by cell titer blue assay | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID1353629 | Antiproliferative activity against human HT-29 cells after 2 days by MTT assay | 2018 | European journal of medicinal chemistry, Mar-10, Volume: 147 | Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents. |
| AID94325 | In vitro cytotoxic activity against human KB-VIN10 cell line overexpressing P-gp 170/MDR | 2004 | Journal of medicinal chemistry, May-20, Volume: 47, Issue:11
| Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. |
| AID1570326 | Prodrug activation assessed as Dengue virus serotype 2 NS2B-NS3 protease expressed in Escherichia coli BL21 lambda (DE3) cells-mediated compound hydrolysis in TRIS buffer at pH 9 at 500 uM incubated for 2 hrs by HPLC-UV analysis | 2019 | ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
| Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. |
| AID526491 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog. |
| AID344539 | Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
| Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. |
| AID247220 | Growth inhibition against human pharynx FADU cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
| AID1600478 | Induction of apoptosis in human CCRF-CEM cells assessed as accumulation at subG1 phase at 5 times antiproliferative IC50 incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 3.71%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19
| Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. |
| AID1586372 | Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 0.23 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 10 +/- 0.8%) | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |