virginiamycin M2: structure in first source
ID Source | ID |
---|---|
PubMed CID | 11756669 |
CHEMBL ID | 2105600 |
SCHEMBL ID | 20717840 |
SCHEMBL ID | 22550668 |
MeSH ID | M0374411 |
Synonym |
---|
volpristin |
volpristin [inn] |
(3r,4r,5e,10e,12e,14s,26ar)-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3h-21,18-nitrilo-1h,22h-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4h,17h)-tetrone |
18uan5144e , |
virginiamycin m2 |
(27r)-26,27-dihydrovirginiamycin m1 |
unii-18uan5144e |
ostreogrycin g |
CHEMBL2105600 |
3h-21,18-nitrilo-22h,24h-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4h,17h,25h)-tetrone, 8,9,14,15,26,26a-hexahydro-14-hydroxy-3-isopropyl-4,12-dimethyl- |
DTXSID10864978 |
SCHEMBL20717840 |
H8T , |
(3r,4r,5e,10e,12e,14s,26ar)-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1h,3h,22h-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4h,17h)-tetrone |
O8J , |
SCHEMBL22550668 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
30S ribosomal protein S6 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S7 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L15 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L10 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L11 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L19 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L1 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L20 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L27 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L28 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L29 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L31 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L32 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L33 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L34 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L35 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L36 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S10 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S11 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S12 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S13 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S16 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S18 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S19 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S20 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S2 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S3 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S4 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S5 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S8 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S9 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L13 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L14 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L16 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L23 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S15 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L17 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L21 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L30 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L6 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S14 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S17 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S1 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L18 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L2 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L3 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L24 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L4 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L22 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L5 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
30S ribosomal protein S21 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L25 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 (µMol) | 0.1000 | 0.0089 | 1.2035 | 5.0000 | AID1573014 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1573014 | Inhibition of bacterial ribosome assessed as reduction in poly(U) synthesis | 2018 | Journal of medicinal chemistry, 07-26, Volume: 61, Issue:14 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. |
AID1573015 | Antibacterial activity against quinolone sensitive Staphylococcus hominis IP8203 | 2018 | Journal of medicinal chemistry, 07-26, Volume: 61, Issue:14 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.87) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (20.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 4 (80.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |