Compounds > tu-514
Page last updated: 2024-12-08

tu-514

Cross-References

ID SourceID
PubMed CID449223
CHEMBL ID1236446
MeSH IDM0473390

Synonyms (11)

Synonym
CHEMBL1236446 ,
1,5-anhydro-2-c-(carboxymethyl-n-hydroxyamide)-2-deoxy-3-o-myristoyl-d-glucitol
tux ,
tu-514
1XXE
2GO4
DB01991
[(2r,3s,4r,5s)-3-hydroxy-5-[2-(hydroxyamino)-2-oxoethyl]-2-(hydroxymethyl)oxan-4-yl] tetradecanoate
bdbm50483375
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-o-tetradecanoyl-d-glucitol
Q27466758
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseAquifex aeolicusKi3.90003.90003.90003.9000AID977610
Chain A, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseAquifex aeolicusIC50 (µMol)7.00007.00007.00007.0000AID977608
UDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12Ki0.65000.00010.08800.6500AID568324; AID652927
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
lipid A biosynthetic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
phosphate-containing compound metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
lipid A biosynthetic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
organophosphate metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
carbohydrate derivative metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
iron ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
zinc ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
hydrolase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
metal ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
UDP-3-O-acyl-N-acetylglucosamine deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytoplasmUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB2005Biochemistry, Feb-01, Volume: 44, Issue:4
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2005Biochemistry, Feb-01, Volume: 44, Issue:4
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
AID568324Inhibition of Escherichia coli LpxC2011Bioorganic & medicinal chemistry letters, Feb-15, Volume: 21, Issue:4
Design and synthesis of potent Gram-negative specific LpxC inhibitors.
AID652927Inhibition of Escherichia coli LpxC2012Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2006Biochemistry, Jul-04, Volume: 45, Issue:26
Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
AID1811Experimentally measured binding affinity data derived from PDB2006Biochemistry, Jul-04, Volume: 45, Issue:26
Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index60.61 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.0210elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0610aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0610C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0610beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		7.0210amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		2.0210
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		2.0610macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
bb-78485
BB-78485: structure in first source		2.0710
l 161240
[no description available]		2.4720
chir 090
CHIR 090: structure in first source. CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide.		2.4720acetylenic compound;
benzamides;
hydroxamic acid;
L-threonine derivative;
morpholines		antimicrobial agent;
EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor;
lipopolysaccharide biosynthesis inhibitor
glycolipids
[no description available]		2.4220
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
chemdatabank.com