7-azaindole profile

7-Azaindole is a heterocyclic compound that is a structural isomer of indole. It is a colorless solid that is soluble in organic solvents. It is of interest to chemists due to its unusual electronic properties and its potential for use in various applications, including pharmaceuticals, organic electronics, and materials science. 7-azaindole has been studied for its biological activity, particularly as a potential therapeutic agent for a variety of conditions such as cancer and inflammatory diseases. Its synthesis involves the reaction of 2-amino-3-nitropyridine with sodium dithionite. It has also been investigated for its use in the development of new organic materials, such as organic light-emitting diodes (OLEDs) and sensors, due to its ability to form stable complexes with metals.'

ID Source	ID
PubMed CID	9222
CHEMBL ID	389685
CHEBI ID	194830
SCHEMBL ID	17837
MeSH ID	M0450566

Synonym
AC-1215
AKOS000446848
einecs 205-981-0
1h-pyrrolo(2,3-b)pyridine
1,7-dideazapurine
nsc 67063
7h-pyrrolo(2,3-b)pyridine
EN300-25796
NCIOPEN2_000707
gvh ,
7h-pyrrolo[2,3-b]pyridine
1,7-diazaindene
wln: t56 bm inj
nsc-67063
7-azaindole ,
nsc67063
7-aza-1-pyrindine
nsc-77951
nsc77951
inchi=1/c7h6n2/c1-2-6-3-5-9-7(6)8-4-1/h1-5h,(h,8,9
1h-pyrrolo[2,3-b]pyridine
271-63-6
7-azaindole, 98%
bdbm16223
A-9500
STK503791
CHEMBL389685
P1117
CHEBI:194830
NCGC00188278-01
qx4465nr9t ,
pyrrolo(2,3-b)pyridine
unii-qx4465nr9t
89267-19-6
FT-0604377
PS-4533
AM20070247
pyrrolo[2,3-b]pyridine
PB32078
SC1771
CS-B0516
SCHEMBL17837
SY001940
mfcd00005606
7-aza-indole
pyrrolo[2,3-b]-pyridine
7-azaindol
1h-pyrrolo(2,3-b)-pyridine
1-h-pyrrolo[2,3-b]pyridine
pyrrolo[b]pyridine
1h-pyrrole(2,3-b)pyridine
STR01850
DTXSID3075046
F0001-0881
7-aza indole
BCP26852
Q27287542
25247-73-8
HY-50542
Z271099378

Class	Description
pyrrolopyridine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (7)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	100.0000	0.0501	27.0736	89.1251	AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	IC50 (µMol)	648.9785	0.0009	0.9781	9.8200	AID613176
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	IC50 (µMol)	391.0000	0.0007	0.4116	9.1000	AID1781832
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	IC50 (µMol)	399.0535	0.0002	0.7387	10.0000	AID613174
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0005	0.5013	7.6000	AID1797482; AID286919; AID327087
7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)	IC50 (µMol)	132.0000	0.0520	1.2093	5.6000	AID1596624
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50 (µMol)	648.9785	0.0020	1.0173	5.4200	AID613175
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)	Kd	96.0000	0.0390	0.0390	0.0390	AID1596626
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (230)

Process	via Protein(s)	Taxonomy
positive regulation of NF-kappaB transcription factor activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
MyD88-dependent toll-like receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein phosphorylation	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
inflammatory response	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
canonical NF-kappaB signal transduction	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
response to virus	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
regulation of tumor necrosis factor-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
peptidyl-serine phosphorylation	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
cortical actin cytoskeleton organization	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
toll-like receptor 3 signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
negative regulation of myosin-light-chain-phosphatase activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
TRIF-dependent toll-like receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
regulation of phosphorylation	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
innate immune response	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
positive regulation of DNA-templated transcription	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
T cell receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
stress-activated MAPK cascade	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein maturation	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
cellular response to tumor necrosis factor	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein localization to plasma membrane	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
regulation of establishment of endothelial barrier	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
negative regulation of bicellular tight junction assembly	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
regulation of toll-like receptor signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
neuron migration	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of cytokine-mediated signaling pathway	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
blood vessel remodeling	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
phagocytosis	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
inflammatory response	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
signal transduction	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
spermatogenesis	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of macrophage cytokine production	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
forebrain cell migration	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
animal organ regeneration	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of type II interferon production	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of natural killer cell differentiation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
secretion by cell	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
erythrocyte homeostasis	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cellular response to interferon-alpha	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
ovulation cycle	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of neuron apoptotic process	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
symbiont entry into host cell	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cell maturation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of pinocytosis	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
response to axon injury	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of lymphocyte activation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
neuron apoptotic process	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
establishment of localization in cell	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
vagina development	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cellular response to hydrogen peroxide	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cellular response to lipopolysaccharide	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
dendritic cell differentiation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
neutrophil clearance	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of viral life cycle	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of dendritic cell apoptotic process	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
platelet activation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
natural killer cell differentiation	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cell migration	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
positive regulation of kinase activity	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
nervous system development	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
multicellular organism development	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
negative regulation of apoptotic process	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
activation-induced cell death of T cells	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
osteoblast differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
maternal placenta development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endothelial cell proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glucose metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of translation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein import into nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nitric oxide biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
inflammatory response	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to oxidative stress	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
G protein-coupled receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
canonical NF-kappaB signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell population proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
insulin receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
apoptotic mitochondrial changes	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to heat	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of autophagy	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endothelial cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of long-chain fatty acid import across plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
fibroblast migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fibroblast migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of sodium ion transport	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of endopeptidase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of neuron projection development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of macroautophagy	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein ubiquitination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-serine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-threonine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
virus-mediated perturbation of host defense response	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytokine-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mammalian oogenesis stage	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell growth	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
T cell costimulation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein ubiquitination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of myelination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
TOR signaling	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of fatty acid beta-oxidation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endodeoxyribonuclease activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to food	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peripheral nervous system myelin maintenance	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to insulin stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to fluid shear stress	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to reactive oxygen species	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
interleukin-18-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to decreased oxygen levels	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glucose homeostasis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
anoikis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of mRNA stability	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fat cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of Notch signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of proteolysis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of DNA-templated transcription	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose import	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of organ growth	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein autophosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of lipid biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
behavioral response to pain	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of nitric-oxide synthase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
striated muscle cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
excitatory postsynaptic potential	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to growth hormone	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mammary gland epithelial cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
labyrinthine layer blood vessel development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to UV-A	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to growth factor	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to cadmium ion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to tumor necrosis factor	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to prostaglandin E stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
establishment of protein localization to mitochondrion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
maintenance of protein location in mitochondrion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to granulocyte macrophage colony-stimulating factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
execution phase of apoptosis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of postsynapse organization	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of tRNA methylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to oxidised low-density lipoprotein particle stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein localization to lysosome	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cGAS/STING signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to peptide	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cilium assembly	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of leukocyte cell-cell adhesion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of I-kappaB phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of TORC1 signaling	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to endoplasmic reticulum	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to nerve growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to insulin-like growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to cell surface	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of type B pancreatic cell development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of lymphocyte migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glycogen biosynthetic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
glucose metabolic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of translation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
signal transduction	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
insulin receptor signaling pathway	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of long-chain fatty acid import across plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose metabolic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell migration	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell migration	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fatty acid beta-oxidation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
peripheral nervous system myelin maintenance	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cellular response to insulin stimulus	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein modification process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
fat cell differentiation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glycogen biosynthetic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose import	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell cycle	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
mammary gland epithelial cell differentiation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cellular response to high light intensity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
organic substance transport	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein localization to plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein targeting to membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
retinal rod cell apoptotic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell motility	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-serine phosphorylation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
purine nucleoside catabolic process	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
DNA repair	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
response to oxidative stress	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
male gonad development	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
DNA protection	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
response to cadmium ion	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
JUN phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to UV	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to lipopolysaccharide	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to oxidative stress	Mitogen-activated protein kinase 8	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase 8	Homo sapiens (human)
JUN phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of gene expression	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of macroautophagy	Mitogen-activated protein kinase 8	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
peptidyl-threonine phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of cyclase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of cell killing	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of protein binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of protein localization	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to oxidative stress	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 8	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of circadian rhythm	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
rhythmic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of protein metabolic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 8	Homo sapiens (human)
energy homeostasis	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to mechanical stimulus	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of establishment of protein localization to mitochondrion	Mitogen-activated protein kinase 8	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (46)

Process	via Protein(s)	Taxonomy
protein kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein serine/threonine kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
ATP binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
IkappaB kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein kinase binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
identical protein binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein homodimerization activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein heterodimerization activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
scaffold protein binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
protein serine kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
transferrin receptor binding	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
virus receptor activity	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
phosphatidylserine binding	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
protein binding	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
myosin heavy chain binding	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
protein kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
calmodulin binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol-3,4,5-trisphosphate binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
enzyme binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein kinase binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nitric-oxide synthase regulator activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase inhibitor activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
identical protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein homodimerization activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol-3,4-bisphosphate binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
14-3-3 protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
potassium channel activator activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
metal ion binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
molecular function activator activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
protein binding	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
dATP diphosphatase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
snoRNA binding	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
metal ion binding	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
ATP diphosphatase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
2-hydroxy-ATP hydrolase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
2-hydroxy-dATP hydrolase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
N6-methyl-(d)ATP hydrolase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
O6-methyl-dGTP hydrolase activity	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
JUN kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
enzyme binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein phosphatase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
histone deacetylase regulator activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
histone deacetylase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein serine/threonine kinase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Process	via Protein(s)	Taxonomy
cytoplasm	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
nucleus	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
cytosol	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
IkappaB kinase complex	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
cytoplasmic side of plasma membrane	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
membrane raft	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
CD40 receptor complex	Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)
extracellular space	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cell surface	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
actin cytoskeleton	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
receptor complex	Tyrosine-protein kinase receptor UFO	Homo sapiens (human)
cytoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mitochondrial intermembrane space	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
spindle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytosol	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell-cell junction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell cortex	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
microtubule cytoskeleton	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
lamellipodium	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
vesicle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
ciliary basal body	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
postsynapse	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glutamatergic synapse	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein-containing complex	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleus	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
nucleoplasm	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
early endosome	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cytosol	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cell cortex	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
ruffle membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
intracellular membrane-bounded organelle	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
acrosomal vesicle	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
extracellular space	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
nucleus	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
cytoplasm	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
mitochondrion	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
mitochondrial matrix	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
cytosol	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
nuclear membrane	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
cytoplasm	7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 8	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 8	Homo sapiens (human)
axon	Mitogen-activated protein kinase 8	Homo sapiens (human)
synapse	Mitogen-activated protein kinase 8	Homo sapiens (human)
basal dendrite	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 8	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (48)

Assay ID	Title	Year	Journal	Article
AID613176	Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613148	Inhibition of AKT2 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1891831	Lipid-water distribution ratio of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
AID613155	Inhibition of ErbB2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID286921	Inhibition of PC3M cells by SRB assay after 96 hrs	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
AID613174	Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613160	Inhibition of ITK expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613170	Inhibition of RIP2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1781832	Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrs	2021	Bioorganic & medicinal chemistry, 11-01, Volume: 49	Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
AID613175	Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613152	Inhibition of B-Raf expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 400 uM by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613169	Inhibition of PIM1 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1254099	Binding affinity to rabbit muscle glycogen phosphorylase by STD NMR spectrometric analysis	2015	Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21	Ligand-Orientation Based Fragment Selection in STD NMR Screening.
AID613157	Inhibition of FAK expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613167	Inhibition of PI3Kalpha expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID327087	Inhibition of PKBbeta recombinant by radiometric filter binding assay	2008	Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7	Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
AID613159	Inhibition of IGF1R expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613154	Inhibition of FES expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 400 uM by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613143	Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613163	Inhibition of p38alpha expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613156	Inhibition of ErbB4 expressed in Escherichia coli or baculovirus-infected insect cells at 400 to 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613161	Inhibition of JAK3 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID70363	The binding affinity towards N-labeled Erythromycin-resistant ErmAM methylase evaluated by NMR	1999	Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19	Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
AID613151	Inhibition of AurB expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613173	Inhibition of SYK expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID73213	Residual porcine GSK-3-alpha/beta kinase activity with L240C/N297Q mutant cytochrome P450 2A6 extract	2004	Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12	Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
AID613172	Inhibition of SGK1 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613145	Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1254102	Binding affinity to ERK1 (unknown origin) expressed in Escherichia coli by STD NMR spectrometric analysis	2015	Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21	Ligand-Orientation Based Fragment Selection in STD NMR Screening.
AID1596624	Inhibition of recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate incubated for 15 mins by malachite green dye based pyrophosphatase coupled colorimetric assay	2019	European journal of medicinal chemistry, Aug-01, Volume: 175	Ligand retargeting by binding site analogy.
AID613165	Inhibition of PAK2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613153	Inhibition of EGFR expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613158	Inhibition of GSK3-beta expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 667 uM by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613162	Inhibition of MK2 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613168	Inhibition of PI3Kdelta expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613150	Inhibition of AurA expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID613147	Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1891830	Basic dissociation constant, pKa of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
AID613166	Inhibition of PDK1 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID54188	Residual Cyclin-dependent kinase 5-p35nck5a activity with L240C/N297Q mutant cytochrome P450 2A6 extract	2004	Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12	Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
AID613171	Inhibition of ROCK1 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID286920	Inhibition of PKA by radiometric filter binding assay	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
AID1596626	Binding affinity to recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by isothermal titration calorimetry	2019	European journal of medicinal chemistry, Aug-01, Volume: 175	Ligand retargeting by binding site analogy.
AID613149	Inhibition of ASK1 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by IMAP assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID1596625	Binding affinity to recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry	2019	European journal of medicinal chemistry, Aug-01, Volume: 175	Ligand retargeting by binding site analogy.
AID613144	Inhibition of PI3Kgamma expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Selectivity of kinase inhibitor fragments.
AID286919	Inhibition of PKBbeta by radiometric filter binding assay	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
AID1797482	PKB In Vitro Enzyme Assay from Article 10.1021/jm0700924: \\Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design.\\	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (11.11)	18.2507
2000's	3 (33.33)	29.6817
2010's	3 (33.33)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (11.11%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.06	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
indole [no description available]	3.88	3	indole; polycyclic heteroarene	Escherichia coli metabolite
e 4031 E 4031: class III anti-arrhythmia agent; structure given in UD	2.21	1	sulfonamide
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source	2.04	1	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector
2-phenylphenol 2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.	2.11	1	hydroxybiphenyls	antifungal agrochemical; environmental food contaminant
1,3-diphenylurea 1,3-diphenylurea : A member of the class of phenylureas that is urea in which one of the hydrogens of each amino group is replaced by a phenyl group. It is present in coconut milk (Cocos nucifera).	2.06	1	phenylureas	cytokinin; plant metabolite
2-aminobenzothiazole [no description available]	2	1	benzothiazoles
6-azaindole [no description available]	3.51	1
5-azaindole [no description available]	3.51	1
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.06	1	indazole
4-azaindole [no description available]	3.51	1
2-aminopurine 2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.	2.11	1	2-aminopurines; nucleobase analogue	antimetabolite
4-methylcatechol [no description available]	2.11	1	methylcatechol	antioxidant; carcinogenic agent; hapten; human metabolite; plant metabolite
indirubin [no description available]	2.02	1
indigo [no description available]	2.02	1	hydroxyindoles
diphenylamine Diphenylamine: In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.. diphenylamine : An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union.	2.06	1	aromatic amine; bridged diphenyl fungicide; secondary amino compound	antifungal agrochemical; antioxidant; carotogenesis inhibitor; EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor; ferroptosis inhibitor; radical scavenger
5-methylindole [no description available]	2.02	1
1H-indazol-3-amine 1H-indazol-3-amine: structure in first source	2.06	1	indazoles
2-aminobenzimidazole 2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd. 2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group.	2.21	1	benzimidazoles	marine xenobiotic metabolite
5-methoxyindole 5-methoxyindole: structure in first source	2.02	1	indoles
1h-imidazo(4,5-b)pyridine 1H-imidazo(4,5-b)pyridine: structure given in first source. 4-azabenzimidazole : The [4,5-b]-fused isomer of imidazopyridine.	2.21	1	imidazopyridine
2,2'-bisphenol f 2,2'-bisphenol F: contact allergen; structure given in first source	2.11	1	diarylmethane
5-aminoindole 5-aminoindole: structure in first source. 1H-indol-5-amine : An indolamine carrying an amino group at position 5.	2.02	1	indolamine
6-Fluoro-1,3-benzothiazol-2-amine [no description available]	2.31	1	benzothiazoles
s-adenosylhomocysteine S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.	2	1	adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide	cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite
h 89 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide: structure given in first source. N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.. (E)-N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide : A N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide in which the double bond adopts a trans-configuration.	2.44	2	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
bms-488043 BMS-488043: anti-HIV agent	3.51	1
2,4-Di(3-pyridyl)-1,3-thiazole [no description available]	2.31	1	thiazoles
Methyl indole-5-carboxylate [no description available]	2.02	1	indolyl carboxylic acid
bms-585248 [no description available]	3.51	1
cct 128930 [no description available]	2.04	1
gsk 650394 [no description available]	2.06	1	phenylpyridine

Condition	Indicated	Relationship Strength	Studies	Trials
Grippe [description not available]	0	3.33	1	0
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	0	3.33	1	0

7-azaindole

Cross-References

Synonyms (60)

Drug Classes (1)

Protein Targets (7)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (230)

Molecular Functions (46)

Ceullar Components (36)

Bioassays (48)

Research

Studies (9)

Market Indicators

Research Demand Index: 49.98

Study Types

7-azaindole

Cross-References

Synonyms (60)

Drug Classes (1)

Protein Targets (7)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (230)

Molecular Functions (46)

Ceullar Components (36)

Bioassays (48)

Research

Studies (9)

Market Indicators

Research Demand Index: 49.98

Study Types

Related Drugs (32)

Related Conditions (2)