| Assay ID | Title | Year | Journal | Article |
|---|
| AID707482 | Binding affinity to CLK1 | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871895 | Inhibition of human recombinant CK2 at 10 uM using RRRDDDSDDD peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707477 | Binding affinity to CLK2 | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871875 | Inhibition of GST-fused mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID1871918 | Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells at 20 uM treated for 24 hrs by MTS assay | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707501 | Inhibition of pig GSK3alpha/beta isolated from brain using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871883 | Inhibition of GST-fused human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID1871901 | Antagonist activity at CP-55940-activated CB1 receptor (unknown origin) at 10 uM by beta-arrestin assay relative to control | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID606277 | Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID1871900 | Inhibition of DYRK1A in human SH-SY5Y overexpressing Tau4R cells assessed as phosphorylated Tau Thr212 residue level at 10 uM incubated for 6 hrs by western blot analysis relative to control | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707257 | Inhibition of Plasmodium falciparum recombinant GSK3 expressed in Escherichia coli using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP at 10 uM after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871889 | Inhibition of GST-fused human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID1871916 | Neurotoxicity against mouse HT-22 cells assessed as cell survival at 20 uM treated for 24 hrs by MTS assay | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707686 | Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID606281 | Inhibition of pig brain CK1 delta/epsilon using RRKHAAIGpSAYSITA as substrate | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707683 | Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707688 | Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871879 | Inhibition of GST-fused mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707694 | Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707508 | Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID606275 | Inhibition of rat recombinant GST-tagged DYRK1A using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707692 | Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871881 | Inhibition of mouse recombinant GST-fused CLK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID470788 | Inhibition of human CDK5/p25 | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2
| Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. |
| AID707256 | Inhibition of Leishmania major recombinant CK1 expressed in Escherichia coli using RRKHAAIGpSAYSITA as substrate and [gamma33P]ATP at 10 uM after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707684 | Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707693 | Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707503 | Inhibition of human recombinant GSK3alpha expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707500 | Inhibition of human recombinant PIM1 expressed in Escherichia coli using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707480 | Binding affinity to CLK3 | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID606280 | Inhibition of pig brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707476 | Binding affinity to DYRK1B | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID606278 | Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID1871887 | Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID606282 | Inhibition of human recombinant Pim1 | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707689 | Inhibition of human recombinant CK2 using RRREDEESDDEE as substrate and [gamma33P]ATP at 10 uM after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707504 | Inhibition of rat recombinant ERK2 using Ets1 as substrate and [gamma33P]ATP as substrate after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707507 | Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707702 | Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707696 | Inhibition of starfish CDK1/cyclin B using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871873 | Inhibition of porcine brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQpSEDEEE as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID337561 | Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane | 1993 | Journal of natural products, Jan, Volume: 56, Issue:1
| New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis. |
| AID707691 | Inhibition of pig CD1delta/epsilon isolated from brain using RRKHAAIGpSAYSITA as substrate and [gamma33P]ATP after 30 mins by scintillation couting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707483 | Binding affinity to DYRK2 | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871892 | Inhibition of human recombinant Pim1 expressed in Escherichia coli using histone H1 as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID470787 | Inhibition of human CK1-alpha/CK2beta | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2
| Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. |
| AID707502 | Inhibition of human recombinant GSK3beta expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID606279 | Inhibition of human recombinant CDK5/p25 | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707505 | Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871878 | Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707509 | Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707485 | Binding affinity to CLK4 | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871898 | Induction of PI3K/mTor-dependent autophagy in human U2OS cells assessed as number of LC3 foci per cell at 10 uM measured after 4 hrs | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID470789 | Inhibition of human GSK3alpha/ GSK3-beta | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2
| Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. |
| AID707695 | Inhibition of CDK2/cyclin A using [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871885 | Inhibition of GST-fused human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID707687 | Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID1871899 | Modulation of CLK1 pre-mRNA splicing in mouse HT-22 cells assessed as inclusion of CLK1 exon 4 by measuring change in threshold cycle at 10 uM measured after 4 hrs by real time PCR analysis | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID1871902 | Antagonist activity at CP-55940-activated CB1 receptor (unknown origin) by beta-arrestin assay | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. |
| AID606276 | Inhibition of human recombinant GST-tagged DYRK2 using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. |
| AID707484 | Binding affinity to DYRK1A | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707685 | Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| AID707506 | Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |