Proteins > UDP-3-O-acyl-N-acetylglucosamine deacetylase
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UDP-3-O-acyl-N-acetylglucosamine deacetylase
A UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A725]
Synonyms
UDP-3-O-acyl-GlcNAc deacetylase;
EC 3.5.1.108;
Protein EnvA;
UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tu-514 | Escherichia coli K-12 | Ki | 0.6500 | 2 | 2 |
| bb-78485 | Escherichia coli K-12 | Ki | 0.0067 | 3 | 3 |
| l 161240 | Escherichia coli K-12 | IC50 | 0.0300 | 1 | 1 |
| l 161240 | Escherichia coli K-12 | Ki | 0.0301 | 5 | 5 |
| chir 090 | Escherichia coli K-12 | IC50 | 0.0305 | 4 | 4 |
| chir 090 | Escherichia coli K-12 | Ki | 0.0037 | 7 | 7 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chir 090 | Escherichia coli K-12 | Km | 7.5000 | 2 | 2 |
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012
Design and synthesis of potent Gram-negative specific LpxC inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 21, Issue:4, 2011
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012
Design and synthesis of potent Gram-negative specific LpxC inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 21, Issue:4, 2011
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents.ACS medicinal chemistry letters, , Jun-09, Volume: 7, Issue:6, 2016
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 22, Issue:3, 2014
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012
Design and synthesis of potent Gram-negative specific LpxC inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 21, Issue:4, 2011
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007