azd2932 profile

AZD2932: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	11517980
CHEMBL ID	1940274
SCHEMBL ID	1099958
MeSH ID	M0575601

Synonym
2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-n-(1-propan-2-ylpyrazol-4-yl)acetamide
bdbm50362058
CHEMBL1940274 ,
azd-2932
S7003
HY-18179
azd2932
CS-3356
SCHEMBL1099958
883986-34-3
AC-33005
AKOS026750228
EX-A998
benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-n-[1-(1-methylethyl)-1h-pyrazol-4-yl]-
2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-n-(1-isopropyl-1h-pyrazol-4-yl)acetamide
mfcd25977021
NCGC00390637-02
benzeneacetamide, 4-((6,7-dimethoxy-4-quinazolinyl)oxy)-n-(1-(1-methylethyl)-1h-pyrazol-4-yl)-
4-((6,7-dimethoxy-4-quinazolinyl)oxy)-n-(1-(1-methylethyl)-1h-pyrazol-4-yl)benzeneacetamide
SJ9PP5S9IM ,
BCP07984
unii-sj9pp5s9im
CCG-269204
NCGC00481555-01
azd 2932
MS-28100

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Excerpt	Relevance	Reference
" Here we describe the identification of potent pan-KIT mutant kinase inhibitors that can be dosed without being limited by the tolerability issues seen with multitargeted agents."	( Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. Anjum, R; Barry, E; Bhavsar, D; Boyd, S; Brown, C; Campbell, A; Goldberg, K; Grondine, M; Guichard, S; Hardy, CJ; Hunt, T; Jones, RDO; Kettle, JG; Li, X; Moleva, O; Ogg, D; Overman, RC; Packer, MJ; Pearson, S; Schimpl, M; Shao, W; Smith, A; Smith, JM; Stead, D; Stokes, S; Tucker, M; Ye, Y, 2018)	0.48

Protein Targets (15)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	10.6840	0.0123	7.9835	43.2770	AID1645841
G	Vesicular stomatitis virus	Potency	13.4504	0.0123	8.9648	39.8107	AID1645842
Interferon beta	Homo sapiens (human)	Potency	13.4504	0.0033	9.1582	39.8107	AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	13.4504	0.0123	8.9648	39.8107	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	13.4504	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	13.4504	0.0123	8.9648	39.8107	AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50 (µMol)	0.1000	0.0006	0.5676	5.5450	AID639907; AID660687
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50 (µMol)	0.0040	0.0006	0.8007	8.5000	AID639905; AID660685
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	GI50	0.0287	0.0010	0.7801	9.9300	AID1386988; AID1386989; AID1386990
Cytochrome P450 2C9	Homo sapiens (human)	IC50 (µMol)	8.0000	0.0000	2.8005	10.0000	AID639908
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50 (µMol)	0.0080	0.0001	0.2264	4.9000	AID639906
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	GI50	0.0930	0.0030	0.8305	4.6000	AID1386991
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50 (µMol)	0.0080	0.0000	0.4830	8.8000	AID660686
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50 (µMol)	0.0070	0.0001	0.3275	9.5480	AID1557185; AID639909; AID657731
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50 (µMol)	137.0000	0.0009	1.9014	10.0000	AID641365
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	INH	0.0020	0.0020	0.0020	0.0020	AID641367
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (296)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
positive regulation of T cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
adaptive immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of T cell anergy	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
defense response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
detection of bacterium	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-12 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-6 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protection from natural killer cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
innate immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of dendritic cell differentiation	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
positive regulation of macrophage chemotaxis	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of macrophage proliferation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
response to ischemia	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
inflammatory response	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
signal transduction	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
axon guidance	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cell population proliferation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
negative regulation of cell population proliferation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
regulation of cell shape	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cytokine-mediated signaling pathway	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
olfactory bulb development	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
forebrain neuron differentiation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
hemopoiesis	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
monocyte differentiation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
macrophage differentiation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
osteoclast differentiation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
ruffle organization	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of chemokine production	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
regulation of actin cytoskeleton organization	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cellular response to macrophage colony-stimulating factor stimulus	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
macrophage colony-stimulating factor signaling pathway	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
negative regulation of apoptotic process	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation by host of viral process	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
innate immune response	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
regulation of bone resorption	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cell-cell junction maintenance	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
protein autophosphorylation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
mammary gland duct morphogenesis	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of protein tyrosine kinase activity	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
microglial cell proliferation	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cellular response to cytokine stimulus	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
regulation of macrophage migration	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of cell motility	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of cell migration	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
regulation of MAPK cascade	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
positive regulation of kinase activity	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
multicellular organism development	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell population proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phospholipase C activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
regulation of actin cytoskeleton organization	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in vasculogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
aorta morphogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of MAP kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of mitotic nuclear division	Platelet-derived growth factor receptor beta	Homo sapiens (human)
phosphatidylinositol metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein autophosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cardiac myofibril assembly	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in coronary angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
retina vasculature development in camera-type eye	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Platelet-derived growth factor receptor beta	Homo sapiens (human)
smooth muscle cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular mesangial cell proliferation involved in metanephros development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular capillary formation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium ion import	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
multicellular organism development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
ovarian follicle development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
myeloid progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
lymphoid progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
immature B cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell chemotaxis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of dendritic cell cytokine production	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
glycosphingolipid metabolic process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
inflammatory response	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
spermatogenesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
spermatid development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
germ cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of cell shape	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
visual learning	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
male gonad development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of phospholipase C activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytokine-mediated signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell population maintenance	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
lamellipodium assembly	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
actin cytoskeleton organization	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hemopoiesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
T cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
erythrocyte differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of pseudopodium assembly	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of mast cell cytokine production	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
somatic stem cell population maintenance	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
embryonic hemopoiesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
ectopic germ cell programmed cell death	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
intracellular signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hematopoietic stem cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
megakaryocyte development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
Fc receptor signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
Kit signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
erythropoietin-mediated signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of cell population proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of programmed cell death	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell degranulation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of MAPK cascade	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
pigmentation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
tongue development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of Notch signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
response to cadmium ion	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein autophosphorylation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of long-term neuronal synaptic plasticity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
digestive tract development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
epithelial cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of sound	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of developmental process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cell chemotaxis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of mast cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte adhesion	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of pyloric antrum smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of bile acid metabolic process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of colon smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of small intestine smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of reproductive process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of MAP kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
multicellular organism development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
B cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
epoxygenase P450 pathway	Cytochrome P450 2C9	Homo sapiens (human)
urea metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
monocarboxylic acid metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2C9	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 2C9	Homo sapiens (human)
amide metabolic process	Cytochrome P450 2C9	Homo sapiens (human)
icosanoid biosynthetic process	Cytochrome P450 2C9	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 2C9	Homo sapiens (human)
omega-hydroxylase P450 pathway	Cytochrome P450 2C9	Homo sapiens (human)
cellular response to reactive oxygen species	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
luteinization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
in utero embryonic development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell activation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
estrogen metabolic process	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell population proliferation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
negative regulation of platelet activation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of phospholipase C activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
signal transduction involved in regulation of gene expression	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
extracellular matrix organization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
lung development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
adrenal gland development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell migration	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
male genitalia development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
regulation of actin cytoskeleton organization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
Leydig cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor-alpha signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
wound healing	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein autophosphorylation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of fibroblast proliferation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic digestive tract morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic skeletal system morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
white fat cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of chemotaxis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cardiac myofibril assembly	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
roof of mouth development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
face morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell chemotaxis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
retina vasculature development in camera-type eye	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet aggregation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cellular response to amino acid stimulus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
metanephric glomerular capillary formation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
regulation of mesenchymal stem cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
multicellular organism development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of protein phosphorylation	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
vasculature development	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
lymph vessel development	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
lymphangiogenesis	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
sprouting angiogenesis	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
respiratory system process	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of cell population proliferation	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of endothelial cell migration	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
negative regulation of apoptotic process	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of MAPK cascade	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of JNK cascade	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
protein autophosphorylation	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
lung alveolus development	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
blood vessel morphogenesis	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
regulation of blood vessel remodeling	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of protein kinase C signaling	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of cell migration	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
positive regulation of kinase activity	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
multicellular organism development	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
regulation of MAPK cascade	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
angiogenesis	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
branching involved in blood vessel morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of macroautophagy	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial depolarization	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial fission	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ovarian follicle development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of protein phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lymph vessel development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell maturation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endocardium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell population proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of cell shape	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of gene expression	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of BMP signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
embryonic hemopoiesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor-2 signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
surfactant homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of neuron apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell fate commitment	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lung alveolus development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
post-embryonic camera-type eye morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of positive chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of focal adhesion assembly	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
calcium ion homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
blood vessel endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular wound healing	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
semaphorin-plexin signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of hematopoietic progenitor cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of bone development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to hydrogen sulfide	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
multicellular organism development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
hemopoiesis	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
leukocyte homeostasis	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
myeloid progenitor cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
pro-B cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of cell population proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
response to organonitrogen compound	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cytokine-mediated signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
B cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
animal organ regeneration	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
common myeloid progenitor cell proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
regulation of apoptotic process	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of MAP kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of MAPK cascade	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
lymphocyte proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein autophosphorylation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cellular response to cytokine stimulus	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cellular response to glucocorticoid stimulus	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
dendritic cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
multicellular organism development	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of heart rate by hormone	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of membrane potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion homeostasis	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cardiac muscle contraction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cellular response to xenobiotic stimulus	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
ventricular cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane depolarization during action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion export across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during ventricular cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
negative regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
positive regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
negative regulation of potassium ion export across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion import across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inositol phosphate metabolic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (72)

Process	via Protein(s)	Taxonomy
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
signaling receptor binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
peptide antigen binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein-folding chaperone binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein tyrosine kinase activity	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
macrophage colony-stimulating factor receptor activity	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
protein binding	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
ATP binding	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
protein phosphatase binding	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cytokine binding	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
protein homodimerization activity	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
growth factor binding	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
protein kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein tyrosine kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet activating factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor beta-receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
signaling receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
ATP binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
enzyme binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein kinase binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
vascular endothelial growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protease binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein tyrosine kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell factor receptor activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
ATP binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytokine binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
SH2 domain binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein homodimerization activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
metal ion binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
growth factor binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
iron ion binding	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid 14,15-epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
arachidonic acid 11,12-epoxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2C9	Homo sapiens (human)
(S)-limonene 6-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
(S)-limonene 7-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 2C9	Homo sapiens (human)
(R)-limonene 6-monooxygenase activity	Cytochrome P450 2C9	Homo sapiens (human)
aromatase activity	Cytochrome P450 2C9	Homo sapiens (human)
heme binding	Cytochrome P450 2C9	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2C9	Homo sapiens (human)
protein kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor alpha-receptor activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
ATP binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
vascular endothelial growth factor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein homodimerization activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein-containing complex binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
protein binding	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
ATP binding	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
growth factor binding	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
protein phosphatase binding	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
protein homodimerization activity	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
integrin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ATP binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
coreceptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
identical protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cadherin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Hsp90 protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein tyrosine kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cytokine receptor activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
ATP binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
nuclear glucocorticoid receptor binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein-containing complex binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
growth factor binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
transcription cis-regulatory region binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inward rectifier potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
delayed rectifier potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
ubiquitin protein ligase binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
identical protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein homodimerization activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
C3HC4-type RING finger domain binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
scaffold protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol heptakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
protein binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
ATP binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 1-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 3-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (47)

Process	via Protein(s)	Taxonomy
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
Golgi membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
endoplasmic reticulum	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
Golgi apparatus	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
ER to Golgi transport vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
secretory granule membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
phagocytic vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
early endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
recycling endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular exosome	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
lumenal side of endoplasmic reticulum membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
MHC class I protein complex	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular space	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
external side of plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
nucleoplasm	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
plasma membrane	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
cell surface	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
intracellular membrane-bounded organelle	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
CSF1-CSF1R complex	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
receptor complex	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
plasma membrane	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)
nucleus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasm	Platelet-derived growth factor receptor beta	Homo sapiens (human)
Golgi apparatus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
focal adhesion	Platelet-derived growth factor receptor beta	Homo sapiens (human)
membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
apical plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasmic vesicle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
lysosomal lumen	Platelet-derived growth factor receptor beta	Homo sapiens (human)
intracellular membrane-bounded organelle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
receptor complex	Platelet-derived growth factor receptor beta	Homo sapiens (human)
fibrillar center	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
acrosomal vesicle	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
extracellular space	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cell-cell junction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
external side of plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytoplasmic side of plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
receptor complex	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2C9	Homo sapiens (human)
plasma membrane	Cytochrome P450 2C9	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C9	Homo sapiens (human)
cytoplasm	Cytochrome P450 2C9	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2C9	Homo sapiens (human)
nucleus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
nucleoplasm	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cytoplasm	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
endoplasmic reticulum membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
Golgi apparatus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
microvillus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cilium	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
external side of plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell junction	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein-containing complex	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
receptor complex	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
extracellular region	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
nucleoplasm	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
cytosol	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
receptor complex	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 3	Homo sapiens (human)
extracellular region	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
nucleus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
early endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endoplasmic reticulum	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Golgi apparatus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
external side of plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
membrane raft	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
anchoring junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
sorting endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
receptor complex	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endoplasmic reticulum	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
endoplasmic reticulum lumen	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
plasma membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
endosome membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
receptor complex	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
plasma membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cell surface	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
perinuclear region of cytoplasm	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel complex	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inward rectifier potassium channel complex	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
fibrillar center	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytosol	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleus	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (46)

Assay ID	Title	Year	Journal	Article
AID641368	Inhibition of PDGFRalpha phosphorylation in rat C6 cells xenografted in po dosed nude mouse after 6 hrs	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID1386990	Inhibition of Kit exon 11 deletion (557 to 558 residues) and D816H mutant and T670I mutant (unknown origin) transfected in mouse BA/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	2018	Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
AID660685	Inhibition of PDGFRbeta	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
AID1386988	Inhibition of Kit exon 11 deletion (557 to 558 residues) and V654A mutant (unknown origin) transfected in mouse BA/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	2018	Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
AID639911	Hepatic blood flow in rat at 0.5 to 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641369	Inhibition of PDGFRalpha phosphorylation in rat C6 cells xenografted in nude mouse at 3 mg/kg, po	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639920	Terminal half life in dog at 2 mg/kg, iv	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641373	Antitumor activity against human LoVo cells xenografted in nude mouse assessed as tumor growth inhibition at 50 mg/kg bid for 22 days	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639919	Terminal half life in rat at 2 mg/kg, iv	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639903	Inhibition of c-Kit	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639913	Hepatic blood flow in dog at 0.5 to 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID1386989	Inhibition of Kit exon 11 deletion (557 to 558 residues) and D816H mutant (unknown origin) transfected in mouse BA/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	2018	Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
AID660687	Inhibition of CSF-1R	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
AID641359	Oral bioavailability in rat at 2 to 5 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639905	Inhibition of PDGFRbeta phosphorylation by cell based assay	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639910	Clearance in rat at 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639921	Half life in rat at 2 mg/kg, po	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641358	Half life in dog at 2 mg/kg, po	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641360	Oral bioavailability in dog at 2 to 5 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639906	Inhibition of VEGFR3 phosphorylation by cell based assay	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639907	Inhibition of CSF1R phosphorylation by cell based assay	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641370	Antitumor activity against rat C6 cells xenografted in nude mouse assessed as tumor growth inhibition at 12.5 to 50 mg/kg bid for 22 days	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639912	Clearance in dog at 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641372	Antitumor activity against human Calu6 cells xenografted in nude mouse assessed as tumor growth inhibition at 50 mg/kg bid	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639916	Volume of distribution at steady state in rat at 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID1386987	Cytotoxicity in mouse parental BA/F3 cells incubated for 72 hrs by MTS assay	2018	Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
AID641371	Antitumor activity against human Calu6 cells xenografted in nude mouse assessed as tumor growth inhibition at 12.5 mg/kg bid	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641375	Inhibition of PDGFRalpha phosphorylation in C6 cells xenografted in nude mouse lungs at 3 to 50 mg/kg bid after 10 hrs by Western blot analysis	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID1386991	Inhibition of KDR (unknown origin) transfected in mouse BA/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	2018	Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19	Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
AID639909	Inhibition of FLT3 phosphorylation by cell based assay	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID1557185	Inhibition of FLT3 (unknown origin)	2019	Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19	Design, synthesis, and biological evaluation of 4-((6,7-dimethoxyquinoline-4-yl)oxy)aniline derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia.
AID639908	Inhibition of CYP2C9	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID639917	Volume of distribution at steady state in dog at 2 mg/kg	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641367	Inhibition of PDGFRalpha phosphorylation by cell based assay	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641374	Inhibition of VEGFR2 phosphorylation in C6 cells xenografted in nude mouse lungs at 3 to 50 mg/kg bid after 10 hrs by Western blot analysis	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641365	Inhibition of human ERG	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641364	Fraction unbound in dog serum	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641363	Fraction unbound in human serum	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID641366	Clearance in rat hepatocytes assessed per million cells	2012	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1	Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
AID657731	Inhibition of Flt3	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
AID660686	Inhibition of KDR	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (71.43)	24.3611
2020's	2 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
imatinib [no description available]	2.17	1	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	2.07	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
su 11248 [no description available]	2.17	1	monocarboxylic acid amide; pyrroles	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist
regorafenib [no description available]	2.17	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; monofluorobenzenes; phenylureas; pyridinecarboxamide	antineoplastic agent; hepatotoxic agent; tyrosine kinase inhibitor
cabozantinib cabozantinib: a multikinase inhibitor. cabozantinib : A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.	2.21	1	aromatic ether; dicarboxylic acid diamide; organofluorine compound; quinolines	antineoplastic agent; tyrosine kinase inhibitor
gsk 1363089 GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first source	2.21	1	aromatic ether

Condition	Relationship Strength	Studies
Gastrointestinal Stromal Neoplasm [description not available]	2.17	1
Cancer of Gastrointestinal Tract [description not available]	2.17	1
Gastrointestinal Stromal Tumors All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).	2.17	1
Acute Myelogenous Leukemia [description not available]	2.21	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.21	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

azd2932

Description

Cross-References

Synonyms (26)

Research Excerpts

Bioavailability

Dosage Studied

Protein Targets (15)

Potency Measurements

Inhibition Measurements

Other Measurements

Biological Processes (296)

Molecular Functions (72)

Ceullar Components (47)

Bioassays (46)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.43

Study Types

azd2932

Description

Cross-References

Synonyms (26)

Research Excerpts

Bioavailability

Dosage Studied

Protein Targets (15)

Potency Measurements

Inhibition Measurements

Other Measurements

Biological Processes (296)

Molecular Functions (72)

Ceullar Components (47)

Bioassays (46)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.43

Study Types

Related Drugs (6)

Related Conditions (8)