Assay ID | Title | Year | Journal | Article |
AID123408 | In vitro anticancer activity against 5 B6D2F-1 mice bearing P388 leukemia measured by the toxicity death at an intravenous dose of 16(mg/kg).. | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID111057 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 1 at an intravenous dose of 16(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID111062 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 1 at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID266296 | Antiproliferative activity against human CCRF-CEM cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID116324 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the increase in lifespan at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID81631 | In vitro cytotoxicity against human leukemic HL-60 cell line. | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID53599 | Cytotoxicity against human Glioblastoma multiformi DBTRG | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID320265 | Displacement of ethidium bromide from calf thymus DNA | 2008 | Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
| Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives. |
AID266301 | Antiproliferative activity against human MX1 cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID367776 | Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID111071 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 11 at an intravenous dose of 16(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID266300 | Antiproliferative activity against human HCT116 cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID55287 | Percentage of protein-linked DNA breaks; Not determined | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID53600 | The compound was tested for the cytotoxicity DC-3F cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID85751 | Cytotoxicity against human colon HT-29 cell line | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID367772 | Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID111213 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 7 at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID81469 | In vitro inhibition of human leukemic HL-60 cell growth in culture | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID248840 | Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. |
AID367774 | Ratio of IC50 for vinblastine-resistant human CCRF-CEM cells to IC50 for human CCRF-CEM cells | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID110721 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the Average survival time(days) at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID111077 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 7 at an intravenous dose of 16(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID248807 | Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. |
AID53621 | The compound was tested for the cytotoxicity against human leukemic DC-3F/ADII cell lines, activity is expressed as IC50 values. | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID111217 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 9 at an intravenous dose of 16(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID116325 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the increase in lifespan at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID57198 | In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenation | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID248302 | Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. |
AID266299 | Antiproliferative activity against human A549 cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID367775 | Cytotoxicity against human MX1 cells after 72 hrs by SRB assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID111218 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 9 at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID106083 | Cytotoxicity against human Breast carcinoma MX-1; Not determined | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID202622 | The compound was tested for the cytotoxicity against S180 cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID367771 | Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID41970 | Cytotoxicity against human nasopharyngeal carcinoma BM-1 | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID123405 | In vitro anticancer activity against 4 B6D2F-1 mice bearing P388 leukemia measured by the toxicity death at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID248484 | Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. |
AID428404 | Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT-tetrazolium assay | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7
| Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings. |
AID428406 | Antitumor activity in human CCRF-CEM cells xenografted mouse at 2 mg/kg, iv qd for 3 days | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7
| Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings. |
AID99086 | The compound was tested for the cytotoxicity against L1210 cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID47003 | The compound was tested for the cytotoxicity against human leukemic CEM/VBL cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID111067 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 11 at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID81346 | Cytotoxicity against human nasopharyngeal carcinoma HONE-1 | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID266298 | Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID111068 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 11 at an intravenous dose of 30(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID367770 | Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID116323 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the increase in lifespan at an intravenous dose of 16(mg/kg).. | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID86721 | Cytotoxicity against human hepatoma Hepa-G2 | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID110724 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average survival time(days) at an intravenous dose of 16(mg/kg).. | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID111059 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 1 at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID110720 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the Average survival time(days) at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID367773 | Ratio of IC50 for taxol-resistant human CCRF-CEM cells to IC50 for human CCRF-CEM cells | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. |
AID248552 | Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM); ND = Not determined | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
| Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. |
AID123410 | In vitro anticancer activity against 5 B6D2F-1 mice bearing P388 leukemia measured by the toxicity death at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID43838 | The compound was tested for the cytotoxicity against human leukemic CCRF-CEM cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
AID320266 | Ratio of Qmax for calf thymus DNA to Q50 for calf thymus DNA | 2008 | Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
| Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives. |
AID210186 | In vitro cytotoxicity against human TSGH | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID266297 | Antiproliferative activity against human taxol resistant CCRF-CEM cell line | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. |
AID43360 | Cytotoxicity against human T-cell acute lymphocytic leukemia CCRF-CEM | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation. |
AID111210 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 7 at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID111385 | In vitro anticancer activity against B6D2F-1 mice bearing P388 leukemia measured by the average weight change(g) after day 9 at an intravenous dose of 22(mg/kg). | 1999 | Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23
| Synthesis and structure-activity relationships of potential anticancer agents: alkylcarbamates of 3-(9-acridinylamino)-5-hydroxymethylaniline. |
AID47006 | The compound was tested for the cytotoxicity against human leukemic CEM/VM-1 cell lines | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |