| Assay ID | Title | Year | Journal | Article |
|---|
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID148828 | Tested for competitive covalent binding of compound against k opioid receptor in guinea pig brain membrane using [3H]U-69593 as radioligand | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID148294 | Agonist selectivity for kappa opioid receptor in the naltrindole-treated mice. Subcutaneous dose of 12.25 umol/kg of norBNI was administered | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID224579 | Antagonist potency of compound was evaluated towards mu receptor in presence of agonist DPDPE by using Mouse Tail-Flick Assay | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID140725 | Dose required to produce equivalent antagonism of U50,488 antinociception was determined in tail-flick assay. Compound dose at peak time of 18 h was reported. Time duration is 72-96 h | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID132247 | Effective dose required to produce equivalent antagonism of U50,488 antinociception in abdominal-stretch assay. Value at peak time of 30 min was reported at <4 h | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID131750 | Tested for antinociceptive potency by Mouse abdominal stretch assay | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID76374 | Tested for agonist potency by conducting tests on electrically stimulated guinea pig ileal longitudinal muscle preparation | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID149219 | Ratio of ED50 of compound to delta opioid receptor antagonist naltrindole (NTI) at 44.44 umol/kg administarted sc | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148322 | Antagonist potency of compound was evaluated towards kappa receptor in presence of agonist U50,488 by using Mouse Tail-Flick Assay | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148504 | Agonist selectivity for delta opioid receptor in the naltrindole-treated mice Subcutaneous dose of 44.44 umol/kg of naltrindole was administered | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID149102 | Antagonist potency of compound was evaluated towards delta receptor in presence of agonist morphine by using Mouse Tail-Flick Assay | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID224577 | Antagonist selectivity of mu opioid receptor in treated mice at subcutaneous dose of 0.53 umol/kg at 30 min peak time by mouse tail-flick assay | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID149623 | Binding affinity of compound towards delta receptor by using radioligand [SHIDPDPE on guinea pig brain membranes | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148556 | Binding affinity kappa opioid receptor in guinea pig brain membranes, using 1 nM [3H]U-69593 as radioligand | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID149963 | Agonist potency of compound was evaluated towards kappa opioid receptor in absence of antagonist in guinea pig ileum(GPI) | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148558 | Binding affinity of compound towards kappa receptor by using radioligand [3H]-U-69,593 on guinea pig brain membranes | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148402 | Bmax for kappa opioid receptor in guinea pig brain membranes [3H]U-69593 as radioligand | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID148425 | Ratio of ED50 of compound to kappa opioid receptor antagonist norbinaltorphimine (nor-BNI) at conc. of 12.25 umol/kg administarted sc | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID149621 | Binding affinity for delta opioid receptor in guinea pig brain membranes, using 2 nM [3H]DPDPE as radioligand | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID80130 | Tested for wash-resistant activity after forty post-washes (for removal of nor BNI) with Kreb's buffer pre-incubated with compound | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID77759 | Agonist potency was determined in electrically stimulated guinea pig ileal longitudinal muscle preparation, pre-incubated with 5 and 20 nM norBNI for 15 min | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID141634 | Ratio of ED50 of compound to mu opioid receptor antagonist beta-funaltrexamine (FMN) at 10.18 umol/kg administarted sc | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID78862 | Compound was evaluated for In vivo antagonist activity towards guinea pig ileum(GPI) | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID138852 | Binding affinity of compound towards mu receptor by using radioligand [3H]DAMG0 on guinea pig brain membranes | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID132339 | Compound was evaluated for In vivo antagonist activity towards Mouse vas deferens(MVD) | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148506 | Antagonist selectivity for delta opioid receptor in treated mice at subcutaneous dose of 0.53 umol/kg at 20 min peak time by mouse tail-flick assay | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID80129 | Tested for wash-resistant activity after forty post-washes (for removal of naltrexone) with Kreb's buffer pre-incubated with compound | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID141626 | Agonist selectivity for mu opioid receptor in the beta-funaltrexamine-treated mice Subcutaneous dose of 20.36 umol/kg of beta-FNA was administered | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID132848 | Tested for agonist potency by conducting tests on mouse vas deferens preparation | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID80132 | Tested for wash-resistant activity by incubating guinea pig ileal longitudinal muscle (pre-treated with the compound) with naltrexone (500 nM).Number of determinations, n=3 | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID80134 | Tested for wash-resistant activity by incubating guinea pig ileal longitudinal muscle (pre-treated with the compound) with nor BNI (20 nM).Number of determinations, n=3 | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID80135 | Tested for wash-resistant activity in guinea pig ileal longitudinal muscle preparation, after forty washes with Kreb's buffer pre-incubated with compound | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID224562 | Binding affinity for mu opioid receptor in guinea pig brain membranes, using 2 nM [3H]-DAMGO as radioligand | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| AID129605 | Compound was evaluated for Antinociceptive Potency by using mouse abdominal stretch assay after sc administration | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. |
| AID148303 | Antagonist selectivity of kappa opioid receptor in treated mice at subcutaneous dose of 0.53 umol/kg at 20 min peak time by mouse tail-flick assay | 1994 | Journal of medicinal chemistry, Dec-23, Volume: 37, Issue:26
| kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |