| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
minoxidil
Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371). minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. | 2.08 | 1 | 0 | dialkylarylamine;
tertiary amino compound | |
spiperone
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.. spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively. | 2.08 | 1 | 0 | aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound | alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist |
pilocarpine hydrochloride
pilocarpine hydrochloride : The hydrochloride salt of (+)-pilocarpine, a medication used to treat increased pressure inside the eye and dry mouth. | 2.08 | 1 | 0 | hydrochloride | |
rhein
[no description available] | 2.08 | 1 | 0 | dihydroxyanthraquinone | |
bethanechol chloride
bethanechol chloride : The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. | 2.08 | 1 | 0 | carbamate ester;
chloride salt;
quaternary ammonium salt | muscarinic agonist |
n-(cyclohexylthio)phthalimide
N-(cyclohexylthio)phthalimide: water pollutant | 2.08 | 1 | 0 | | |
oxcarbazepine
Oxcarbazepine: A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4.. oxcarbazepine : A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. | 2.08 | 1 | 0 | cyclic ketone;
dibenzoazepine | anticonvulsant;
drug allergen |
ergocornine
ergocornine: a component of ergotoxine; minor descriptor (75-86); on-line & INDEX MEDICUS search ERGOLINES (75-86); RN given refers to ((5'alpha)-isomer). ergocornine : Ergotaman bearing a hydroxy group at the 12' position, isopropyl groups at the 2' and 5'alpha positions, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. | 2.08 | 1 | 0 | ergot alkaloid | |
butyrylcholine chloride
[no description available] | 2.08 | 1 | 0 | | |
monopentyl phthalate
monopentyl phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of pentanol. | 2.08 | 1 | 0 | phthalic acid monoester | anti-estrogen;
rat metabolite;
xenobiotic metabolite |
7-amino-4-trifluoromethylcoumarin
coumarin 151: structure in first source | 2.08 | 1 | 0 | 7-aminocoumarins | fluorochrome |
alpha-(n6-adenyl)styrene oxide
alpha-(N6-adenyl)styrene oxide: structure given in first source; RN given refers to compound with no isomeric designation | 2.08 | 1 | 0 | | |
2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide;
thiophenes | |
1-(1,3-benzodioxol-5-ylmethyl)-3-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-2-indolone
[no description available] | 2.08 | 1 | 0 | aromatic ketone | |
6-ethyl-N-[2-(4-methoxyphenyl)ethyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[no description available] | 2.08 | 1 | 0 | triazolopyrimidines | |
7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propan-2-ylthio)purine-2,6-dione
[no description available] | 2.08 | 1 | 0 | oxopurine | |
2-[[5-(1-benzotriazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-N-[(4-fluorophenyl)methyl]-N-phenylacetamide
[no description available] | 2.08 | 1 | 0 | benzotriazoles | |
3-[(1-cyclopentyl-5-tetrazolyl)-[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-7-methyl-1H-quinolin-2-one
[no description available] | 2.08 | 1 | 0 | piperazines | |
3-[[2-[[5-[(4-cyanophenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]benzoic acid methyl ester
[no description available] | 2.08 | 1 | 0 | amidobenzoic acid | |
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone
[no description available] | 2.08 | 1 | 0 | piperazines;
pyridines | |
N-[2-[(3-cyano-6-ethoxy-2-quinolinyl)amino]ethyl]propanamide
[no description available] | 2.08 | 1 | 0 | aminoquinoline | |
4-[3-(1,3-dioxo-2-isoindolyl)propylamino]-2-methylisoindole-1,3-dione
[no description available] | 2.08 | 1 | 0 | phthalimides | |
9-[3-(4-acetyl-3,5-dimethyl-1-pyrazolyl)-2-hydroxypropyl]-6-methyl-3,4-dihydro-2H-carbazol-1-one
[no description available] | 2.08 | 1 | 0 | carbazoles | |
1-phenyl-4-[[1-(phenylmethyl)-5-tetrazolyl]-(3-pyridinyl)methyl]piperazine
[no description available] | 2.08 | 1 | 0 | piperazines | |
1-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(2-furanylmethyl)-3-phenylurea
[no description available] | 2.08 | 1 | 0 | quinolines | |
N-(2-furanylmethyl)-2-[(4-methoxyphenyl)sulfonylamino]benzamide
[no description available] | 2.08 | 1 | 0 | sulfonamide | |
N-methyl-N-[5-(5-methyl-2-pyrazinyl)-1,3,4-thiadiazol-2-yl]-2-oxolanecarboxamide
[no description available] | 2.08 | 1 | 0 | pyrazines | |
2-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-3-ethyl-4-quinazolinone
[no description available] | 2.08 | 1 | 0 | quinazolines | |
2-[[5-(4-methylphenyl)-3-thiazolo[2,3-c][1,2,4]triazolyl]thio]-N-(6-methyl-2-pyridinyl)acetamide
[no description available] | 2.08 | 1 | 0 | organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound | |
4-amino-N5-[2-(2-methoxyethylamino)-1-(5-methyl-2-furanyl)-2-oxoethyl]-N5-(thiophen-2-ylmethyl)isothiazole-3,5-dicarboxamide
[no description available] | 2.08 | 1 | 0 | organonitrogen compound;
organooxygen compound | |
pilocarpine nitrate
[no description available] | 2.08 | 1 | 0 | | |
7-diethylaminocoumarin-3-carboxylic acid
[no description available] | 2.08 | 1 | 0 | | |
5-(4-methoxyphenyl)-7-(4-methylphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine
[no description available] | 2.08 | 1 | 0 | methoxybenzenes | |
cyclopropanecarboxylic acid [5-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-2-ethoxyphenyl] ester
[no description available] | 2.08 | 1 | 0 | pyranopyrazole | |
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid cyclohexyl ester
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
2-(3-methylphenyl)sulfonyl-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetonitrile
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
5-(3-methoxyphenyl)-N-(2-oxolanylmethyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyrimidines | |
2-(4-bromophenyl)-4-methyl-1H-pyrazol-5-one
[no description available] | 2.08 | 1 | 0 | pyrazoles;
ring assembly | |
2-[(4-fluoro-3-methylphenyl)sulfonylamino]acetic acid
[no description available] | 2.08 | 1 | 0 | sulfonamide | |
4-(1H-benzimidazol-2-yl)quinoline
[no description available] | 2.08 | 1 | 0 | quinolines | |
2-[[2-(5,6-dimethyl-1-benzimidazolyl)-1-oxoethyl]amino]benzoic acid methyl ester
[no description available] | 2.08 | 1 | 0 | amidobenzoic acid | |
1-(4-ethylphenyl)-N-(3-pyridinylmethyl)methanamine
[no description available] | 2.08 | 1 | 0 | aromatic amine | |
1-(4-ethoxyphenyl)-3-(6-quinoxalinyl)urea
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
3-methyl-5-propyl-7-furo[3,2-g][1]benzopyranone
[no description available] | 2.08 | 1 | 0 | psoralens | |
4-(1,3-benzothiazol-2-yl)-N-phenyl-1-piperazinecarboxamide
[no description available] | 2.08 | 1 | 0 | N-arylpiperazine | |
2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetic acid methyl ester
[no description available] | 2.08 | 1 | 0 | monocarboxylic acid | |
5-bromo-N-(pyridin-4-ylmethyl)-2-thiophenesulfonamide
[no description available] | 2.08 | 1 | 0 | thiophenes | |
LSM-16463
[no description available] | 2.08 | 1 | 0 | pyrazoles;
ring assembly | |
4-[2-(9-methyl-6-indolo[3,2-b]quinoxalinyl)ethyl]morpholine
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
4-[[[3-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]benzoic acid ethyl ester
[no description available] | 2.08 | 1 | 0 | benzamides | |
5-(2,3-dihydroindol-1-ylsulfonyl)-1,3-diethyl-2-benzimidazolone
[no description available] | 2.08 | 1 | 0 | benzimidazoles | |
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide
[no description available] | 2.08 | 1 | 0 | piperazines | |
N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyridopyrimidine | |
N-[2-[4-[(4-chlorophenyl)-oxomethyl]-1-piperazinyl]phenyl]-1,3-benzodioxole-5-carboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide | |
[2-(4-methoxyphenyl)-6-methyl-4-quinolinyl]-(4-morpholinyl)methanone
[no description available] | 2.08 | 1 | 0 | quinolines | |
2-(2-furanyl)-5-methyl-6-(phenylmethyl)-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
[no description available] | 2.08 | 1 | 0 | triazolopyrimidines | |
1-[4-[(2-amino-5-thiazolyl)methyl]phenyl]ethanone
[no description available] | 2.08 | 1 | 0 | aromatic ketone | |
N-[2-[4-[(4-chlorophenyl)-oxomethyl]-1-piperazinyl]phenyl]-2-benzofurancarboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide;
furans | |
2-(3,5-dimethylphenoxy)-N-[3-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]phenyl]acetamide
[no description available] | 2.08 | 1 | 0 | anilide | |
5-(2-furanyl)-N-[1-[(2-methylphenyl)methyl]-3-pyrazolyl]-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyrazolopyrimidine | |
1,4-dioxa-8-azaspiro[4.5]decan-8-yl-(5,7-diphenyl-2-pyrazolo[1,5-a]pyrimidinyl)methanone
[no description available] | 2.08 | 1 | 0 | pyrimidines | |
4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dione
[no description available] | 2.08 | 1 | 0 | phthalimides | |
N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-[(6-methyl-1H-benzimidazol-2-yl)thio]acetamide
[no description available] | 2.08 | 1 | 0 | pyrazoles;
ring assembly | |
2-(1-benzimidazolyl)acetic acid [2-[1-(4-methoxyphenyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester
[no description available] | 2.08 | 1 | 0 | alpha-amino acid ester | |
2-(3-oxo-2,4-dihydro-1H-quinoxalin-2-yl)-N-phenylacetamide
[no description available] | 2.08 | 1 | 0 | amino acid amide | |
6-amino-5-cyano-4-(2,4-dimethoxyphenyl)-2-(2-ethoxy-2-oxoethyl)-4H-pyran-3-carboxylic acid ethyl ester
[no description available] | 2.08 | 1 | 0 | dimethoxybenzene | |
2-chloro-5-[[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]amino]benzoic acid methyl ester
[no description available] | 2.08 | 1 | 0 | amidobenzoic acid | |
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-methoxy-4-propan-2-yloxybenzamide
[no description available] | 2.08 | 1 | 0 | benzodioxine | |
3-(3,4-dihydro-2H-quinolin-1-ylmethyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
[no description available] | 2.08 | 1 | 0 | quinolines | |
benzoic acid [5-(6-benzamido-9-purinyl)-3-fluoro-4-hydroxy-2-oxolanyl]methyl ester
[no description available] | 2.08 | 1 | 0 | 3'-deoxyribonucleoside;
purines | |
2-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonylamino)benzoic acid thiophen-2-ylmethyl ester
[no description available] | 2.08 | 1 | 0 | benzoate ester | |
3,5-dimethyl-1-phenyl-4-pyrazolecarboxylic acid [2-[4-amino-1-methyl-3-(2-methylpropyl)-2,6-dioxo-5-pyrimidinyl]-2-oxoethyl] ester
[no description available] | 2.08 | 1 | 0 | pyrazoles;
ring assembly | |
9-chloro-6-methylindolo[3,2-b]quinoxaline
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
3-chloro-N-[2-[4-(4-fluorophenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]benzamide
[no description available] | 2.08 | 1 | 0 | piperazines | |
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
[no description available] | 2.08 | 1 | 0 | oxadiazole;
ring assembly | |
2-cyclopentyl-4-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-9-methyl-1-pyrido[3,4-b]indolone
[no description available] | 2.08 | 1 | 0 | beta-carbolines | |
N-(3-chlorophenyl)-5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-3-methyl-2-benzofurancarboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide;
furans | |
[4-[6-(4-morpholinyl)-3-pyridazinyl]-1-piperazinyl]-(2-pyridin-4-yl-4-quinolinyl)methanone
[no description available] | 2.08 | 1 | 0 | quinolines | |
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(3-methyl-4-oxo-1-phthalazinyl)acetamide
[no description available] | 2.08 | 1 | 0 | phthalazines | |
5-bromo-N-[2-(6,7-dimethyl-2-oxo-1H-quinolin-3-yl)ethyl]-2-furancarboxamide
[no description available] | 2.08 | 1 | 0 | quinolines | |
3-(2-chlorophenyl)-5-methyl-N-[3-(3-methyl-2-imidazo[1,2-a]pyrimidinyl)phenyl]-4-isoxazolecarboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide | |
7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one
[no description available] | 2.08 | 1 | 0 | pyrrolopyridine | |
2-furanyl-[4-(4-tetrazolo[1,5-a]quinoxalinyl)-1-piperazinyl]methanone
[no description available] | 2.08 | 1 | 0 | N-arylpiperazine | |
[4-(2-pyrimidinyl)-1-piperazinyl]-[1-[4-(2-pyrimidinyl)-1-piperazinyl]-4-isoquinolinyl]methanone
[no description available] | 2.08 | 1 | 0 | piperazines;
pyridines | |
N-[[4-(dimethylamino)phenyl]methyl]-3-ethyl-N-(2-furanylmethyl)-5-methyl-4-oxo-6-thieno[2,3-d]pyrimidinecarboxamide
[no description available] | 2.08 | 1 | 0 | organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound | |
N-(2,3-dimethylphenyl)-3-methyl-5-(4-morpholinylsulfonyl)-2-benzofurancarboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide;
furans | |
N-[(2-methyl-4-thiazolyl)methyl]-4-phenoxybenzenesulfonamide
[no description available] | 2.08 | 1 | 0 | aromatic ether | |
4-[[3-[(2-furanylmethylamino)-oxomethyl]-7-methoxy-1-benzopyran-2-ylidene]amino]benzoic acid
[no description available] | 2.08 | 1 | 0 | 1-benzopyran | |
N-(2-furanylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]-2-imino-10-methyl-5-oxo-3-dipyrido[3,4-c-1',2'-f]pyrimidinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyridopyrimidine | |
1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-3-piperidinecarboxamide
[no description available] | 2.08 | 1 | 0 | benzodioxine | |
4-[4-oxo-2-[[2-oxo-2-[(phenylmethyl)amino]ethyl]thio]-3-quinazolinyl]-1-piperidinecarboxylic acid ethyl ester
[no description available] | 2.08 | 1 | 0 | quinazolines | |
8-(2-propoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
[no description available] | 2.08 | 1 | 0 | quinolines | |
N-[4-[5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]-4-pyridinecarboxamide
[no description available] | 2.08 | 1 | 0 | aromatic amide | |
3-(5,7-diphenyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-propanol
[no description available] | 2.08 | 1 | 0 | triazolopyrimidines | |
methysergide maleate
[no description available] | 2.08 | 1 | 0 | ergoline alkaloid | |
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5. | 2.08 | 1 | 0 | 7-hydroxyflavonol;
pentahydroxyflavone | angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent |
N-(4-bromo-3-methylphenyl)-2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[no description available] | 2.08 | 1 | 0 | triazolopyrimidines | |
4-[[[2-(4-methoxyphenyl)-3-oxo-1H-isoindol-4-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester
[no description available] | 2.08 | 1 | 0 | isoindoles | |
1,5-dimethyl-4-oxo-N-[2-(3-thiophenyl)ethyl]-2-pyrrolo[3,2-c]quinolinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyrroloquinoline | |
4-[[[1-[[2-(3-chlorophenyl)-5-methyl-4-oxazolyl]methyl]-3-piperidinyl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester
[no description available] | 2.08 | 1 | 0 | 1,3-oxazoles | |
1,5-dimethyl-4-oxo-N-[3-(4-propyl-1-piperazinyl)propyl]-2-pyrrolo[3,2-c]quinolinecarboxamide
[no description available] | 2.08 | 1 | 0 | pyrroloquinoline | |
4-(4-tetrazolo[1,5-a]quinoxalinyl)morpholine
[no description available] | 2.08 | 1 | 0 | quinoxaline derivative | |
1-cyclopentyl-1-[(4-oxo-1H-quinazolin-2-yl)methyl]-3-(phenylmethyl)urea
[no description available] | 2.08 | 1 | 0 | quinazolines | |
7-hydroxyquinoline
7-hydroxyquinoline: structure in first source. quinolin-7-ol : A monohydroxyquinoline carrying a hydroxy substituent at position 7. | 2.08 | 1 | 0 | monohydroxyquinoline | |