Kallikrein-4

A kallikrein-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5K2]

EC 3.4.21.-;
Enamel matrix serine proteinase 1;
Kallikrein-like protein 1;
KLK-L1;
Prostase;
Serine protease 17

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile	Homo sapiens (human)	IC50	14.4544	1	1
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile	Homo sapiens (human)	IC50	9.7724	1	1
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile	Homo sapiens (human)	IC50	177.8280	1	1
grassystatin a	Homo sapiens (human)	IC50	10.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
serine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 1 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]

This protein is active in 1 target(s):

Target	Category	Definition
secretory granule	cellular component	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]

This protein is involved in 4 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
biomineral tissue development	biological process	Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. [PMID:15132736]
amelogenesis	biological process	The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
extracellular matrix disassembly	biological process	A process that results in the breakdown of the extracellular matrix. [GOC:jid]