2-demethylthiocolchicine profile

2-Demethylthiocolchicine is a synthetic analog of colchicine, a natural product isolated from the autumn crocus plant. It is a potent inhibitor of tubulin polymerization, which is a key process in cell division and microtubule assembly. 2-demethylthiocolchicine has been investigated for its potential therapeutic applications in various conditions, including cancer, inflammation, and gout. It is studied because it exhibits a lower toxicity profile than colchicine and may have improved therapeutic efficacy in certain applications. Research on 2-demethylthiocolchicine focuses on understanding its mechanism of action, pharmacokinetic properties, and its potential as a novel drug candidate.'

2-demethylthiocolchicine: RN & structure given in first source; RN not in Chemline 10/85 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	55708
CHEMBL ID	277239
MeSH ID	M0134638

Synonym
nsc 369937
brn 3176298
87424-26-8
2-demethylthiocolchicine
acetamide, n-[(7s)-5,6,7,9-tetrahydro-2-hydroxy-1,3-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
n-[(7s)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide
CHEMBL277239 ,
n-((s)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
bdbm50064482
n-(2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
4-14-00-00957 (beilstein handbook reference)
2-demethyl thiocolchicine
DTXSID40236341

Protein Targets (16)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tubulin alpha-1A chain	Sus scrofa (pig)	IC50 (µMol)	1.5136	0.0067	2.1603	10.0000	AID214887
Tubulin beta-4A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin beta chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	2.0529	10.0000	AID214548
Tubulin alpha-3C chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin alpha-1B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin alpha-4A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin beta-4B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin beta-3 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.8945	10.0000	AID214548
Tubulin beta-2A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin beta-8 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin alpha-3E chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin alpha-1A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin alpha-1C chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214548
Tubulin beta-6 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin beta-2B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214548
Tubulin beta-1 chain	Homo sapiens (human)	IC50 (µMol)	1.7500	0.0005	1.9870	10.0000	AID214548; AID241148
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (51)

Process	via Protein(s)	Taxonomy
negative regulation of microtubule polymerization	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4A chain	Homo sapiens (human)
odontoblast differentiation	Tubulin beta chain	Homo sapiens (human)
microtubule-based process	Tubulin beta chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin beta chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta chain	Homo sapiens (human)
regulation of synapse organization	Tubulin beta chain	Homo sapiens (human)
spindle assembly	Tubulin beta chain	Homo sapiens (human)
cell division	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1B chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1B chain	Homo sapiens (human)
cell division	Tubulin alpha-1B chain	Homo sapiens (human)
cellular response to interleukin-4	Tubulin alpha-1B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-4A chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta-4B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-3 chain	Homo sapiens (human)
axon guidance	Tubulin beta-3 chain	Homo sapiens (human)
netrin-activated signaling pathway	Tubulin beta-3 chain	Homo sapiens (human)
dorsal root ganglion development	Tubulin beta-3 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-3 chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2A chain	Homo sapiens (human)
oocyte maturation	Tubulin beta-8 chain	Homo sapiens (human)
spindle assembly involved in female meiosis	Tubulin beta-8 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-8 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-8 chain	Homo sapiens (human)
biological_process	Tubulin alpha-3E chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3E chain	Homo sapiens (human)
neuron migration	Tubulin alpha-1A chain	Homo sapiens (human)
startle response	Tubulin alpha-1A chain	Homo sapiens (human)
intracellular protein transport	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1A chain	Homo sapiens (human)
centrosome cycle	Tubulin alpha-1A chain	Homo sapiens (human)
smoothened signaling pathway	Tubulin alpha-1A chain	Homo sapiens (human)
memory	Tubulin alpha-1A chain	Homo sapiens (human)
adult locomotory behavior	Tubulin alpha-1A chain	Homo sapiens (human)
visual learning	Tubulin alpha-1A chain	Homo sapiens (human)
response to mechanical stimulus	Tubulin alpha-1A chain	Homo sapiens (human)
glial cell differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
gene expression	Tubulin alpha-1A chain	Homo sapiens (human)
dentate gyrus development	Tubulin alpha-1A chain	Homo sapiens (human)
cerebellar cortex morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
pyramidal neuron differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
cerebral cortex development	Tubulin alpha-1A chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1A chain	Homo sapiens (human)
response to tumor necrosis factor	Tubulin alpha-1A chain	Homo sapiens (human)
locomotory exploration behavior	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule polymerization	Tubulin alpha-1A chain	Homo sapiens (human)
forebrain morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
homeostasis of number of cells within a tissue	Tubulin alpha-1A chain	Homo sapiens (human)
regulation of synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
cell division	Tubulin alpha-1A chain	Homo sapiens (human)
neuron apoptotic process	Tubulin alpha-1A chain	Homo sapiens (human)
motor behavior	Tubulin alpha-1A chain	Homo sapiens (human)
cellular response to calcium ion	Tubulin alpha-1A chain	Homo sapiens (human)
organelle transport along microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
neuron projection arborization	Tubulin alpha-1A chain	Homo sapiens (human)
response to L-glutamate	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1C chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1C chain	Homo sapiens (human)
cell division	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-6 chain	Homo sapiens (human)
neuron migration	Tubulin beta-2B chain	Homo sapiens (human)
microtubule-based process	Tubulin beta-2B chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2B chain	Homo sapiens (human)
modulation of chemical synaptic transmission	Tubulin beta-2B chain	Homo sapiens (human)
positive regulation of axon guidance	Tubulin beta-2B chain	Homo sapiens (human)
embryonic brain development	Tubulin beta-2B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2B chain	Homo sapiens (human)
platelet formation	Tubulin beta-1 chain	Homo sapiens (human)
thyroid gland development	Tubulin beta-1 chain	Homo sapiens (human)
microtubule polymerization	Tubulin beta-1 chain	Homo sapiens (human)
spindle assembly	Tubulin beta-1 chain	Homo sapiens (human)
thyroid hormone transport	Tubulin beta-1 chain	Homo sapiens (human)
platelet aggregation	Tubulin beta-1 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (21)

Process	via Protein(s)	Taxonomy
GTPase activity	Tubulin beta-4A chain	Homo sapiens (human)
calcium ion binding	Tubulin beta-4A chain	Homo sapiens (human)
protein binding	Tubulin beta-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
GTP binding	Tubulin beta-4A chain	Homo sapiens (human)
GTPase activity	Tubulin beta chain	Homo sapiens (human)
structural molecule activity	Tubulin beta chain	Homo sapiens (human)
protein binding	Tubulin beta chain	Homo sapiens (human)
protein domain specific binding	Tubulin beta chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin beta chain	Homo sapiens (human)
GTPase activating protein binding	Tubulin beta chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta chain	Homo sapiens (human)
protein-containing complex binding	Tubulin beta chain	Homo sapiens (human)
metal ion binding	Tubulin beta chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta chain	Homo sapiens (human)
GTP binding	Tubulin beta chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3C chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTPase activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1B chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-4A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-4A chain	Homo sapiens (human)
protein kinase binding	Tubulin alpha-4A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-4A chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-4B chain	Homo sapiens (human)
protein binding	Tubulin beta-4B chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta-4B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-4B chain	Homo sapiens (human)
unfolded protein binding	Tubulin beta-4B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
GTP binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-3 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
protein binding	Tubulin beta-3 chain	Homo sapiens (human)
GTP binding	Tubulin beta-3 chain	Homo sapiens (human)
peptide binding	Tubulin beta-3 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-3 chain	Homo sapiens (human)
netrin receptor binding	Tubulin beta-3 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2A chain	Homo sapiens (human)
protein binding	Tubulin beta-2A chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
GTP binding	Tubulin beta-2A chain	Homo sapiens (human)
molecular_function	Tubulin beta-8 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-8 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-8 chain	Homo sapiens (human)
GTP binding	Tubulin beta-8 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
molecular_function	Tubulin alpha-3E chain	Homo sapiens (human)
protein binding	Tubulin alpha-3E chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3E chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1A chain	Homo sapiens (human)
protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1A chain	Homo sapiens (human)
identical protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein-containing complex binding	Tubulin alpha-1A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin alpha-1A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1C chain	Homo sapiens (human)
protein binding	Tubulin alpha-1C chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
molecular_function	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-6 chain	Homo sapiens (human)
protein binding	Tubulin beta-6 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-6 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
GTP binding	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2B chain	Homo sapiens (human)
protein binding	Tubulin beta-2B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2B chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin beta-2B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
GTP binding	Tubulin beta-2B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-1 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-1 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
GTP binding	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Process	via Protein(s)	Taxonomy
nucleus	Tubulin beta-4A chain	Homo sapiens (human)
cytosol	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
axoneme	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
internode region of axon	Tubulin beta-4A chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-4A chain	Homo sapiens (human)
myelin sheath	Tubulin beta-4A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin beta chain	Homo sapiens (human)
nuclear envelope lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
cytosol	Tubulin beta chain	Homo sapiens (human)
cytoskeleton	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin beta chain	Homo sapiens (human)
cell body	Tubulin beta chain	Homo sapiens (human)
membrane raft	Tubulin beta chain	Homo sapiens (human)
intercellular bridge	Tubulin beta chain	Homo sapiens (human)
extracellular exosome	Tubulin beta chain	Homo sapiens (human)
mitotic spindle	Tubulin beta chain	Homo sapiens (human)
protein-containing complex	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule	Tubulin alpha-3C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1B chain	Homo sapiens (human)
extracellular region	Tubulin alpha-4A chain	Homo sapiens (human)
cytosol	Tubulin alpha-4A chain	Homo sapiens (human)
cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-4A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta-4B chain	Homo sapiens (human)
nucleus	Tubulin beta-4B chain	Homo sapiens (human)
cytosol	Tubulin beta-4B chain	Homo sapiens (human)
cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
axonemal microtubule	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta-4B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4B chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4B chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
lamellipodium	Tubulin beta-3 chain	Homo sapiens (human)
filopodium	Tubulin beta-3 chain	Homo sapiens (human)
axon	Tubulin beta-3 chain	Homo sapiens (human)
dendrite	Tubulin beta-3 chain	Homo sapiens (human)
growth cone	Tubulin beta-3 chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-3 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-3 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-3 chain	Homo sapiens (human)
cell periphery	Tubulin beta-3 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-2A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2A chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-2A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-8 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-8 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
meiotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
microtubule	Tubulin beta-8 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-8 chain	Homo sapiens (human)
nucleus	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule	Tubulin alpha-3E chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3E chain	Homo sapiens (human)
condensed chromosome	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1A chain	Homo sapiens (human)
cytosol	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
axonemal microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
plasma membrane	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
neuromuscular junction	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin alpha-1A chain	Homo sapiens (human)
recycling endosome	Tubulin alpha-1A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
vesicle	Tubulin alpha-1C chain	Homo sapiens (human)
membrane raft	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1C chain	Homo sapiens (human)
nucleus	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-6 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-6 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-6 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
nucleus	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2B chain	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-1 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-1 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule	Tubulin beta-1 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay ID	Title	Year	Journal	Article
AID306996	Cytotoxicity against human MCF7 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID337172	Cytotoxicity against human H9 cells
AID307002	Cytotoxicity against human MRC5 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID120695	Compound was evaluated for the antitumor activity against P388 lymphocytic leukemia in mice	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet
AID306994	Cytotoxicity against human 1A9 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID214887	Inhibition of tubulin polymerization interacting at the colchicine binding site.	2000	Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2	Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
AID253355	In vitro cytotoxic activity against human lung carcinoma (A549) tumor cell line	2005	Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1	Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
AID253356	In vitro cytotoxic activity against human ovarian carcinoma (1A9) tumor cell line	2005	Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1	Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
AID306995	Cytotoxicity against human A549 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID214893	Binding affinity towards tubulin protein measured by their ability to displace [3H]colchicine from rat brain at the dose 25 uM	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet
AID214548	In vitro inhibition of mammalian tubulin polymerization by 50%	1998	Journal of medicinal chemistry, May-21, Volume: 41, Issue:11	Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
AID306997	Cytotoxicity against human LNCAP cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID252064	Percentage inhibition of multi drug resistant KB subclone growth expressing P-glycoprotein (KB-V) at 4 ug/mL concentration was determined	2005	Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1	Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
AID211307	In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA control; Inactive	1998	Journal of medicinal chemistry, May-21, Volume: 41, Issue:11	Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
AID306999	Cytotoxicity against human DU145 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID117073	Lethal dose after the intraperitoneal injection in a group of 10 mice	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet
AID253360	In vitro cytotoxic activity against human epidermoid carcinoma of the nasopharynx (KB) tumor cell line	2005	Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1	Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
AID115600	MED(minimum effective dose) against P388 lymphocytic leukemia in mice; this dose produced T/C greater than the threshold value of 125	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet
AID306998	Cytotoxicity against human PC3 cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID337171	Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
AID109716	Antitumor activity against P388 lymphocytic leukemia in mice	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet
AID307001	Cytotoxicity against multi drug-resistant human KBVIN cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID213858	Percentage by which the binding of [3H]colchicine (2.5 uM) to tubulin from calf brain is reduced by 25 uM concentration of compound	1987	Journal of medicinal chemistry, Apr, Volume: 30, Issue:4	A novel synthesis of colchicide and analogues from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent.
AID307000	Cytotoxicity against human KB cells by sulforhodamine B assay	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.
AID241148	Inhibitory concentration against tubulin assembly	2005	Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1	Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (33.33)	18.7374
1990's	1 (16.67)	18.2507
2000's	3 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.89	4	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
glycyrrhetinic acid [no description available]	2.03	1	cyclic terpene ketone; hydroxy monocarboxylic acid; pentacyclic triterpenoid	immunomodulator; plant metabolite
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	1.99	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
thiocholchicine thiocholchicine: RN refers to (S)-isomer	2.89	4
n-methylcolchiceinamide, (s)-isomer [no description available]	1.97	1
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.03	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.03	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	1.99	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
3-demethylthiocolchicine 3-demethylthiocolchicine: RN & structure given in first source; RN not in Chemline 10/85	2.89	4
n-acetylcolchinol o-methyl ether N-acetylcolchinol O-methyl ether: structure given in first source	2	1
thiodemecolcine thiodemecolcine: RN given refers to (S)-isomer; structure given in first source	1.96	1
demecolcine Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.. (-)-demecolcine : A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.	1.96	1	alkaloid; secondary amino compound	antineoplastic agent; microtubule-destabilising agent
colchiceine [no description available]	2.02	1	cyclic ketone
3-desmethylcolchicine 3-desmethylcolchicine: structure	1.97	1
allocolchicine allocolchicine: not allo-isomer of colchicine; structure given in first source; RN given refers to (S)-isomer	2	1

Condition	Relationship Strength	Studies
Experimental Neoplasms [description not available]	1.97	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.96	1
Experimental Leukemia [description not available]	1.96	1

2-demethylthiocolchicine

Description

Cross-References

Synonyms (13)

Protein Targets (16)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (25)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.28

Study Types

2-demethylthiocolchicine

Description

Cross-References

Synonyms (13)

Protein Targets (16)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (25)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.28

Study Types

Related Drugs (15)

Related Conditions (3)