alteichin: unusual phytotoxin from Alternaria eichorniae, fungal pathogen of water hyacinth; doubly hydrated form of 4,9-dihydroxyperylene-3,10-quinone [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 125848 |
| CHEMBL ID | 4452280 |
| CHEBI ID | 2614 |
| SCHEMBL ID | 22837287 |
| MeSH ID | M0128274 |
| Synonym |
|---|
| 88899-62-1 |
| alterperylenol |
| alteichin |
| C10295 , |
| AC1L2PAW , |
| (1s,12ar,12bs)-1,4,9,12a-tetrahydroxy-2,12b-dihydro-1h-perylene-3,10-dione |
| 3,10-perylenedione, 1,2,12a,12b-tetrahydro-1,4,9,12a-tetrahydroxy-, (1alpha,12abeta,12balpha)-(+)- |
| grk18whv7f , |
| unii-grk18whv7f |
| 3,10-perylenedione, 1,2,12a,12b-tetrahydro-1,4,9,12a-tetrahydroxy-, (1s,12ar,12bs)- |
| (+)-alterperylenol |
| 3,10-perylenedione, 1,2,12a,12b-tetrahydro-1,4,9,12a-tetrahydroxy-, (1s-(1.alpha.,12a.beta.,12b.alpha.))- |
| CHEBI:2614 |
| ambotzls-1094 |
| AKOS030213167 |
| DTXSID10237401 |
| CHEMBL4452280 , |
| Q27105736 |
| SCHEMBL22837287 |
| alterperylnol |
| bdbm50595715 |
| Class | Description |
|---|---|
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 (µMol) | 30.0000 | 0.0006 | 2.6948 | 9.4000 | AID1875247 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1875245 | Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Naturally Occurring Partially Reduced Perylenequinones from Fungi. |
| AID1617182 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11 | Alternatone A, an Unusual Perylenequinone-Related Compound from a Soft-Coral-Derived Strain of the Fungus |
| AID1875246 | Cytotoxicity against human SF-268 cells assessed as cell growth inhibition | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Naturally Occurring Partially Reduced Perylenequinones from Fungi. |
| AID1875247 | Inhibition of human telomerase | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Naturally Occurring Partially Reduced Perylenequinones from Fungi. |
| AID1617181 | Antiproliferative activity against human HeLa cells assessed as reduction in cell viability by MTT assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11 | Alternatone A, an Unusual Perylenequinone-Related Compound from a Soft-Coral-Derived Strain of the Fungus |
| AID1617183 | Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability by SRB assay | 2019 | Journal of natural products, 11-22, Volume: 82, Issue:11 | Alternatone A, an Unusual Perylenequinone-Related Compound from a Soft-Coral-Derived Strain of the Fungus |
| AID1875243 | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Naturally Occurring Partially Reduced Perylenequinones from Fungi. |
| AID1875244 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Naturally Occurring Partially Reduced Perylenequinones from Fungi. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.08) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||