| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347414 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID500418 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 20 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500395 | Inhibition of Chk1 phosphorylation in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500441 | Induction of apoptosis in human A2780 cells assessed as active caspase-3 after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504006 | Induction of cell cycle arrest in human SF539 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503818 | Induction of cell cycle arrest in p53 deficient human Jurkat cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500358 | Induction of cell cycle arrest in NHDF expressing p53 gene assessed as accumulation at subG1 phase at 0.1 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503804 | Antiproliferative activity against human MCF7 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288462 | Inhibition of CDK2 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID503808 | Antiproliferative activity against human U2OS cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503782 | Inhibition of PKCbeta | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504003 | Induction of cell cycle arrest in human MCF7 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500423 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 5 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503798 | Antiproliferative activity against p53 deficient human SW480 cells after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503753 | Inhibition of cdk5 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500408 | Inhibition of Chk2 phosphorylation in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503977 | Induction of cell cycle arrest in p53 deficient human SF268 cells assessed as accumulation at subG1 phase at 10 uM after 24 hrs FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411581 | Antiproliferative activity against human HT-29 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID1879133 | Selectivity index, ratio of IC50 for inhibition of PKN1 (unknown origin) to IC50 for inhibition of PKN2 (unknown origin) | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID504023 | Induction of cell cycle arrest in human SF539 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503822 | Induction of cell cycle arrest in human HCT116 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504002 | Induction of cell cycle arrest in p53 deficient human OVCAR8 cells assessed as residual DNA synthesis at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503766 | Inhibition of Ck2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500360 | Inhibition of DNA synthesis in human HeLa cells assessed as Brd-U uptake at 5 uM after 6 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500379 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine41 in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504027 | Induction of cell cycle arrest in NHDF expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503781 | Inhibition of PKAalpha | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500421 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 2 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500449 | Inhibition of Mcm2 phosphorylation at ser40/41 in S-phase of NHDF after 2 to 12 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500364 | Induction of apoptosis in human HeLa cells at 5 uM after 12 hrs in presence of pan-caspase inhibitor Z-VAD | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503786 | Inhibition of TRKA | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500456 | Antitumor activity against DMBA-induced breast cancer in rat after 10 days | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500406 | Inhibition of Chk2 phosphorylation at thr68 in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503817 | Induction of cell cycle arrest in p53 deficient human HCT116-E6 cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500433 | Inhibition of cdk9 human A2780 cells after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504013 | Induction of cell cycle arrest in p53 deficient human HeLa cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503821 | Induction of cell cycle arrest in human MCF7 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504009 | Induction of cell cycle arrest in human PC3 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503752 | Inhibition of cdk1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500388 | Induction of apoptosis in human HeLa cells assessed as appearance of active caspase-3 at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503780 | Inhibition of PDK1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504008 | Induction of cell cycle arrest in human A2780 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504015 | Induction of cell cycle arrest in p53 deficient human COLO205 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500427 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 20 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411583 | Antiproliferative activity against human SW403 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID500420 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 2 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504020 | Induction of cell cycle arrest in human MCF7 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288457 | Inhibition of TNFalpha production in U937 cells | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID503785 | Inhibition of TAO3 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1876137 | Cytotoxicity against 24ST1NLESG cells (unknown origin) | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID503791 | Selectivity ratio of IC50 for Cdk5 to IC50 for cdc7 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500425 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 20 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503994 | Induction of cell cycle arrest in p53 deficient human SF268 cells assessed as residual DNA synthesis at 5 uM after 24 hrs FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500448 | Inhibition of cdc7-mediated Mcm2 phosphorylation at ser40/41 in S-phase of NHDF after 2 to 12 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503788 | Inhibition of VEGFR3 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504011 | Induction of cell cycle arrest in p53 deficient human SF268 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503776 | Inhibition of NIM1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503787 | Inhibition of VEGFR2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500390 | Induction of apoptosis in human HeLa cells assessed as appearance of active caspase-3 at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879136 | Inhibition of MAPKAPK2 (unknown origin) at 1 uM by DiscoverX KINOMEscan assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID500432 | Inhibition of Mcm2 phosphorylation at serine139 in human A2780 cells at 1.2 to 20 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503756 | Inhibition of chk2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503980 | Induction of cell cycle arrest in p53 deficient human SW480 cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500424 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 5 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503993 | Induction of cell cycle arrest in NHDF expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879130 | Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID503792 | Selectivity ratio of IC50 for PLK1 to IC50 for cdc7 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500361 | Inhibition of DNA synthesis in human HeLa cells assessed as Brd-U uptake at 5 uM after 9 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503762 | Inhibition of Aurora-A | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID526193 | Inhibition of Cdc7 | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20
| Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. |
| AID503757 | Inhibition of cdc7 in presence of increasing concentration of ATP | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288465 | Inhibition of IKK2 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID500454 | Antitumor activity against human A2780 cells implanted subcutaneously in nude mouse at 30 mg/kg, iv after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503764 | Inhibition of Cdk7 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503812 | Induction of cell cycle arrest in p53 deficient human SF268 cells assessed as accumulation at subG1 phase at 5 uM after 24 hrs FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500363 | Induction of apoptosis in human HeLa cells at 5 uM after 24 hrs in presence of pan-caspase inhibitor Z-VAD | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288460 | Inhibition of MNK1 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID500376 | Inhibition of cdc7-mediated Mcm2 phosphorylation at serine53 in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500429 | Inhibition of cdc7-mediated Mcm2 phosphorylation at serine40/41 in human A2780 cells after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503799 | Antiproliferative activity against p53 deficient human COLO205 cells after 72 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503797 | Antiproliferative activity against p53 deficient human HeLa cells after 72 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503772 | Inhibition of c-Kit | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503806 | Antiproliferative activity against human HCT15 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411582 | Antiproliferative activity against human L363 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503768 | Inhibition of ERK2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500443 | Induction of cell cycle arrest in NHDF assessed as accumulation at subG1 phase at 5 uM after 24hrs by propidium-iodine staining based FACS analysis in presence of p53 specific siRNA | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503825 | Induction of cell cycle arrest in human U2OS cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503990 | Induction of cell cycle arrest in human U2OS cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500375 | Inhibition of cdc7-mediated Mcm2 phosphorylation at serine53 in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503801 | Antiproliferative activity against p53 deficient human Jurkat cells after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500442 | Induction of cell cycle arrest in NHDF assessed as accumulation at subG1 phase at 5 uM after 24hrs by propidium-iodine staining based FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503778 | Inhibition of PAK4 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500446 | Prevention of nocodazole induced mitotic arrest in NHDF after 1 hr by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500378 | Inhibition of cdc7-mediated Mcm2 phosphorylation at serine53 in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879129 | Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysis | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID500380 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine41 in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500391 | Induction of apoptosis in human HeLa cells assessed as appearance of PARP at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503989 | Induction of cell cycle arrest in human SF539 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500370 | Inhibition of cdc7-mediated Mcm2 phosphorylation in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503974 | Induction of cell cycle arrest in human A2780 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500447 | Effect on p53 accumulation in S-phase cells of NHDF after 2 to 12 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504014 | Induction of cell cycle arrest in p53 deficient human SW480 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503981 | Induction of cell cycle arrest in p53 deficient human COLO205 cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID412042 | Antitumor activity against DMBA-induced mammary carcinoma in CD OFA rat assessed as duration of tumor stabilization maintenance at 20 mg/kg, po administered for 10 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503767 | Inhibition of EGFR-1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500409 | Inhibition of Chk2 phosphorylation in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500401 | Inhibition of Chk1 phosphorylation at serine345 in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID509584 | Inhibition of MNK2 | 2010 | Journal of medicinal chemistry, Sep-23, Volume: 53, Issue:18
| Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. |
| AID503992 | Induction of cell cycle arrest in human PC3 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504017 | Induction of cell cycle arrest in p53 deficient human Jurkat cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288458 | Inhibition of MK3 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID411540 | Antiproliferative activity against human A2780 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID288461 | Inhibition of MSK1 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID503979 | Induction of cell cycle arrest in p53 deficient human HeLa cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504007 | Induction of cell cycle arrest in human U2OS cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500465 | Inhibition of cdk-mediated NPM phosphorylation at thr199 in human A2780 cells at 10 uM | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503770 | Inhibition of IKK2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503820 | Induction of cell cycle arrest in p53 deficient human OVCAR8 cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500426 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 20 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500404 | Inhibition of Chk2 phosphorylation at thr68 in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500455 | Antitumor activity against human MX1 cells implanted subcutaneously in nude mouse at 30 mg/kg, po after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503995 | Induction of cell cycle arrest in p53 deficient human K562 cells assessed as residual DNA synthesis at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500461 | Clearance in SCID mouse carrying human HL60 cells at 20 mg/kg or 30 mg/kg, iv after 10 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504005 | Induction of cell cycle arrest in human HCT15 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503793 | Selectivity ratio of IC50 for CHK2 to IC50 for cdc7 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500417 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 20 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500422 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 5 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503975 | Induction of cell cycle arrest in human PC3 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500643 | Inhibition of DNA replication in human HeLa cells assessed as increase in replication fork speed per min at 2 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1894068 | Inhibition of CDC7 (unknown origin) | 2021 | Journal of medicinal chemistry, 02-11, Volume: 64, Issue:3
| Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. |
| AID503751 | Inhibition of cdk2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503759 | Inhibition of c-Abl | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504012 | Induction of cell cycle arrest in p53 deficient human K562 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503748 | Inhibition of cdc7 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1875950 | Inhibition of CDK9 (unknown origin) | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID504022 | Induction of cell cycle arrest in human HCT15 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879134 | Inhibition of ROCK1 (unknown origin) at 1 uM by DiscoverX KINOMEscan assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID503794 | Antiproliferative activity against human NCI60 cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500385 | Induction of apoptosis in human HeLa cells assessed as appearance of gamma-H2AX at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503796 | Antiproliferative activity against p53 deficient human K562 cells after 72 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503779 | Inhibition of PDGFR | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879135 | Inhibition of ROCK2 (unknown origin) at 1 uM by DiscoverX KINOMEscan assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID288456 | Inhibition of MK2 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID503749 | Inhibition of cdk9 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503816 | Induction of cell cycle arrest in p53 deficient human COLO205 cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503978 | Induction of cell cycle arrest in p53 deficient human K562 cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503775 | Inhibition of Nek6 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503982 | Induction of cell cycle arrest in p53 deficient human HCT116-E6 cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500434 | Inhibition of cdk-mediated NPM phosphorylation at thr199 in human A2780 cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503999 | Induction of cell cycle arrest in p53 deficient human HCT116-E6 cells assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID509582 | Inhibition of MNK1 | 2010 | Journal of medicinal chemistry, Sep-23, Volume: 53, Issue:18
| Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. |
| AID500368 | Inhibition of cdc7-mediated Mcm2 phosphorylation in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503823 | Induction of cell cycle arrest in human HCT15 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500399 | Inhibition of Chk1 phosphorylation at serine345 in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879137 | Inhibition of NanoLuc-PKN2 (ser646-cys984)(unknown origin) expressed in HEK293 cells by cell-based NanoBRET target engagement assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID500393 | Induction of apoptosis in human HeLa cells assessed as appearance of PARP at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500451 | Antitumor activity against human HL60 cells injected subcutaneously in SCID mouse at 30 mg/kg, iv after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500445 | Induction of cell cycle arrest in thymidine deficient NHDF assessed as DNA synthesis in S-phase at 5 uM after 16hrs FACS analysis in presence of serum | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288478 | Inhibition of MSK2 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID503984 | Induction of cell cycle arrest in p53 deficient human A2780/E6 cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504019 | Induction of cell cycle arrest in p53 deficient human OVCAR8 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411580 | Antiproliferative activity against human HCT16 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503997 | Induction of cell cycle arrest in p53 deficient human SW480 cells assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411585 | Antiproliferative activity against human NCI-H929 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503774 | Inhibition of c-Met | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503771 | Inhibition of IR | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503800 | Antiproliferative activity against p53 deficient human HCT116/E6 cells after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503807 | Antiproliferative activity against human SF539 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500386 | Induction of apoptosis in human HeLa cells assessed as appearance of gamma-H2AX at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500383 | Induction of apoptosis in human HeLa cells assessed as appearance of gamma-H2AX at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503754 | Inhibition of Mk2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504010 | Induction of cell cycle arrest in NHDF expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503976 | Induction of cell cycle arrest in NHDF expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503765 | Inhibition of chk1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504025 | Induction of cell cycle arrest in human A2780 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500467 | Inhibition of cdk4-mediated Rb phosphorylation at ser807/811 in human A2780 cells at 10 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503809 | Antiproliferative activity against human A2780 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500466 | Inhibition of cdk-mediated Rb phosphorylation at thr821 in human A2780 cells at 10 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879132 | Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID503983 | Induction of cell cycle arrest in p53 deficient human Jurkat cells assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503750 | Inhibition of GSK3-beta | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503811 | Antiproliferative activity against NHDF expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500419 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 20 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500387 | Induction of apoptosis in human HeLa cells assessed as appearance of active caspase-3 at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500382 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine41 in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500444 | Induction of cell cycle arrest in thymidine deficient NHDF assessed as DNA synthesis in S-phase at 5 uM after 2hrs FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503783 | Inhibition of Ret | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500450 | Antitumor activity against human HL60 cells injected subcutaneously in SCID mouse at 20 mg/kg, iv after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503824 | Induction of cell cycle arrest in human SF539 cells expressing p53 gene assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500459 | AUC in rat carrying DMBA-induced mammary carcinoma at 10 mg/kg, iv after 10 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504000 | Induction of cell cycle arrest in p53 deficient human Jurkat cells assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500416 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 5 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503815 | Induction of cell cycle arrest in p53 deficient human SW480 cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500359 | Inhibition of DNA synthesis in human HeLa cells assessed as Brd-U uptake at 5 uM by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500397 | Inhibition of Chk1 phosphorylation in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500410 | Inhibition of Chk2 phosphorylation in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500366 | Induction of apoptosis in NHDF at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500367 | Inhibition of cdc7-mediated Mcm2 phosphorylation in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879131 | Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysis | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID500430 | Inhibition of Mcm2 phosphorylation at serine41 in human A2780 cells at 1.2 to 20 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503755 | Inhibition of plk1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500362 | Inhibition of DNA synthesis in human HeLa cells assessed as Brd-U uptake at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500405 | Inhibition of Chk2 phosphorylation at thr68 in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504026 | Induction of cell cycle arrest in human PC3 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503814 | Induction of cell cycle arrest in p53 deficient human HeLa cells assessed as assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500377 | Inhibition of cdc7-mediated Mcm2 phosphorylation at serine53 in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500411 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 2 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500384 | Induction of apoptosis in human HeLa cells assessed as appearance of gamma-H2AX at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503769 | Inhibition of FGFR1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500398 | Inhibition of Chk1 phosphorylation in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500402 | Inhibition of Chk1 phosphorylation at serine345 in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500400 | Inhibition of Chk1 phosphorylation at serine345 in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1876136 | Antiviral activity against HSV-1-induced necrosis | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID411541 | Apparent permeability by PAMPA method | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503760 | Inhibition of AKT1 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411584 | Antiproliferative activity against human SW48 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID500389 | Induction of apoptosis in human HeLa cells assessed as appearance of active caspase-3 at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411578 | Antiproliferative activity against human MCF7 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID411586 | Antiproliferative activity against human OPM2 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503985 | Induction of cell cycle arrest in p53 deficient human OVCAR8 cells assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503758 | Inhibition of cdc7 in presence of increasing concentration of substrate | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503777 | Inhibition of P38beta | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503991 | Induction of cell cycle arrest in human A2780 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503773 | Inhibition of LCK | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503987 | Induction of cell cycle arrest in human HCT116 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503805 | Antiproliferative activity against human HCT116 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504018 | Induction of cell cycle arrest in p53 deficient human A2780/E6 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504021 | Induction of cell cycle arrest in human HCT116 cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500413 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 2 uM after 6 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503784 | Inhibition of STLK2 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500437 | Inhibition of RNA polymerase 2 in human A2780 cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID312996 | Inhibition of human Cdc7 | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. |
| AID412041 | Antitumor activity against human A2780 cells xenografted in CDI nu/nu mouse assessed as tumor growth inhibition at 60 mg/kg, po administered for 10 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID500414 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 5 uM after 2 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500435 | Inhibition of cdk-mediated Rb phosphorylation at thr821 in human A2780 cells after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504001 | Induction of cell cycle arrest in p53 deficient human A2780/E6 cells assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503803 | Antiproliferative activity against p53 deficient human OVCAR8 cells after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503988 | Induction of cell cycle arrest in human HCT15 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504016 | Induction of cell cycle arrest in p53 deficient human HCT116-E6 cells assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503813 | Induction of cell cycle arrest in p53 deficient human K562 cells assessed as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1879139 | Toxicity in human HeLa cells assessed as cell viability at 50 uM incubated for 24 hrs by MTT assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. |
| AID500452 | Antitumor activity against human HCT116 cells implanted subcutaneously in nude mouse at 20 mg/kg, iv after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500381 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine41 in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500371 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine40/41 in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500462 | Inhibition of cdc7-mediated Mcm2 phosphorylation at ser40/41 in human HCT116 cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503802 | Antiproliferative activity against p53 deficient human A2780/E6 cells after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503819 | Induction of cell cycle arrest in p53 deficient human A2780/E6 cells as accumulation at subG1 phase at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500412 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 2 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1875978 | Antiviral activity against HSV-1 KOS strain infected in 1 hr pretreated mouse L929 cells assessed as cell viability by cell titre-glo luminescent kit method | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID500407 | Inhibition of Chk2 phosphorylation in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411542 | Inhibition of CDK9 | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503789 | Inhibition of ZAP70 | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503795 | Antiproliferative activity against p53 deficient human SF268 cells after 72 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411587 | Antiproliferative activity against human NHDF cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID500372 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine40/41 in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500463 | Inhibition of cdc7-mediated Rb phosphorylation at ser807/811 in human HCT116 cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504004 | Induction of cell cycle arrest in human HCT116 cells expressing p53 gene assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411579 | Antiproliferative activity against human COLO205 cells after 72 hrs by luciferase based assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID503998 | Induction of cell cycle arrest in p53 deficient human COLO205 cells assessed as residual DNA synthesis at 5 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500365 | Induction of apoptosis in NHDF at 5 uM after 12 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID288459 | Inhibition of MK5 | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID500403 | Inhibition of Chk2 phosphorylation at thr68 in human HeLa cells at 5 uM after 3 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID312997 | Antiproliferative activity against human A2780 cells after 72 hrs | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. |
| AID503986 | Induction of cell cycle arrest in human MCF7 cells expressing p53 gene assessed as accumulation at subG1 phase at 10 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500369 | Inhibition of cdc7-mediated Mcm2 phosphorylation in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503996 | Induction of cell cycle arrest in p53 deficient human HeLa cells assessed as residual DNA synthesis at 5 uM after 24hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500453 | Antitumor activity against human HCT116 cells implanted subcutaneously in nude mouse at 30 mg/kg, iv after 5 days bid | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500458 | AUC in SCID mouse carrying human HL60 cells at 30 mg/kg, iv after 10 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500415 | Inhibition of DNA replication in human HeLa cells assessed as interorigin distance between homogenous DNA fibers at 5 uM after 4 hrs by immunofluorescence assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503790 | Selectivity ratio of IC50 for MK2 to IC50 for cdc7 in | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500373 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine40/41 in human HeLa cells at 5 uM after 9 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500396 | Inhibition of Chk1 phosphorylation in human HeLa cells at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID411539 | Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID500431 | Inhibition of Mcm2 phosphorylation at serine13 in human A2780 cells at 1.2 to 20 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500460 | Clearance in rat carrying DMBA-induced mammary carcinoma at 10 mg/kg, iv after 10 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500428 | Inhibition of Mcm2 phosphorylation in human A2780 cells after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500394 | Induction of apoptosis in human HeLa cells assessed as appearance of PARP at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503810 | Antiproliferative activity against human PC3 cells expressing p53 gene after 72 hrs by proliferative assay | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500392 | Induction of apoptosis in human HeLa cells assessed as appearance of PARP at 5 uM after 6 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1875976 | Inhibition of Cdc7 (unknown origin) | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2
| Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID500457 | AUC in SCID mouse carrying human HL60 cells at 20 mg/kg, iv after 10 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID504024 | Induction of cell cycle arrest in human U2OS cells expressing p53 gene assessed as residual DNA synthesis at 10 uM after 24 hrs by FACS analysis | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503763 | Inhibition of Aurora-B | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500464 | Antitumor activity against human HCT116 cells assessed as appearance of Ki67 positive cells | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID503761 | Inhibition of Alk | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID500374 | Inhibition of cdc7-mediated Mcm2 phosphorylation at sreine40/41 in human HeLa cells at 5 uM after 24 hrs | 2008 | Nature chemical biology, Jun, Volume: 4, Issue:6
| A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. |
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID493040 | Navigating the Kinome | 2011 | Nature chemical biology, Apr, Volume: 7, Issue:4
| Navigating the kinome. |
| AID1798799 | In Vitro Kinase Assay from Article 10.1021/jm800977q: \\First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.\\ | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. |
| AID1799071 | MK-2 IC50 Value Determination from Article 10.1021/jm0611004: \\Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).\\ | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID1799072 | Kinase Selectivity Assay from Article 10.1021/jm0611004: \\Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).\\ | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID1798802 | In Vitro Kinase Assay from Article 10.1021/jm700956r: \\Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.\\ | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. |
| AID1345339 | Human ribosomal protein S6 kinase A4 (MSK subfamily) | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| AID1345737 | Human mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK subfamily) | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |