| ID Source | ID |
|---|---|
| PubMed CID | 163701 |
| CHEMBL ID | 1237129 |
| CHEBI ID | 31854 |
| SCHEMBL ID | 161558 |
| MeSH ID | M0481961 |
| Synonym |
|---|
| savella |
| toledomin |
| midalcipran hydrochloride |
| dalcipran |
| ixel |
| cis-(+-)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride |
| f 2207 |
| cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, monohydrochloride, (1r,2s)-rel- |
| 1-phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane hydrochloride |
| cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, monohydrochloride, cis-(+-)- |
| MLS001424149 |
| MLS000758229 |
| smr000449266 |
| milnacipran hydrochloride (jan/usan) |
| D01107 |
| savella (tn) |
| toledomin (tn) |
| 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hcl |
| rac-milnacipran hydrochloride |
| tox21_112641 |
| cas-101152-94-7 |
| dtxcid2026785 |
| dtxsid4046785 , |
| cis-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide hydrochloride |
| (1rs,2sr)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide hydrochloride |
| milnacipran hydrochloride [usan] |
| z-2 aminomethyl-1-phenyl-n,n-diethylcyclopropane-carboxamide hydrochloride |
| milnacipran hcl |
| nsc 759806 |
| unii-rnz43o5ww5 |
| rnz43o5ww5 , |
| AKOS015950801 |
| CCG-101034 |
| 175131-61-0 |
| (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide hydrochloride |
| (1r-cis)-milnacipran hydrochloride |
| (1r,2s)-rel-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride |
| CHEMBL1237129 |
| S3140 |
| milnacipran hydrochloride [who-dd] |
| milnacipran hydrochloride [mi] |
| milnacipran hydrochloride [mart.] |
| milnacipran hydrochloride [orange book] |
| milnacipran hydrochloride [usp-rs] |
| milnacipran hydrochloride [vandf] |
| milnacipran hydrochloride [jan] |
| milnacipran (hydrochloride) |
| CS-2010 |
| HY-B0168A |
| NC00284 |
| SCHEMBL161558 |
| KS-1274 |
| milnacipran hydrochloride, >=98% (hplc), solid |
| CHEBI:31854 |
| J-011063 |
| f2207 |
| SW197664-2 |
| BCP05817 |
| AMY22199 |
| cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, hydrochloride (1:1), (1r,2s)-rel- |
| 1 phenyl 1 diethylaminocarbonyl 2 aminomethylcyclopropane hcl |
| Q27288221 |
| milnacipran hydrochloride (mart.) |
| cis-2-aminomethyl-n,n-diethyl-1-phenylcyclopropane-carboxamide monohydrochloride |
| milnacipran hydrochloride (usp-rs) |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Class | Description |
|---|---|
| acetamides | Compounds with the general formula RNHC(=O)CH3. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 39.8107 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.9521 | 0.0002 | 29.3054 | 16,493.5996 | AID743075 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 14.1254 | 0.0398 | 16.7842 | 39.8107 | AID1454 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 (µMol) | 0.0500 | 0.0008 | 1.5416 | 20.0000 | AID1745860 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| cell surface | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| membrane | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| neuronal cell body membrane | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| presynaptic membrane | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| plasma membrane | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| axon | Sodium-dependent noradrenaline transporter | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID222978 | Antagonism of tetrabenazine-induced ptosis in mice was evaluated after oral administration | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. |
| AID1912479 | Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells (PubChem AID: 174586 | 2021 | Scientific reports, 06-10, Volume: 11, Issue:1 | Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors. |
| AID223128 | Ability to kill 50% of the animals (administered orally), after sublethal dose of yohimbine (25 mg/Kg) when given subcutaneously. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. |
| AID224549 | % increase of the diameter of the test pupil (% mydriasis) in comparison with that of the control pupil. | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. |
| AID221731 | Ability to kill 50% of the animals after 24h, when administered perorally | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. |
| AID223123 | Potentiation of 5-hydroxytryptophan-induced head twitch in mice after oral administration | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||