| Assay ID | Title | Year | Journal | Article |
|---|
| AID10110 | Half life following administration of 70 nM in canine whole blood (dose exceeding platelet binding capacity) | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID225754 | Inhibition of platelet aggregation after administration of 10 ug/kg iv to dogs at 8 hr | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. |
| AID92238 | Inhibition of aggregation of human gel-filtered platelets was measured by light transmittance method. | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID221916 | Percent inhibition of gel filtered platelet aggregation induced by ADP | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. |
| AID233840 | Selectivity as determined by the ratio of KDs, resting receptor over activated receptor | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors. |
| AID73139 | Displacement of L-736,622 from purified resting Fibrinogen Receptor | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID73005 | Displacement of [125I]L-692884 from purified Fibrinogen Receptor activated by coating onto yttrium silicate | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID225753 | Inhibition of platelet aggregation after administration of 0.1 ug/kg at 24 hr | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. |
| AID60370 | Ex vivo inhibition of platelet aggregation at 24 hr after the oral administration of 100 mg/kg in dogs | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID160070 | Inhibition of ADP induced platelet aggregation after administration of 10 ug/kg by gastric lavage | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID84829 | Inhibition of human umbilical vein endothelial cells (HUVEC) attachment to vitronectin (VN) | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID220879 | Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity assay fluomicrospheres. | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors. |
| AID222789 | Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C. | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors. |
| AID220877 | Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets. | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors. |
| AID84828 | Inhibition of human umbilical vein endothelial cells (HUVEC) attachment to fibronectin | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID84827 | Inhibition of human umbilical vein endothelial cells (HUVEC) attachment to fibrinogen (FG) | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID160072 | Inhibition of platelet aggregation at 1 min by intravenous administration at the dose of 10 ug/kg | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
| AID225755 | Inhibition of platelet aggregation after administration of 10 ug/kg iv to dogs within 1 min | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |