| Assay ID | Title | Year | Journal | Article |
|---|
| AID10435 | Biological half-life measured in plasma of rat; 9-16 | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID195369 | Compound was measured for in vitro efficacy in blocking vitronectin-induced migration of rat aortic smooth muscle cells (RASMC) | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID82356 | HEK cell adhesion mediated by alpha v beta 3 integrin | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID29070 | Half life period in rat | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID82222 | Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated plates | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists. |
| AID217446 | Affinity for vitronectin receptor, integrin alphaV-beta3 | 1997 | Journal of medicinal chemistry, Jul-18, Volume: 40, Issue:15
| Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists. |
| AID220754 | Affinity for alphaIIb-beta3 receptor | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists. |
| AID229243 | Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists. |
| AID82223 | Inhibition of HEK 293 cell adhesion to vitronectin by alpha V beta 3 | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| AID220890 | Binding affinity for alpha IIb beta3 integrin | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| AID11811 | Maximum plasma concentration of compound was measured in rat | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID223068 | Antagonistic activity for human vitronectin receptor (alphaV-beta3) from platelets | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID11191 | Plasma clearance was measured in rat | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID73150 | Affinity for platelet fibrinogen receptor, integrin alpha IIb/beta3 | 1997 | Journal of medicinal chemistry, Jul-18, Volume: 40, Issue:15
| Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists. |
| AID220617 | Inhibition of binding to alphaV-beta3 integrin | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21
| Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design. |
| AID29433 | Oral bioavailability in rat | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID217316 | Binding affinity towards human Vitronectin receptor. | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics. |
| AID13161 | Bioavailability was measured in rat after oral administration; 3-7 | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID27901 | Plasma clearance in rat | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID82221 | Antagonistic activity was measured by the adhesion of HEK 293 cells transfected with human alphaV-beta3 to vitronectin-coated plates | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model. |
| AID220888 | Binding affinity towards human alpha IIb beta-3 integrin by [3H]-RGD peptide displacement. | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics. |
| AID13658 | Oral bioavailability in rat | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| AID217314 | Binding affinity for Vitronectin receptor (alpha V beta 3) | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID220880 | Binding affinity for alpha IIb beta-3 integrin | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. |
| AID12685 | Half-life was determined | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| AID217437 | Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3) | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| AID13454 | Plasma clearance of the compound | 1999 | Bioorganic & medicinal chemistry letters, Jul-05, Volume: 9, Issue:13
| Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |