AID1613402 | Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 0.05 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.65%) | | | |
AID1064325 | Induction of apoptosis in human Jurkat cells assessed as active caspase 3 expression at 15 nM by FITC-conjugated flow cytometric analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID144649 | The compound was tested for the concentration for 50% growth inhibition of NCI 60 cell line human tumor screen. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1555137 | Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 1 uM measured after 10 mins by beckman scintillation counting method relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
| Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. |
AID1064344 | Induction of apoptosis in human Jurkat cells assessed as decrease in sub-G1 phase cells at 15 nM after 24 to 48 hrs by propidium iodide staining-based flow cytometric analysis in presence of pancaspase peptide inhibitor z-VAD-fmk | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1338009 | Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1565963 | Antitumour activity against human A549 cells xenografted in BALB/c nude mouse assessed as tumour weight at 30 mg/kg, ip administered every other day measured at day 26 by electronic caliper method (Rvb = 1.894 g) | | | |
AID247220 | Growth inhibition against human pharynx FADU cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID657882 | Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID1320430 | Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID1315234 | Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1437255 | Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay | 2017 | Bioorganic & medicinal chemistry, 03-01, Volume: 25, Issue:5
| Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents. |
AID1858333 | Antiangiogenic activity in chicken fertilized egg chorioallantoic membrane assessed as inhibition of neovascularization at 50 uM measured after 48 hrs by microscopic analysis relative to control | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9
| New β-carboline derivatives containing imidazolium as potential VEGFR2 inhibitors: synthesis, X-ray structure, antiproliferative evaluations, and molecular modeling. |
AID1320436 | Disruption of interphase microtubule in HUVEC assessed as change in cell shape and morphology at 250 nM preincubated for 30 mins followed by compound washout measured after 60 mins by DAPI staining-based immunofluorescence assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID767876 | Cytotoxicity against human NCI-H460 cells by SRB assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9
| Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. |
AID1320447 | Induction of necrosis in human SW1222 cells xenografted in SCID mouse at 0.227 mmol/kg administered as single dose measured after 24 hrs by hematoxylin/eosin staining-based microscopic method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID201133 | The compound was tested for the concentration to inhibit 50% of CNS SF-295 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1183700 | Antitumor activity against mouse BNL 1ME A.7R.1 cells xenografted in Balb/c mouse model of syngeneic murine hepatocellular carcinoma assessed as reduction tumor growth at 5 mg/kg, ip | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15
| Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles. |
AID1320446 | Induction of HUVEC monolayer permeability assessed as increase in passage of FITC-dextran through cell monolayer at 50 nM preincubated for 30 mins followed by compound washout and addition of FITC-dextran for 30 mins by fluorescence assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID83950 | Cytotoxicity evaluated against colon cancer cell line (HT-29) | 2003 | Bioorganic & medicinal chemistry letters, May-05, Volume: 13, Issue:9
| Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. |
AID1315227 | Antimitotic activity in sea urchin Paracentrotus lividus L embryo assessed as induction of cleavage alteration | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1411801 | Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID421857 | Antitumor activity against human BxPC3 cells by sulforhodamine B assay | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3
| Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. |
AID1690540 | Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. |
AID1064343 | Induction of apoptosis in human Jurkat/A4 cells assessed as decrease in sub-G1 phase cells at 150 nM after 24 to 48 hrs by propidium iodide staining-based flow cytometric analysis in presence of pancaspase peptide inhibitor z-VAD-fmk | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1555138 | Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 5 uM measured after 10 mins by beckman scintillation counting method relative to control | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
| Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. |
AID1565964 | Antitumour activity against human A549 cells xenografted in BALB/c nude mouse assessed as tumour growth inhibition at 30 mg/kg, ip administered every other day measured at day 26 by electronic caliper method relative to control | | | |
AID150376 | The compound was tested for the concentration to inhibit 50% of leukemia P388 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1613389 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | | | |
AID657907 | Inhibition of purified tubulin assembly after 20 mins | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID1197838 | Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. |
AID403646 | Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10
| Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). |
AID421865 | Aqueous solubility of compound in water | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3
| Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. |
AID403644 | Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10
| Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). |
AID403645 | Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10
| Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). |
AID1064358 | Cell cycle arrest in human Jurkat cells assessed as accumulation at sub-G1 phase at 15 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 12.2%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1315231 | Growth inhibition of human A375 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID247255 | Growth inhibition against human neuroblastoma cell line (SK-N-SH) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID376520 | Cytotoxicity against mouse P388 cells | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7
| Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane. |
AID1064350 | Induction of apoptosis in human Jurkat cells assessed as small cell fragments with unequally segregated chromosomes enclosed by cell membrane after 48 hrs by May-Grunwald-Giemsa staining-based microscopic analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID550210 | Antimitotic activity against Paracentrotus lividus embryo assessed as cleavage arrest after 2.5 to 6 hrs post fertilization by sea urchin embryo assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11
| Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes. |
AID106518 | In vitro cytotoxicity evaluated in mouse heart endotheliaoma cell (MHEC5-T) after incubation of the cells for 1 hr | 2003 | Bioorganic & medicinal chemistry letters, May-05, Volume: 13, Issue:9
| Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. |
AID1608986 | Antitumour activity against mouse E0771 cells allografted in C57BL/6 mouse assessed as reduction in tumor mass at 30 mg/kg, ip administrated every other day by caliper method | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors. |
AID1315228 | Antimitotic activity against sea urchin Paracentrotus lividus L embryo assessed as induction of cleavage arrest | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1382776 | Antiproliferative activity against human HeLa cells after 3 days by coulter counting method | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. |
AID1064319 | Induction of apoptosis in human Jurkat/A4 cells assessed as active caspase 3 expression at 150 nM after 24 hrs by FITC-conjugated flow cytometric analysis (Rvb = 1.1%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1055625 | Cytotoxicity against human DU145 cells after 48 hrs by SRB assay | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
| Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents. |
AID247232 | Growth inhibition against human prostate cell line (DU-145) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID1055626 | Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
| Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents. |
AID247231 | Growth inhibition against human lung-NSC NCI-H460 cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID1064363 | Cell cycle arrest in human Jurkat/A4 cells assessed as increase in accumulation at G2/M phase at 150 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1338014 | Antiproliferative activity against human MDA-MB-DYT2 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1064337 | Induction of apoptosis in human Jurkat/A4 cells assessed as caspase 9 activation at 150 nM after 24 to 48 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID88795 | Evaluated for growth inhibition (anticancer activity) in Human CNS cancer SF-295 cell line | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
AID1059956 | Antitumor activity against human MNNG-HOS cells xenografted in Balb/c-nu mouse assessed as reduction in tumor weight at 50 mg/kg, ip administered once every 3 days for 9 days measured after day 18 | 2013 | Journal of medicinal chemistry, Nov-27, Volume: 56, Issue:22
| Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. |
AID1651888 | Induction of vascular damage in mouse 4T1 cells harboring firefly luciferase reporter gene implanted BALB/C mouse assessed as reduction in light emission at 120 mg/kg, ip measured after 4 hrs by Bioluminescence imaging analysis | 2020 | Journal of natural products, 04-24, Volume: 83, Issue:4
| Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia. |
AID1613393 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay | | | |
AID1064351 | Induction of apoptosis in human Jurkat cells assessed as micronuclei formation after 48 hrs by May-Grunwald-Giemsa staining-based microscopic analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID657881 | Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID737075 | Antitumor activity against mouse BNL 1ME A.7R.1 cells xenografted in Balb/c mouse assessed as reduction in tumor growth at 5 mg/kg, ip QD for 7 days | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6
| Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. |
AID1382777 | Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. |
AID481679 | Antimitotic activity against Paracentrotus lividus embryo assessed as cleavage arrest after 10 to 15 mins fertilization 45 to 60 mins before first mitotic cycle completeion | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. |
AID481678 | Antiproliferative activity against Paracentrotus lividus embryo assessed as cleavage alteration after 10 to 15 mins fertilization 45 to 60 mins before first mitotic cycle completeion | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. |
AID1651889 | Induction of vascular damage in mouse 4T1 cells harboring firefly luciferase reporter gene implanted BALB/C mouse assessed as reduction in light emission at 120 mg/kg, ip measured up to 72 hrs by Bioluminescence imaging analysis | 2020 | Journal of natural products, 04-24, Volume: 83, Issue:4
| Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia. |
AID421856 | In vivo antitumor activity against mouse P388 cells | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3
| Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. |
AID1064322 | Induction of apoptosis in human Jurkat cells assessed as active caspase 3 expression at 15 nM after 48 hrs by FITC-conjugated flow cytometric analysis (Rvb = 3.3%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1338011 | Antiproliferative activity against human MDA-MB-435 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1858331 | Antiangiogenic activity in chicken fertilized egg chorioallantoic membrane assessed as inhibition of neovascularization at 0.5 uM measured after 48 hrs by microscopic analysis relative to control | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9
| New β-carboline derivatives containing imidazolium as potential VEGFR2 inhibitors: synthesis, X-ray structure, antiproliferative evaluations, and molecular modeling. |
AID1411797 | Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1613401 | Induction of apoptosis in human HeLa cells assessed as viable cells at 0.05 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 92.8%) | | | |
AID1538742 | Antitumour activity against mouse B16-BL6 cells allografted in C57BL/6 mouse assessed as reduction in tumor mass at 30 mg/kg, ip administrated every other day relative to control | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones. |
AID1411802 | Inhibition of pig brain tubulin polymerization by spectrophotometric analysis | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1315236 | Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID550209 | Antimitotic activity against Paracentrotus lividus embryo assessed as cleavage alteration after 2.5 to 6 hrs post fertilization by sea urchin embryo assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11
| Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes. |
AID443467 | Cytotoxicity against human HeLa cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24
| Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. |
AID1055627 | Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
| Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents. |
AID147801 | The compound was tested for the concentration to inhibit 50% of ovarian OVCAR cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1064366 | Cell cycle arrest in human Jurkat cells assessed as decrease in accumulation at G0/G1 phase at 15 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID657879 | Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID1613391 | Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay | | | |
AID1595721 | Antitumor activity against mouse H22 cells allografted in ICR mouse assessed as reduction in tumour weight at 20 mg/kg, iv administered once per day for 21 days relative to control | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents. |
AID1064367 | Cell cycle arrest in human Jurkat cells assessed as increase in accumulation at G2/M phase at 15 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1613463 | Antitumor activity against human HeLa cells xenografted in nude mouse assessed as tumor weight at 10 mg/kg, iv administered every other day up to 20 days (Rvb = 1.014 +/- 0.116g) | | | |
AID1458857 | Antitumor activity against human A549 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 30 mg/kg, ip | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
AID1690539 | Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. |
AID247233 | Growth inhibition against human thyroid cell line( SW 1736) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID330416 | Cytotoxicity against mouse MHEC5-T cells after 5 days by MTT assay | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. |
AID1338002 | Antiproliferative activity against human NCI60 cells measured after 48 hrs by SRB assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1338007 | Antiproliferative activity against human TOV112D cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID421862 | Antitumor activity against human DU145 cells by sulforhodamine B assay | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3
| Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. |
AID1197840 | Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. |
AID550211 | Antimitotic activity against Paracentrotus lividus embryo assessed as embryo spinning after 0.5 to 20 hrs post dose by sea urchin embryo assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11
| Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes. |
AID512076 | Antitumor activity against mouse 3LL cells transplanted in to BALB/c mouse assessed as tumor growth inhibition at 100 mg/kg, ip qd for 2 days | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
AID403641 | Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay | 2005 | Journal of natural products, Oct, Volume: 68, Issue:10
| Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). |
AID1555132 | Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
| Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. |
AID1064329 | Induction of apoptosis in human Jurkat cells assessed as Bcl-2 expression at 15 nM after 24 to 48 hrs Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID330414 | Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 100 mg/kg, ip after 24 hrs | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. |
AID1550784 | Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. |
AID512075 | Antitumor activity against mouse 3LL cells transplanted in to BALB/c mouse assessed as tumor growth inhibition at 50 mg/kg, ip qd for 2 days | 2010 | Journal of medicinal chemistry, Sep-09, Volume: 53, Issue:17
| Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. |
AID1437254 | Inhibition of porcine tubulin assembly measured for 30 mins by UV/visible spectrophotometric method | 2017 | Bioorganic & medicinal chemistry, 03-01, Volume: 25, Issue:5
| Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents. |
AID1612655 | Antitumor activity against human H22 cells xenografted in ICR mouse assessed as reduction in tumor weight at 20 mg/kg/day, iv for 21 days relative to control | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. |
AID1613403 | Induction of apoptosis in human HeLa cells assessed as late apoptotic cells at 0.05 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.51%) | | | |
AID1858332 | Antiangiogenic activity in chicken fertilized egg chorioallantoic membrane assessed as inhibition of neovascularization at 5 uM measured after 48 hrs by microscopic analysis relative to control | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9
| New β-carboline derivatives containing imidazolium as potential VEGFR2 inhibitors: synthesis, X-ray structure, antiproliferative evaluations, and molecular modeling. |
AID1320444 | Activation of ROCK in HUVEC assessed as phosphorylation of myosin light chain at 50 to 500 nM after 15 mins by Western blot method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID1613394 | Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay | | | |
AID94880 | The compound was tested for the concentration to inhibit 50% of colon KM20L2 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1555134 | Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
| Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. |
AID1651891 | Induction in necrosis in tumor of BALB/C mouse implanted with mouse 4T1 cells harboring firefly luciferase reporter gene at 120 mg/kg, ip measured after 72 to 96 hrs by hematoxylin and eosin staining based assay (Rvb = 46%) | 2020 | Journal of natural products, 04-24, Volume: 83, Issue:4
| Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia. |
AID1064369 | Cytotoxicity against human Jurkat/A4 cells assessed as cell death at 1 uM after 48 hrs by trypan blue exclusion assay relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID214184 | Percentage inhibition of colchicine binding to tubulin by compound was evaluated | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID228626 | Inhibition of tubulin polymerization | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
AID616992 | Antitumor activity against human MDA-MB-231 xenografted in mouse assessed as tumor growth inhibition at 150 mg/kg administered on day 1 and 5 | 2011 | Journal of medicinal chemistry, Sep-08, Volume: 54, Issue:17
| Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. |
AID1690563 | Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 50 mg/kg, iv qod for 14 to 29 days relative to control | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. |
AID1338006 | Antiproliferative activity against human Caov3 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1315233 | Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID146555 | The compound was tested for the concentration to inhibit 50% lung-NSC NCI-H460 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1059958 | Antitumor activity against human MNNG-HOS cells xenografted in Balb/c-nu mouse assessed as tumor growth inhibition at 50 mg/kg, ip administered once every 3 days for 9 days measured on day 18 relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Nov-27, Volume: 56, Issue:22
| Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. |
AID202156 | The compound was tested for the concentration to inhibit 50% of melanoma SK-MEL-5 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID1064349 | Induction of apoptosis in human Jurkat/A4 cells assessed as small cell fragments with unequally segregated chromosomes enclosed by cell membrane after 48 hrs by May-Grunwald-Giemsa staining-based microscopic analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1411796 | Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1411800 | Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1555136 | Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
| Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. |
AID1337994 | Antimitotic activity in sea urchin embryo assessed as cleavage arrest exposed 8 to 15 mins after fertilization 45 to 55 mins before first mitotic cycle completion measured at 2.5 to 5.5 hrs post dose | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID128971 | Vascular shutdown expressed as vessel density decrease in percent of the control at the dose of 100 mg/kg | 2003 | Bioorganic & medicinal chemistry letters, May-05, Volume: 13, Issue:9
| Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. |
AID1613404 | Induction of apoptosis in human HeLa cells assessed as necrotic cells at 0.05 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.05%) | | | |
AID1315229 | Antimitotic activity against sea urchin Paracentrotus lividus L embryo assessed as induction of embryo spinning | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID481680 | Cytotoxicity against Paracentrotus lividus embryo assessed as embryo spinning after 9 to 12 hrs fertilization and 0.5 to 20 hrs treatment | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. |
AID1338008 | Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1197842 | Antiproliferative activity against bovine BAEC cells after 3 days by Coulter counter method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. |
AID1064370 | Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID330413 | Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 10 mg/kg, ip after 24 hrs | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. |
AID657877 | Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID142305 | Evaluated for growth inhibition (anticancer activity) of Murine P388 lymphocytic leukemia cell line | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
AID1315235 | Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID89699 | Evaluated for growth inhibition (anticancer activity) of Human CNS cancer SF-295 cell line | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
AID1613456 | Antitumor activity against human HeLa cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg, iv administered every other day up to 20 days relative to control | | | |
AID214160 | The compound was tested for the concentration to inhibit 50% of tubulin polymerization. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID8106 | The compound was tested for the concentration to inhibit 50% of renal A498 cell lines. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID452612 | Antivascular activity in HUVEC cells assessed as change in cell shape at 1 uM after 1 hr by fluorescent-labeled high molecular weight F-dextran permeability assay | 2009 | Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22
| Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. |
AID1064341 | Induction of apoptosis in human Jurkat cells assessed as caspase 9 activation at 15 nM after 48 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1064339 | Induction of apoptosis in human Jurkat cells assessed as caspase 2 activation at 15 nM after 24 to 48 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1337995 | Antimitotic activity in sea urchin free-swimming blastulae assessed as microtubule destabilization by measuring embryo spinning exposed 8 to 10 hrs after fertilization measured after 15 mins to 20 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1320437 | Disruption of interphase microtubule in HUVEC assessed as formation of actin stress fiber at 250 nM preincubated for 30 mins followed by compound washout measured after 60 mins by DAPI staining-based immunofluorescence assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID330415 | Cytotoxicity against mouse MHEC5-T cells after 1 hr by MTT assay | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. |
AID657876 | Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID657880 | Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3
| Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. |
AID1064330 | Induction of apoptosis in human Jurkat/A4 cells assessed as reduction of XIAP expression at 150 nM after 24 hrs Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1055628 | Inhibition of calf brain tubulin polymerization after 15 mins by UV-visible spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
| Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents. |
AID330417 | Growth inhibition of mouse P388 cells | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. |
AID1550785 | Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. |
AID1064346 | Cell cycle arrest in human Jurkat/A4 cells assessed as accumulation at sub-G1 phase at 150 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 17.1%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1382775 | Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. |
AID1337993 | Antimitotic activity in sea urchin embryo assessed as cleavage alteration exposed 8 to 15 mins after fertilization 45 to 55 mins before first mitotic cycle completion measured at 2.5 to 5.5 hrs post dose | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1064318 | Induction of apoptosis in human Jurkat/A4 cells assessed as active caspase 3 expression at 150 nM after 48 hrs by FITC-conjugated flow cytometric analysis (Rvb = 1.1%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1550786 | Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. |
AID1690541 | Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay | 2020 | European journal of medicinal chemistry, Apr-01, Volume: 191 | Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. |
AID421860 | Antitumor activity against human NCI-H460 cells by sulforhodamine B assay | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3
| Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. |
AID1613390 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | | | |
AID106520 | In vitro cytotoxicity evaluated in mouse heart endotheliaoma cell (MHEC5-T) after incubation of the cells for 5 days | 2003 | Bioorganic & medicinal chemistry letters, May-05, Volume: 13, Issue:9
| Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. |
AID1411799 | Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1064327 | Induction of apoptosis in human Jurkat/A4 cells assessed as Bcl-2 expression at 150 nM after 24 to 48 hrs Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID376527 | Antibacterial activity against Neisseria gonorrhoeae by disk susceptibility test | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7
| Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane. |
AID246826 | Effective dose against murine P388 leukemia cell line | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID1197841 | Antiproliferative activity against human HMEC1 cells after 4 days by Coulter counter method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. |
AID1320432 | Disruption of interphase microtubule in HUVEC assessed as formation of actin stress fiber at 250 nM after 30 mins by phalloidin/DAPI staining-based immunofluorescence assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID1197839 | Antiproliferative activity against human CEM cells after 96 hrs by Coulter counter method | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. |
AID443468 | Cytotoxicity against human MCF7 cells by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24
| Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. |
AID1411798 | Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors. |
AID1064333 | Induction of apoptosis in human Jurkat cells assessed as reduction of XIAP expression at 15 nM after 24 hrs Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1315230 | Growth inhibition of human A549 cells by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1320431 | Disruption of interphase microtubule in HUVEC assessed as change in cell morphology at 250 nM after 30 mins by DAPI staining-based immunofluorescence assay | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
| Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. |
AID1064335 | Induction of apoptosis in human Jurkat/A4 cells assessed as caspase 2 activation at 150 nM after 24 to 48 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1064323 | Induction of apoptosis in human Jurkat cells assessed as active caspase 3 expression at 15 nM after 24 hrs by FITC-conjugated flow cytometric analysis (Rvb = 3.3%) | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1382774 | Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. |
AID1613392 | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | | | |
AID247272 | Growth inhibition against human pancreas carcinoma cell line (BxPC-3) | 2005 | Journal of medicinal chemistry, Jun-16, Volume: 48, Issue:12
| Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. |
AID1315232 | Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1064348 | Induction of apoptosis in human Jurkat/A4 cells assessed as micronuclei formation after 48 hrs by May-Grunwald-Giemsa staining-based microscopic analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID1064362 | Cell cycle arrest in human Jurkat/A4 cells assessed as decrease in accumulation at G0/G1 phase at 150 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | 2014 | Bioorganic & medicinal chemistry, Jan-15, Volume: 22, Issue:2
| Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. |
AID767874 | Cytotoxicity against human DU145 cells by SRB assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9
| Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. |
AID90436 | Evaluated for growth inhibition (anticancer activity) of Human colon KM20L2 cancer cell line | 2000 | Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
| Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. |
AID767875 | Cytotoxicity against human SKOV3 cells by SRB assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9
| Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. |
AID1572282 | Antitumor activity against mouse B16 cells allografted in C57BL/6 mouse assessed as reduction in tumor burden at 30 mg/kg, ip dosing starting on day 9 post tumor injection administered qid on day 9,11, 13 and 15 relative to control | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors. |
AID1315226 | Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay | 2016 | Journal of natural products, 05-27, Volume: 79, Issue:5
| Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity. |
AID1205544 | In vivo antitumor activity against mouse BNL 1ME A.7R.1 cells allografted in Balb/c mouse assessed as reduction in tumor growth at 5 mg/kg, ip up to 8 days relative to vehicle treated control | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
| Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin. |
AID1738880 | Antitumor activity mouse E0771 cells implanted in C57BL/6 mouse assessed as reduction tumor growth at 30 mg/kg, ip administered every other day relative to control | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors. |
AID1338013 | Antiproliferative activity against human NCI-H1975 cells measured after 96 hrs by Celltiter-Glo assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies. |
AID1550787 | Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. |
AID1565962 | Antitumour activity against human A549 cells xenografted in BALB/c nude mouse assessed as tumour volume at 30 mg/kg, ip administered every other day measured at day 26 by electronic caliper method (Rvb = 2006.37 mm3) | | | |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |