Compounds > pd 144795
Page last updated: 2024-12-11

pd 144795

Cross-References

ID SourceID
PubMed CID5481003
CHEMBL ID143702
CHEMBL ID2111977
CHEMBL ID3350275
SCHEMBL ID6938250
MeSH IDM0251680

Synonyms (21)

Synonym
3-isopropoxy-5-methoxy-1-oxo-benzo[b]thiophene-2-carboxylic acid amide
3-isopropoxy-5-methoxy-1-oxo-1h-1lambda*4*-benzo[b]thiophene-2-carboxylic acid amide
bdbm50029629
148550-96-3
3-isopropoxy-5-methoxy-1-oxo-benzothiophene-2-carboxamide
benzo[b]thiophene-2-carboxamide, 5-methoxy-3-(1-methylethoxy)-, 1-oxide
pd-144795
pd 144795
CHEMBL143702 ,
CHEMBL2111977
5-methoxy-3-(1-methylethoxy)benzo(b)thiophene-2-carboxamide 1-oxide
5-methoxy-3-(1-methylethoxy)benzo(b)thiophene-2-carboxamide-1-oxide
benzo(b)thiophene-2-carboxamide, 5-methoxy-3-(1-methylethoxy)-, 1-oxide
5-methoxy-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide-1-oxide
5-methoxy-(3-(1-methylethoxy))benzo[b]thiophene-2-carboxamide-1-oxide
VCBBOEAKKOXRTJ-UHFFFAOYSA-N
SCHEMBL6938250
CHEMBL3350275
5-methoxy-1-oxo-3-[(propan-2-yl)oxy]-1h-1-benzothiophene-2-carboximidic acid
DTXSID20933427
PD160807

Research Excerpts

Treatment

ExcerptReferenceRelevance
"PD 144795 treatment markedly inhibited the TNF-induced cell expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) protein and mRNA."( Inhibition of tumor necrosis factor induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo[b]thiophene-2-carboxamide.
Boschelli, DH; Devall, LJ; Ferguson, E; Keshava, C; Newton, RS; Saxena, U; Wölle, J, 1995)		1.01
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Intercellular adhesion molecule 1Homo sapiens (human)IC50 (µMol)4.00000.00301.212210.0000AID91875
E-selectinHomo sapiens (human)IC50 (µMol)6.60000.02002.21336.6000AID63739
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (36)

Processvia Protein(s)Taxonomy
regulation of leukocyte mediated cytotoxicityIntercellular adhesion molecule 1Homo sapiens (human)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellIntercellular adhesion molecule 1Homo sapiens (human)
T cell antigen processing and presentationIntercellular adhesion molecule 1Homo sapiens (human)
positive regulation of cellular extravasationIntercellular adhesion molecule 1Homo sapiens (human)
cell adhesionIntercellular adhesion molecule 1Homo sapiens (human)
heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIntercellular adhesion molecule 1Homo sapiens (human)
leukocyte cell-cell adhesionIntercellular adhesion molecule 1Homo sapiens (human)
membrane to membrane dockingIntercellular adhesion molecule 1Homo sapiens (human)
cell adhesion mediated by integrinIntercellular adhesion molecule 1Homo sapiens (human)
adhesion of symbiont to hostIntercellular adhesion molecule 1Homo sapiens (human)
symbiont entry into host cellIntercellular adhesion molecule 1Homo sapiens (human)
receptor-mediated virion attachment to host cellIntercellular adhesion molecule 1Homo sapiens (human)
leukocyte migrationIntercellular adhesion molecule 1Homo sapiens (human)
establishment of endothelial barrierIntercellular adhesion molecule 1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeIntercellular adhesion molecule 1Homo sapiens (human)
cellular response to glucose stimulusIntercellular adhesion molecule 1Homo sapiens (human)
T cell extravasationIntercellular adhesion molecule 1Homo sapiens (human)
regulation of ruffle assemblyIntercellular adhesion molecule 1Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIntercellular adhesion molecule 1Homo sapiens (human)
cellular response to amyloid-betaIntercellular adhesion molecule 1Homo sapiens (human)
cellular response to leukemia inhibitory factorIntercellular adhesion molecule 1Homo sapiens (human)
negative regulation of endothelial cell apoptotic processIntercellular adhesion molecule 1Homo sapiens (human)
positive regulation of receptor internalizationE-selectinHomo sapiens (human)
leukocyte migration involved in inflammatory responseE-selectinHomo sapiens (human)
positive regulation of leukocyte migrationE-selectinHomo sapiens (human)
inflammatory responseE-selectinHomo sapiens (human)
heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesE-selectinHomo sapiens (human)
leukocyte cell-cell adhesionE-selectinHomo sapiens (human)
activation of phospholipase C activityE-selectinHomo sapiens (human)
calcium-mediated signalingE-selectinHomo sapiens (human)
actin filament-based processE-selectinHomo sapiens (human)
response to lipopolysaccharideE-selectinHomo sapiens (human)
response to tumor necrosis factorE-selectinHomo sapiens (human)
regulation of inflammatory responseE-selectinHomo sapiens (human)
leukocyte tethering or rollingE-selectinHomo sapiens (human)
response to interleukin-1E-selectinHomo sapiens (human)
positive regulation of leukocyte tethering or rollingE-selectinHomo sapiens (human)
response to cytokineE-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
virus receptor activityIntercellular adhesion molecule 1Homo sapiens (human)
transmembrane signaling receptor activityIntercellular adhesion molecule 1Homo sapiens (human)
integrin bindingIntercellular adhesion molecule 1Homo sapiens (human)
protein bindingIntercellular adhesion molecule 1Homo sapiens (human)
signaling receptor activityIntercellular adhesion molecule 1Homo sapiens (human)
transmembrane signaling receptor activityE-selectinHomo sapiens (human)
protein bindingE-selectinHomo sapiens (human)
sialic acid bindingE-selectinHomo sapiens (human)
phospholipase bindingE-selectinHomo sapiens (human)
metal ion bindingE-selectinHomo sapiens (human)
oligosaccharide bindingE-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
immunological synapseIntercellular adhesion molecule 1Homo sapiens (human)
extracellular spaceIntercellular adhesion molecule 1Homo sapiens (human)
plasma membraneIntercellular adhesion molecule 1Homo sapiens (human)
focal adhesionIntercellular adhesion molecule 1Homo sapiens (human)
external side of plasma membraneIntercellular adhesion molecule 1Homo sapiens (human)
cell surfaceIntercellular adhesion molecule 1Homo sapiens (human)
membraneIntercellular adhesion molecule 1Homo sapiens (human)
membrane raftIntercellular adhesion molecule 1Homo sapiens (human)
collagen-containing extracellular matrixIntercellular adhesion molecule 1Homo sapiens (human)
extracellular exosomeIntercellular adhesion molecule 1Homo sapiens (human)
plasma membraneIntercellular adhesion molecule 1Homo sapiens (human)
extracellular spaceE-selectinHomo sapiens (human)
plasma membraneE-selectinHomo sapiens (human)
caveolaE-selectinHomo sapiens (human)
clathrin-coated pitE-selectinHomo sapiens (human)
cortical cytoskeletonE-selectinHomo sapiens (human)
membrane raftE-selectinHomo sapiens (human)
perinuclear region of cytoplasmE-selectinHomo sapiens (human)
external side of plasma membraneE-selectinHomo sapiens (human)
extracellular spaceE-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID84985Inhibitory activity against intercellular adhesion molecule (ICAM)-1 mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay at 50 uM1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84992The compound was tested for cell adhesion by measuring the inhibitory concentration against Human umbilical vein endothelial cell (HUVEC) activation, using Na51CrO4 as radioligand at 50 uM1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84981Inhibitory activity against E-Selectin mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay at 50 uM1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID183586Inhibitory activity against Mycobacterium-induced foot-pad edema(MFE)at 50 mg/kg1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84799Tested for adhesion of neutrophils to human umbilical vein endothelial cell at the dose of 100 uM1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.
AID84831The compound was tested for cell adhesion by measuring the inhibitory concentration against Human umbilical vein endothelial cell (HUVEC) activation, using Na51CrO4 as radioligand.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID63739Tested for inhibition of E-selection expression by ELISA at the dose of 30 uM1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.
AID84974The compound was tested for inhibitory activity against vascular cell adhesion molecule (VCAM)-1 mediated cell adhesion in Human aortic endothelial cell culture, by using HAEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84973The compound was tested for inhibitory activity against intercellular adhesion molecule (ICAM)-1 mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84834The compound was tested for inhibitory activity against intercellular adhesion molecule (ICAM)-1 mediated cell adhesion in Human aortic endothelial cell culture, by using HAEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID179445Inhibitory activity against Mycobacterium-induced foot-pad edema(MFE)1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84833The compound was tested for inhibitory activity against E-Selectin mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID91875Tested for inhibition of ICAM expression by ELISA at the dose of 30 uM1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.
AID84826Inhibitory activity against intercellular adhesion molecule (ICAM)-1 mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID84825Inhibitory activity against E-Selectin mediated cell adhesion in Human umbilical endothelial cell culture, by using HUVEC surface expression assay.1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
AID183585Inhibitory activity against Mycobacterium-induced foot-pad edema(MFE) at 50 mg/kg1995Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.24 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		3.0950mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
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