ophiocordin: metabolite of Cordyceps ophioglossoides [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
azepinostatin: isolated from Fusarium merismoides; structure in first source; RN assigned by CAS - 63590-19-2 (ophiocordin; azepinostatin is not the same as ophiocordin) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5490846 |
| MeSH ID | M0064622 |
| PubMed CID | 5287736 |
| CHEMBL ID | 60254 |
| SCHEMBL ID | 62128 |
| MeSH ID | M0064622 |
| Synonym |
|---|
| ophiocordin |
| (4z)-4-[(2-carboxy-6-hydroxyphenyl)-hydroxymethylidene]-3-hydroxy-1-[(3r,4r)-3-[(4-hydroxybenzoyl)amino]-2,3,4,5-tetrahydro-1h-azepin-4-yl]-5-oxocyclohex-2-ene-1-carboxylic acid |
| unii-o0n0e1mp23 |
| benzoic acid, 4-(2-(((hexahydro-4-((4-hydroxybenzoyl)oxy)-1h-azepin-3-yl)amino)carbonyl)-6-hydroxybenzoyl)-3,5-dihydroxy- |
| 63590-19-2 |
| bdbm3149 |
| 2-{[2,6-dihydroxy-4-({[(3r,4r)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid |
| balanol, 1 |
| chembl60254 , |
| MEGXM0_000504 |
| ACON0_001438 |
| balanol |
| 2-[2,6-dihydroxy-4-[(3r,4r)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid |
| bdbm36607 |
| (-)-balanol |
| azepinostatin |
| gtpl8142 |
| SCHEMBL62128 |
| 2-(2,6-dihydroxy-4-(((3r,4r)-3-(4-hydroxybenzamido)azepan-4-yloxy)carbonyl)benzoyl)-3-hydroxybenzoic acid |
| 2-{[2,6-dihydroxy-4-({[(3r,4r)-3-{[(4-hydroxyphenyl)carbonyl]amino}azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid |
| 167937-47-5 |
| benzoic acid, 4-(2-carboxy-6-hydroxybenzoyl)-3,5-dihydroxy-, (3r,4r)-hexahydro-3-((4-hydroxybenzoyl)amino)-1h-azepin-4-yl ester |
| benzoic acid, 4-(2-carboxy-6-hydroxybenzoyl)-3,5-dihydroxy-, 1-(hexahydro-3-((4-hydroxybenzoyl)amino)-1h-azepin-4-yl) ester, (3r-trans)- |
| Q4850048 |
| ophiocordin;azepinostatin |
| rac-balanol |
| DTXSID201318143 |
| HY-121197 |
| CS-0080790 |
| AKOS040745594 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | Ki | 0.0053 | 0.0053 | 1.6013 | 6.0000 | AID254306 |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | IC50 (µMol) | 0.0400 | 0.0020 | 1.2409 | 9.0000 | AID1795486 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 (µMol) | 0.0148 | 0.0001 | 1.0354 | 10.0000 | AID163879; AID164004; AID1795485 |
| Protein kinase C gamma type | Homo sapiens (human) | Ki | 0.0053 | 0.0012 | 0.4253 | 6.0000 | AID254306 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 (µMol) | 0.0199 | 0.0001 | 0.5542 | 10.0000 | AID163196; AID163200; AID163340; AID163351; AID1795485; AID1795494 |
| Protein kinase C beta type | Homo sapiens (human) | Ki | 0.0053 | 0.0004 | 0.6924 | 6.0000 | AID254306 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0002 | 0.5335 | 10.0000 | AID205485 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 (µMol) | 0.0248 | 0.0001 | 0.9720 | 10.0000 | AID162844; AID165308; AID1795485; AID1795494 |
| Protein kinase C alpha type | Homo sapiens (human) | Ki | 0.0053 | 0.0002 | 1.0945 | 6.9600 | AID254306 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 (µMol) | 0.0270 | 0.0009 | 1.3241 | 9.0000 | AID164608; AID1902445 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | Ki | 0.0047 | 0.0047 | 0.9332 | 3.0000 | AID254305 |
| Beta-adrenergic receptor kinase 1 | Bos taurus (cattle) | IC50 (µMol) | 0.0350 | 0.0350 | 0.8737 | 1.3800 | AID1315720 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 (µMol) | 0.0040 | 0.0009 | 1.5482 | 9.0000 | AID1902445 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | Ki | 0.0047 | 0.0047 | 1.2009 | 3.0000 | AID254305 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 (µMol) | 0.0040 | 0.0006 | 1.4848 | 9.0000 | AID1902445 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | Ki | 0.0047 | 0.0047 | 1.2009 | 3.0000 | AID254305 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 (µMol) | 0.0113 | 0.0001 | 0.7971 | 10.0000 | AID163860; AID164046; AID1795485; AID1902373 |
| Protein kinase C eta type | Homo sapiens (human) | Ki | 0.0053 | 0.0010 | 1.1649 | 6.0000 | AID254306 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | IC50 (µMol) | 0.0420 | 0.0420 | 1.2276 | 2.5000 | AID464308 |
| Rhodopsin kinase GRK1 | Bos taurus (cattle) | IC50 (µMol) | 4.1000 | 4.1000 | 4.1000 | 4.1000 | AID1315721 |
| G protein-coupled receptor kinase 4 | Homo sapiens (human) | IC50 (µMol) | 0.2600 | 0.0699 | 0.1476 | 0.2600 | AID464310 |
| G protein-coupled receptor kinase 5 | Homo sapiens (human) | IC50 (µMol) | 0.1600 | 0.0246 | 0.2720 | 0.8300 | AID464311 |
| Beta-adrenergic receptor kinase 2 | Homo sapiens (human) | IC50 (µMol) | 0.0470 | 0.0470 | 0.5863 | 0.8620 | AID464309 |
| Protein kinase C iota type | Homo sapiens (human) | Ki | 0.0053 | 0.0053 | 3.0026 | 6.0000 | AID254306 |
| G protein-coupled receptor kinase 5 | Bos taurus (cattle) | IC50 (µMol) | 0.4400 | 0.4400 | 0.4400 | 0.4400 | AID1315722 |
| G protein-coupled receptor kinase 6 | Homo sapiens (human) | IC50 (µMol) | 0.4900 | 0.0329 | 3.1789 | 8.7000 | AID464312 |
| Protein kinase C beta type | Rattus norvegicus (Norway rat) | Ki | 0.0053 | 0.0053 | 0.0121 | 0.0190 | AID1799441 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 (µMol) | 0.0223 | 0.0001 | 0.8029 | 10.0000 | AID163686; AID163694; AID1795485; AID1795494 |
| Protein kinase C epsilon type | Homo sapiens (human) | Ki | 0.0053 | 0.0004 | 0.9797 | 6.0000 | AID254306 |
| Protein kinase C theta type | Homo sapiens (human) | Ki | 0.0053 | 0.0015 | 0.6503 | 6.0000 | AID254306 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 (µMol) | 7.4000 | 0.0001 | 2.4453 | 10.0000 | AID164196 |
| Protein kinase C zeta type | Homo sapiens (human) | Ki | 0.0053 | 0.0053 | 3.0026 | 6.0000 | AID254306 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 (µMol) | 0.0141 | 0.0001 | 0.8448 | 10.0000 | AID163378; AID163505; AID1795485 |
| Protein kinase C delta type | Homo sapiens (human) | Ki | 0.0053 | 0.0003 | 0.9489 | 6.9600 | AID254306 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | Ki | 0.0053 | 0.0053 | 1.6013 | 6.0000 | AID254306 |
| Rhodopsin kinase GRK1 | Homo sapiens (human) | IC50 (µMol) | 0.3400 | 0.0578 | 0.1586 | 0.3400 | AID464307 |
| Rhodopsin kinase GRK7 | Homo sapiens (human) | IC50 (µMol) | 0.1800 | 0.0046 | 0.0635 | 0.1800 | AID464313 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Protein kinase C beta type | Homo sapiens (human) | Kd | 0.0018 | 0.0013 | 2.7081 | 26.3240 | AID1315726 |
| Protein kinase C alpha type | Homo sapiens (human) | Kd | 0.0064 | 0.0003 | 1.7922 | 21.3520 | AID1315725 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | Kd | 0.0039 | 0.0039 | 2.9479 | 23.2450 | AID1315723 |
| cGMP-dependent protein kinase 1 | Homo sapiens (human) | Kd | 0.0016 | 0.0016 | 0.7072 | 3.8000 | AID1315724 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1345341 | Human beta adrenergic receptor kinase 1 (Beta-adrenergic receptor kinases (betaARKs)) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1345396 | Human protein kinase C eta (Eta subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345398 | Human protein kinase C zeta (Iota subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345307 | Human protein kinase C gamma (Alpha subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345320 | Human G protein-coupled receptor kinase 7 (Opsin/rhodopsin kinases) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1345401 | Human G protein-coupled receptor kinase 6 (GRK4 subfamily) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1345313 | Human G protein-coupled receptor kinase 4 (GRK4 subfamily) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1345382 | Human protein kinase C delta (Delta subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345308 | Human protein kinase C beta (Alpha subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345397 | Human protein kinase C epsilon (Eta subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345407 | Human protein kinase C alpha (Delta subfamily) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1345395 | Human beta adrenergic receptor kinase 2 (Beta-adrenergic receptor kinases (betaARKs)) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1345331 | Human G protein-coupled receptor kinase 1 (Opsin/rhodopsin kinases) | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1795485 | PKC assay from Article 10.1021/jm960581w: \\Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.\\ | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1795494 | PKC assay from Article 10.1021/jm020018f: \\Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits.\\ | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits. |
| AID1799441 | Inhibition Assay from Article 10.1016/1074-5521(95)90124-8: \\Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.\\ | 1995 | Chemistry & biology, Sep, Volume: 2, Issue:9 | Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. |
| AID1795486 | PKA assay from Article 10.1021/jm960581w: \\Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.\\ | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1799442 | Inhibition Assay from Article 10.1016/1074-5521(95)90124-8: \\Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.\\ | 1995 | Chemistry & biology, Sep, Volume: 2, Issue:9 | Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. |
| AID44948 | Inhibition of rat brain Ca 2+/Calmodulin dependent kinase | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID163694 | Inhibitory concentration against recombinant human Protein kinase C epsilon isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID165308 | Evaluated against recombinant human Protein kinase C alpha | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1315721 | Inhibition of bovine C-terminal truncated GRK1 (535 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 mins by SDS-PAGE ana | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID1902373 | Inhibition of PKCeta (unknown origin) by IMAP kinase assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. |
| AID254306 | Inhibitory constant against protein kinase C | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18 | Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
| AID163200 | Inhibitory concentration against recombinant human Protein kinase C beta 1 isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID464314 | Inhibition of PKA | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID49343 | Inhibition of rat brain Casein kinase II | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1315720 | Inhibition of bovine GRK2 S670A mutant expressed in Baculovirus expression system assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID254305 | Inhibitory constant against the protein kinase A | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18 | Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
| AID163860 | Inhibitory concentration against recombinant human Protein kinase C eta isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID164609 | Evaluated against recombinant human Protein Kinase A (PKA) | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID164004 | Inhibitory concentration against recombinant human Protein kinase C gamma isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID464308 | Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID164046 | Evaluated against recombinant human Protein kinase C eta | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID711537 | Inhibition of Protein kinase C | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Synopsis of some recent tactical application of bioisosteres in drug design. |
| AID163378 | Evaluated against recombinant human Protein kinase C delta | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID464313 | Inhibition of GRK7-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID205485 | Inhibition of src Protein Tyrosine Kinase | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1315724 | Binding affinity to human recombinant N-terminal GST-tagged PKGalpha expressed in Baculovirus infected insect Sf9 cells using RKRSRAE as substrate in presence of [gamma-32P]ATP | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID711536 | Inhibition of cAMP-dependent protein kinase | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Synopsis of some recent tactical application of bioisosteres in drug design. |
| AID1902445 | Inhibition of PKA (unknown origin) | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4 | Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. |
| AID1315726 | Binding affinity to PKCbeta2 (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID163351 | Inhibitory concentration against recombinant human Protein kinase C beta 2 isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID163196 | Evaluated against recombinant human Protein kinase C beta 1 | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1315723 | Binding affinity to PKAalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID162844 | Inhibitory concentration against recombinant human Protein kinase C alpha isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID163010 | Inhibition of Protein kinase C alpha | 2001 | Journal of medicinal chemistry, May-10, Volume: 44, Issue:10 | Computational analysis of PKA-balanol interactions. |
| AID464310 | Inhibition of GRK4-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID163505 | Inhibitory concentration against recombinant human Protein kinase C delta isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID464309 | Inhibition of GRK3-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID464312 | Inhibition of GRK6-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID464311 | Inhibition of GRK5-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID163686 | Evaluated against recombinant human Protein kinase C epsilon | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID464307 | Inhibition of GRK1-mediated bovine tubulin phosphorylation by scintillation counting | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. |
| AID1315725 | Binding affinity to PKCalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintillation spectrometry | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID163340 | Evaluated against recombinant human Protein kinase C beta 2 | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| AID1315722 | Inhibition of bovine C-terminal truncated GRK5 (561 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preincubated for 30 mins followed by ATP addition and light exposure measured after 5 to 10 mins by SDS-PAGE ana | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. |
| AID164196 | Inhibitory concentration against recombinant human Protein kinase C zeta isozyme | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID164608 | Inhibitory concentration against recombinant human cAMP-dependent Protein kinase A | 1997 | Journal of medicinal chemistry, Jan-17, Volume: 40, Issue:2 | Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
| AID163879 | Evaluated against recombinant human Protein kinase C gamma | 1996 | Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26 | Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (32.50) | 18.2507 |
| 2000's | 15 (37.50) | 29.6817 |
| 2010's | 9 (22.50) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (11.11%) | 6.00% |
| Reviews | 1 (9.09%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (88.89%) | 84.16% |
| Other | 10 (90.91%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||