| Assay ID | Title | Year | Journal | Article |
|---|
| AID1614033 | Inhibition of human recombinant calcium-independent PLA2 using PAPE as substrate assessed as reduction in 16:0 LPC formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID412231 | Inhibition of human carboxylesterase 1 after 5 mins | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID1631724 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (630 to 655 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID1101641 | Inhibition of carboxylesterase in Fischer 344 Rattus norvegicus (rat) liver microsomes using p-nitrophenyl acetate as substrate incubated for 5 min prior to substrate addition measured for 2 min by spectrophotometric analysis | 2001 | Chemical research in toxicology, Dec, Volume: 14, Issue:12
| Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. |
| AID1614045 | Inhibition of human recombinant calcium-independent PLA2 using PAPE as substrate assessed as reduction in 16:0 LPE formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1631727 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (770 to 778 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID316359 | Inhibition of rabbit liver carboxylesterase after 5 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1614031 | Inhibition of human recombinant calcium-independent PLA2 using PAPS as substrate assessed as reduction in 16:0 LPC formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614032 | Inhibition of human recombinant calcium-independent PLA2 using PAPE as substrate assessed as assessed as reduction in free AA formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614027 | Inhibition of human recombinant calcium-independent PLA2 using PAPC as substrate assessed as reduction in 16:0 LPC formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1631725 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (656 to 664 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID1631718 | Inhibition of C-terminal 6xHis-tagged human group IVA cytosolic PLA2 expressed in fall armyworm sf9 cells at 0.091 mol fraction using PAPC/arachidonyl-1-14C PAPC as substrate by mixed micelle modified Dole assay | | | |
| AID1614029 | Inhibition of human recombinant calcium-independent PLA2 using PAPC as substrate assessed as reduction in free [14C]-AA formation after 30 mins by scintillation counting | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1631723 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (542 to 562 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID1101639 | Solubility of the compound in sodium phosphate buffer at pH 7.4 | 2001 | Chemical research in toxicology, Dec, Volume: 14, Issue:12
| Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. |
| AID1631717 | Inhibition of N-terminal 6xHis-tag human group VIA calcium-independent PLA2 expressed in fall armyworm sf9 cells at 0.091 mol fraction using PAPC/arachidonyl-1-14C PAPC as substrate by mixed micelle modified Dole assay | | | |
| AID316360 | Inhibition of rabbit liver carboxylesterase after 15 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID316357 | Inhibition of human recombinant carboxylesterase 2 after 5 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1614040 | Inhibition of human recombinant calcium-independent PLA2 using PAPG as substrate assessed as reduction in 16:0 LPC formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1631721 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (481 to 493 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID1614030 | Inhibition of human recombinant calcium-independent PLA2 using PLPC as substrate assessed as reduction in free AA formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID316355 | Inhibition of human recombinant carboxylesterase 1 after 5 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1101642 | Inhibition of Trichoplusia ni (cabbage looper) juvenile hormone esterase isolated from fifth-intsar larval stage using [3H]JH 3 as substrate incubated for 10 min prior to substrate addition measured after 15 min by liquid scintillation counting | 2001 | Chemical research in toxicology, Dec, Volume: 14, Issue:12
| Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. |
| AID1631720 | Inhibition of His-tagged human group V human secretory PLA2 expressed in Escherichia coli BL21 cells at 0.091 mol fraction using PAPC/arachidonyl-1-14C PAPC as substrate by mixed micelle modified Dole assay | | | |
| AID412230 | Inhibition of human intestinal carboxylesterase after 5 mins | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID1101640 | Inhibition of Sus scrofa (pig) carboxylesterase isolated from liver in using p-nitrophenyl acetate as substrate incubated for 5 min prior to substrate addition measured for 2 min by spectrophotometric analysis | 2001 | Chemical research in toxicology, Dec, Volume: 14, Issue:12
| Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. |
| AID1631728 | Competitive-reversible inhibition of N-terminal 6xHis-tag human group VIA calcium-independent PLA2 expressed in fall armyworm sf9 cells using PAPC/arachidonyl-1-14C PAPC as substrate by mixed micelle modified Dole assay | | | |
| AID1614054 | Inhibition of human recombinant sPLA2 using PAPS as substrate assessed as reduction in 16:0 LPS formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614043 | Inhibition of human recombinant calcium-independent PLA2 using PAPA as substrate assessed as reduction in 16:0 LPA formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614028 | Inhibition of human recombinant calcium-independent PLA2 using PAPC as substrate assessed as reduction in free AA formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID412232 | Inhibition of rabbit carboxylesterase after 5 mins | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID1614047 | Inhibition of human recombinant iPLA2 assessed as reduction in free FA formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID316364 | Inhibition of human recombinant FAAH after 15 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1614034 | Inhibition of human recombinant calcium-independent PLA2 using PLPC as substrate assessed as reduction in 16:0 LPC formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614042 | Inhibition of human recombinant calcium-independent PLA2 using PAPG as substrate assessed as reduction in 16:0 LPG formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1614037 | Inhibition of human recombinant iPLA2 assessed as reduction in 16:0 LPC formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID1105261 | Toxicity in Swiss Mus musculus (mouse) measured after 6 days | 2011 | Pest management science, Aug, Volume: 67, Issue:8
| Synthesis of allylic trifluoromethyl ketones and their activity as inhibitors of the sex pheromone of the leopard moth, Zeuzera pyrina L. (Lepidoptera: Cossidae). |
| AID1614046 | Inhibition of human recombinant calcium-independent PLA2 using PAPS as substrate assessed as reduction in 16:0 LPS formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID316358 | Inhibition of human recombinant carboxylesterase 2 after 15 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID412235 | Inhibition of rabbit carboxylesterase after 24 hrs | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID1631726 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (718 to 730 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| AID1110768 | Inhibition of juvenile hormone esterase | 2003 | Bioorganic & medicinal chemistry, Nov-17, Volume: 11, Issue:23
| Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. |
| AID412234 | Inhibition of human carboxylesterase 1 after 24 hrs | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID316354 | Inhibition of pig liver carboxylesterase after 15 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID316361 | Inhibition of Manduca sexta juvenile hormone esterase | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1614035 | Inhibition of human recombinant calcium-independent PLA2 using PAPA as substrate assessed as reduction in 16:0 LPC formation after 30 mins by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID412233 | Inhibition of human intestinal carboxylesterase after 24 hrs | 2009 | Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue:1
| Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. |
| AID316356 | Inhibition of human recombinant carboxylesterase 1 after 15 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID316363 | Inhibition of human recombinant FAAH after 5 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID316362 | Inhibition of Manduca sexta juvenile hormone esterase F2591 mutant | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1614044 | Inhibition of human recombinant calcium-independent PLA2 using PAPC as substrate assessed as reduction in 16:0 LPC formation after 30 mins in presence of equal molar mixture of PAPA/PAPC/PAPE/PAPG/PAPS/PLPC by HPLC-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| Substrate-Specific Inhibition Constants for Phospholipase A |
| AID316353 | Inhibition of pig liver carboxylesterase after 5 mins | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). |
| AID1631722 | Binding affinity to Group VIA calcium-independent PLA2 (unknown origin) (514 to 524 residues) assessed as change in average deuteration level preincubated for 30 mins followed by D2O addition measured after 10 to 10000 secs by DXMS analysis | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |