Compounds > 2,8-dimercapto-6-hydroxypurine
Page last updated: 2024-11-09

2,8-dimercapto-6-hydroxypurine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID2366465
CHEMBL ID1416049
SCHEMBL ID2777107
MeSH IDM0574189

Synonyms (53)

Synonym
6-hydroxy-2-mercapto-7,9-dihydro-8h-purine-8-thione
6-hydroxy-2-sulfanyl-7,9-dihydropurine-8-thione
HMS1786H02
nsc680829
nsc-680829
2,8-dithio-6-oxypurine
6h-purin-6-one,2,3,7,8,9-hexahydro-2,8-dithioxo-
dithio-6-oxypurine
15986-32-0
uric acid,8-dithio-
wln: t56 bm dn fn hnj csh gsh iq
nsc-22715
nsc22715
purine-6-ol,8-dimercapto-
MLS000394813 ,
smr000242902
einecs 240-120-2
6h-purin-6-one, 1,2,3,7,8,9-hexahydro-2,8-dithioxo-
1,2,3,7,8,9-hexahydro-2,8-dithioxo-6h-purin-6-one
purine-6-ol, 2,8-dimercapto-
2,8-mercaptohypoxanthine
nsc 22715
NCGC00161957-01
2,8-dimercapto-6-hydroxypurine
A810077
2,8-dimercapto-7h-purin-6-ol
2,8-bis(sulfanylidene)-7,9-dihydro-3h-purin-6-one
uric acid, 2,8-dithio-
d7jfz7x71t ,
unii-d7jfz7x71t
AKOS024319370
6h-purin-6-one,1,2,3,7,8,9-hexahydro-2,8-dithioxo-
AKOS008967225
2,8-disulfanylidene-2,3,6,7,8,9-hexahydro-1h-purin-6-one
FT-0610765
CHEMBL1416049 ,
SCHEMBL2777107
NDSUZZIWNBVBKW-UHFFFAOYSA-N
2,8-dithio-6-hydroxypurine
2,8-disulfanyl-7h-purin-6-ol #
cid_2366465
2,8-dithioxo-7,9-dihydro-3h-purin-6-one
bdbm52531
5jl ,
2,8-dithioxo-1,2,3,7,8,9-hexahydro-6h-purin-6-one
DTXSID60166752
2,8-dimercapto-6-hydroxypurin
AS-68935
dithio uric acid
bdbm50182406
2,8-disulfanyl-1,9-dihydro-6h-purin-6-one
Q27455803
Z56846778
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (22)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency8.91250.004023.8416100.0000AID485290
Chain A, Beta-lactamaseEscherichia coli K-12Potency0.63100.044717.8581100.0000AID485294
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency12.55940.140911.194039.8107AID2451
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.18380.177814.390939.8107AID2147
LuciferasePhotinus pyralis (common eastern firefly)Potency25.69600.007215.758889.3584AID588342
phosphopantetheinyl transferaseBacillus subtilisPotency3.16230.141337.9142100.0000AID1490
Microtubule-associated protein tauHomo sapiens (human)Potency18.25630.180013.557439.8107AID1460; AID1468
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency10.00000.011212.4002100.0000AID1030
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency25.28550.707936.904389.1251AID504333
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.42190.035520.977089.1251AID504332
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency39.81070.036619.637650.1187AID2100
fructose-bisphosphate aldolase AOryctolagus cuniculus (rabbit)Potency39.81070.891316.576239.8107AID2794
glyceraldehyde-3-phosphate dehydrogenase isoform 1Homo sapiens (human)Potency39.81071.122011.187739.8107AID2795
pyruvate kinase PKM isoform aHomo sapiens (human)Potency28.18380.04017.459031.6228AID1631; AID1634
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency39.81070.075215.225339.8107AID485360
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency4.00750.251215.843239.8107AID504327
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency8.41260.060110.745337.9330AID485367; AID504636; AID504637
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
large T antigenBetapolyomavirus macacaeIC50 (µMol)27.20000.160024.9724100.0000AID1903
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
POsterior SegregationCaenorhabditis elegansEC50 (µMol)32.03802.201047.1808186.6810AID1964
Sodium-dependent noradrenaline transporter Homo sapiens (human)EC50 (µMol)8.29500.082031.0243168.9080AID1960
Zinc finger protein mex-5Caenorhabditis elegansEC50 (µMol)8.29500.082033.5679168.9080AID1960
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (17)

Processvia Protein(s)Taxonomy
monoamine transportSodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter transportSodium-dependent noradrenaline transporter Homo sapiens (human)
chemical synaptic transmissionSodium-dependent noradrenaline transporter Homo sapiens (human)
response to xenobiotic stimulusSodium-dependent noradrenaline transporter Homo sapiens (human)
response to painSodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine uptakeSodium-dependent noradrenaline transporter Homo sapiens (human)
neuron cellular homeostasisSodium-dependent noradrenaline transporter Homo sapiens (human)
amino acid transportSodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine transportSodium-dependent noradrenaline transporter Homo sapiens (human)
dopamine uptake involved in synaptic transmissionSodium-dependent noradrenaline transporter Homo sapiens (human)
sodium ion transmembrane transportSodium-dependent noradrenaline transporter Homo sapiens (human)
chromatin remodelingPeregrinHomo sapiens (human)
regulation of DNA-templated transcriptionPeregrinHomo sapiens (human)
positive regulation of DNA-templated transcriptionPeregrinHomo sapiens (human)
regulation of developmental processPeregrinHomo sapiens (human)
regulation of hemopoiesisPeregrinHomo sapiens (human)
regulation of transcription by RNA polymerase IIPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
actin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter transmembrane transporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
dopamine:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
protein bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
monoamine transmembrane transporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
alpha-tubulin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
metal ion bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
beta-tubulin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
histone H4K5 acetyltransferase activityPeregrinHomo sapiens (human)
histone H4K8 acetyltransferase activityPeregrinHomo sapiens (human)
histone H4K12 acetyltransferase activityPeregrinHomo sapiens (human)
DNA bindingPeregrinHomo sapiens (human)
protein bindingPeregrinHomo sapiens (human)
acetyltransferase activator activityPeregrinHomo sapiens (human)
metal ion bindingPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
plasma membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
cell surfaceSodium-dependent noradrenaline transporter Homo sapiens (human)
membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
neuronal cell body membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
presynaptic membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
plasma membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
axonSodium-dependent noradrenaline transporter Homo sapiens (human)
nucleusPeregrinHomo sapiens (human)
nucleoplasmPeregrinHomo sapiens (human)
cytoplasmPeregrinHomo sapiens (human)
cytosolPeregrinHomo sapiens (human)
plasma membranePeregrinHomo sapiens (human)
MOZ/MORF histone acetyltransferase complexPeregrinHomo sapiens (human)
histone acetyltransferase complexPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1308809Binding affinity to recombinant GST-tagged human BRPF1 expressed in Escherichia coli BL21 (DE3) after 1 hr by qPCR-based BromoScan assay2016Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
isocarbostyril
isoquinolinone : An isoquinoline containing one or more oxo groups.		2.1310isoquinolines
4-phenylpyridine
[no description available]		2.1310phenylpyridine
tricyclazole
tricyclazole: RN given refers to parent cpd. tricyclazole : A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union.		2.1310triazolobenzothiazoleantifungal agrochemical;
melanin synthesis inhibitor
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.		2.0710aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610