| Assay ID | Title | Year | Journal | Article |
|---|
| AID241329 | Inhibition of VLA-4 receptor expressed in CHO cells | 2005 | Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1
| Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist. |
| AID1686193 | Antagonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chro | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1069153 | Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1 | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | Synthesis and assay of retro-α4β1 integrin-targeting motifs. |
| AID1686199 | Antagonist activity at alphaVbeta6 in human HT-29 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromoge | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID220266 | Inhibition of [125I]VCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| The discovery of sulfonylated dipeptides as potent VLA-4 antagonists. |
| AID217352 | Inhibition of [125I]VCAM-Ig binding to Alpha-4 beta-1 (VLA-4) of Jurkat cells | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Identification of unique VLA-4 antagonists from a combinatorial library. |
| AID1686207 | Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1069154 | Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | Synthesis and assay of retro-α4β1 integrin-targeting motifs. |
| AID1686192 | Agonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromoge | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686197 | Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686203 | Agonist activity at alpha2bbeta3 in human HEL cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic ass | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686190 | Toxicity in human K562 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1069151 | Cytotoxicity against human Jurkat cells by trypan blue exclusion assay | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | Synthesis and assay of retro-α4β1 integrin-targeting motifs. |
| AID220307 | Inhibition of integrin alpha6-beta1 adhesion using K562 cells expressing alpha-6 | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID220289 | Inhibition of integrin alpha5-beta1 adhesion to K562 cells | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID1686191 | Toxicity in human HEL cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID220105 | Inhibition of integrin alpha4-beta1 binding to VCAM-Ig | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID219635 | Inhibition of integrin alpha1-beta1 adhesion using K562 cells expressing alpha-1 | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID1069149 | Cytotoxicity against human SK-MEL-24 cells by trypan blue exclusion assay | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | Synthesis and assay of retro-α4β1 integrin-targeting motifs. |
| AID1686205 | Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686198 | Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID220265 | Inhibition of [125I]MAdCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| The discovery of sulfonylated dipeptides as potent VLA-4 antagonists. |
| AID1686187 | Toxicity in human SK-MEL-24 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686204 | Antagonist activity at alpha2bbeta3 in human HEL cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID219781 | Inhibition of ICAM-1 transfected CHO cell adhesion to integrin alphaL-beta2 of human JY cells | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID220274 | Inhibition of integrin alpha4-beta7 adhesion to JY cells | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID1686196 | Agonist activity at alphaVbeta5 in human MCF7 cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic ass | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686188 | Toxicity in human MCF7 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1234091 | Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1 | 2015 | ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
| Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay. |
| AID1686201 | Antagonist activity at alpha5beta1 in human K562 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogen | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID513088 | Inhibition of Integrin alpha-4-beta-1-mediated adhesion in human jurkat cells | 2006 | Nature chemical biology, Jul, Volume: 2, Issue:7
| Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. |
| AID217347 | Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| The discovery of sulfonylated dipeptides as potent VLA-4 antagonists. |
| AID220108 | Inhibition of integrin alpha4-beta1 adhesion to Jurkat cells | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID1069150 | Drug degradation in 100% mouse serum after 120 mins | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | Synthesis and assay of retro-α4β1 integrin-targeting motifs. |
| AID218640 | Inhibition of integrin alphaIIb-beta3 adhesion to human citreated platelets | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
| AID1686189 | Toxicity in human HT-29 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| AID1686200 | Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic a | 2016 | Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
| New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |