Hepatitis A virus cellular receptor 2

A hepatitis A virus cellular receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDQ0]

Synonyms

HAVcr-2;
T-cell immunoglobulin and mucin domain-containing protein 3;
TIMD-3;
T-cell immunoglobulin mucin receptor 3;
TIM-3;
T-cell membrane protein 3

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (1)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-chloro-1h-benzimidazole-2-thiol	Homo sapiens (human)	Kd	670.0000	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
immunological synapse	cellular component	An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
anchoring junction	cellular component	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. [ISBN:0815332181]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
mediator complex	cellular component	A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]

Involved In

This protein is involved in 40 target(s):

Target	Category	Definition
adaptive immune response	biological process	An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
macrophage activation involved in immune response	biological process	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]
natural killer cell tolerance induction	biological process	Tolerance induction of natural killer cells. [GOC:jal, PMID:16546094]
regulation of tolerance induction dependent upon immune response	biological process	Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]
negative regulation of T-helper 1 type immune response	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. [GOC:add]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of myeloid dendritic cell activation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. [GOC:mah]
negative regulation of NF-kappaB transcription factor activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. [GOC:dph, GOC:rl, GOC:tb]
negative regulation of interferon-alpha production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]
negative regulation of type II interferon production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
negative regulation of interleukin-2 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
negative regulation of interleukin-3 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production. [GOC:mah]
negative regulation of interleukin-6 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
negative regulation of tumor necrosis factor production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]
positive regulation of chemokine production	biological process	Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of type II interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-1 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. [GOC:mah]
positive regulation of interleukin-4 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
negative regulation of natural killer cell activation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. [GOC:mah]
toll-like receptor 3 signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3. [GOC:add, PMID:16551253, PMID:17328678]
toll-like receptor 7 signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7. [GOC:add, PMID:16551253, PMID:17328678]
toll-like receptor 9 signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9. [GOC:add, PMID:16551253, PMID:17328678]
positive regulation of T cell proliferation	biological process	Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]
negative regulation of T cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]
positive regulation of macrophage activation	biological process	Any process that stimulates, induces or increases the rate of macrophage activation. [GOC:jl]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
defense response to Gram-positive bacterium	biological process	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]
maternal process involved in female pregnancy	biological process	A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. [GOC:dph]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
negative regulation of granulocyte colony-stimulating factor production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor. [GOC:mah]
negative regulation of defense response to bacterium	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]
positive regulation of defense response to bacterium	biological process	Any process that activates or increases the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]
positive regulation of non-canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade. [GOC:TermGenie]
negative regulation of immunological synapse formation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation. [GOC:obol]
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]