Page last updated: 2024-08-07 20:00:51

Endothelin-converting enzyme 2

An endothelin-converting enzyme 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0DPD6]

Synonyms

ECE-2;
EC 3.4.24.71

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
quininibHomo sapiens (human)IC506.420011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
metalloendopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
methyltransferase activitymolecular functionCatalysis of the transfer of a methyl group to an acceptor molecule. [ISBN:0198506732]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
transport vesicle membranecellular componentThe lipid bilayer surrounding a transport vesicle. [GOC:mah]
cytoplasmic vesicle membranecellular componentThe lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 5 target(s):

TargetCategoryDefinition
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
cell-cell signalingbiological processAny process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
peptide hormone processingbiological processThe generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:mah]
methylationbiological processThe process in which a methyl group is covalently attached to a molecule. [GOC:mah]
protein processingbiological processAny protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]