Page last updated: 2024-11-13

cc-122

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione: a pleiotropic pathway modifier with antineoplastic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24967599
CHEMBL ID3989934
SCHEMBL ID282749
MeSH IDM000611124

Synonyms (52)

Synonym
CC-122 ,
S7892
3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione
3-(5-amino-2-methyl-4-oxoquinazolin-3 (4h)-yl)piperidine-2,6-dione
3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
RSNPAKAFCAAMBH-UHFFFAOYSA-N
3-(5-amino-2-methy-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
SCHEMBL282749
AC-33084
AKOS025399378
1015474-32-4
avadomide
unii-28dzs29f59
EX-A1191
avadomide [usan]
2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-
rac-(3r)-3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione
3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)piperidine-2,6-dione
avadomide [who-dd]
avadomide [inn]
28DZS29F59 ,
cc122
cc-122avadomide
CS-5995
HY-100507
cc 122
2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-;2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-
gtpl10522
compound a [wo2014039960a1]
3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
BCP15938
cc-122;cc 122;avadomide
avadomide(cc-122)
DB14857
CHEMBL3989934
bdbm76986
us9694015, compound a
AMY16366
SB18829
CCG-267340
avadomide (usan/inn)
D11132
C71075
AS-55858
A921203
BP-27973
3-(5-amino-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)piperidine-2,6-dione
EN300-3363282
Z2256160048
SY058067
3-[5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl]piperidine-2,6-dione
mfcd29919294

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Eighty-two patients (85%) experienced ≥1 grade 3/4 treatment-emergent adverse events (AEs), most commonly neutropenia (51%), infections (24%), anemia (12%), and febrile neutropenia (10%)."( Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier.
Bouabdallah, R; Buchholz, TJ; Carpio, C; Carrancio, S; Cordoba, R; Couto, S; Damian, S; Gandhi, AK; Gharibo, M; Hagner, PR; Hege, K; Lopez-Martin, JA; Martin, A; Panizo, C; Pinto, A; Pourdehnad, M; Rasco, D; Ribrag, V; Risueño, A; Salar, A; Salles, G; Sancho, JM; Santoro, A; Schmitz, F; Trotter, MWB; Van den Neste, E; Verhoef, G; Wang, M; Wang, X; Wei, X; Weng, A; Ysebaert, L, 2020
)
0.56

Dosage Studied

ExcerptRelevanceReference
"5 mg, 28-day continuous dosing cycles)."( A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies.
Chopra, R; DiMartino, J; Gandhi, AK; Hagner, PR; Hege, K; Li, Y; Papadopoulos, KP; Pourdehnad, M; Rasco, DW; Shih, K; Wei, X, 2019
)
0.75
" Intermittent dosing schedules supported by preclinical data provide a strategy to reduce frequency and severity of neutropenia; however, the identification of optimal dosing schedules remains a clinical challenge."( Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies.
Abbiati, RA; Carrancio, S; Kasibhatla, S; Loos, R; McConnell, M; Pierce, DW; Pourdehnad, M; Ratushny, AV; Santini, CC; Trotter, MWB, 2021
)
0.62
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Protein cereblonHomo sapiens (human)IC50 (µMol)38.70000.28601.70663.0000AID1685005
Protein cereblonHomo sapiens (human)Ki16.70001.49006.580010.0000AID1685005
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
protein ubiquitinationProtein cereblonHomo sapiens (human)
positive regulation of Wnt signaling pathwayProtein cereblonHomo sapiens (human)
negative regulation of protein-containing complex assemblyProtein cereblonHomo sapiens (human)
positive regulation of protein-containing complex assemblyProtein cereblonHomo sapiens (human)
negative regulation of monoatomic ion transmembrane transportProtein cereblonHomo sapiens (human)
locomotory exploration behaviorProtein cereblonHomo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProtein cereblonHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
protein bindingProtein cereblonHomo sapiens (human)
transmembrane transporter bindingProtein cereblonHomo sapiens (human)
metal ion bindingProtein cereblonHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleusProtein cereblonHomo sapiens (human)
cytoplasmProtein cereblonHomo sapiens (human)
cytosolProtein cereblonHomo sapiens (human)
membraneProtein cereblonHomo sapiens (human)
perinuclear region of cytoplasmProtein cereblonHomo sapiens (human)
Cul4A-RING E3 ubiquitin ligase complexProtein cereblonHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1685005Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay2021ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1
Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (25.00)24.3611
2020's12 (75.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.67 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index57.82 (26.88)
Search Engine Supply Index2.02 (0.95)

This Compound (41.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (31.25%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (68.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]