| Assay ID | Title | Year | Journal | Article |
|---|
| AID385408 | Enhancement of anti-Fas antibody CH11-induced apoptosis of human HT1080 cells at 30 uM after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID704700 | Inhibition of cell proliferation in human IMR32 cells at 1 to 30 uM after 72 hrs by Alamarblue assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID1322178 | Inhibition of BCR-ABL signaling pathway in human K562 cells assessed as suppression of STAT5 phosphorylation at 100 uM after 8 hrs in presence of imatinib by Western blot analysis | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
| Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. |
| AID1845880 | Antimalarial activity against Plasmodium falciparum D10 incubated for 48 hrs by [3H]hypoxanthine incorporation assay | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Metalloaminopeptidases of the Protozoan Parasite |
| AID704699 | Induction of apoptosis in human IMR32 cells assessed as activation of caspase 3/7 at 30 uM after 24 hrs by fluorescence assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID385410 | Inhibition of flag-tagged cIAP1 production in human HT1080 cells assessed as ubiquitinated cIAP1 accumulation in presence of MG132 at 30 uM | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID408303 | Binding affinity to human BIR3 domain of cIAP1 by fluorescence polarization assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs. |
| AID670300 | Induction of cIAP1 protein degradation in human HT1080 cells at 0.1 to 10 uM after 6 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
| Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist. |
| AID385409 | Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID704696 | Induction of apoptosis in human HT1080 cells assessed as activation of caspase 3/7 at 30 uM after 24 hrs by fluorescence assay in presence of etoposide | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID704695 | Induction of apoptosis in human HT1080 cells assessed as activation of caspase 3/7 at 30 uM after 24 hrs by fluorescence assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID385412 | Enhancement of cisplatin-induced apoptosis of human HT1080 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID385414 | Enhancement of camptothecin-induced apoptosis of human HT1080 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID385413 | Enhancement of etoposide-induced apoptosis of human HT1080 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID704704 | Displacement of DanBE from to GST-tagged cIAP1 BIR3 domain after 5 mins by Fluorescence polarization assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID408061 | Degradation promoting activity of FLAG tagged cIAP1 expressed in human HT1080 cells after 3 hrs by Western blotting analysis | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs. |
| AID1387911 | Induction of AR/cIAP1 interaction in human 22Rv1 cells assessed as ubiquitin proteasome system mediated androgen receptor protein degradation at 30 uM in presence of 1-benzyl-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile after 6 hrs by Western | 2018 | Journal of medicinal chemistry, 01-25, Volume: 61, Issue:2
| Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. |
| AID1322180 | Inhibition of BCR-ABL signaling pathway in human K562 cells assessed as suppression of CrkL phosphorylation at 100 uM after 8 hrs in presence of imatinib by Western blot analysis | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
| Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. |
| AID1322181 | Inhibition of BCR-ABL phosphorylation in human K562 cells at 100 uM after 8 hrs in presence of imatinib by Western blot analysis | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
| Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. |
| AID704688 | Binding affinity to Flag-tagged cIAP1/CRABP2 expressed in human HT1080 cells assessed as induction in CRABP-2 degradation at 1000 uM by Western blot analysis | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID704694 | Induction of apoptosis in human HT1080 cells after 24 hrs by lactate dehydrogenase assay in presence of etoposide | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID1322183 | Effect on BCR-ABL protein levels in human K562 cells assessed as BCR-ABL to beta-tubulin ratio at 100 uM after 8 hrs in presence of imatinib by Western blot analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
| Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. |
| AID385411 | Enhancement of actinomycin D-induced apoptosis of human HT1080 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin. |
| AID704693 | Induction of apoptosis in human HT1080 cells at 1 to 30 uM after 24 hrs by lactate dehydrogenase assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Development of target protein-selective degradation inducer for protein knockdown. |
| AID1845879 | Inhibition of recombinant Plasmodium falciparum A-M17 assessed as inhibition constant using H-Leu-NHMec as substrate | 2021 | Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
| Metalloaminopeptidases of the Protozoan Parasite |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |