5-amidinoindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	122670
CHEMBL ID	26490
SCHEMBL ID	563181
MeSH ID	M0104078

Synonyms (12)

Synonym
CHEMBL26490 ,
5-amidinoindole
1h-indole-5-carboximidamide
AKOS006352033
71889-75-3
bdbm50027306
1h-indole-5-carboxamidine ,
AB18264
SCHEMBL563181
FT-0756503
CS-0455193
EN300-1839766

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Prothrombin	Bos taurus (cattle)	Ki	7.6800	0.0011	2.0694	8.3700	AID213272
Plasminogen	Homo sapiens (human)	Ki	112.0000	0.0170	1.1560	4.4000	AID157985
Urokinase-type plasminogen activator	Homo sapiens (human)	Ki	131.0000	0.0170	2.6268	7.0000	AID215664
Cationic trypsin	Bos taurus (cattle)	Ki	29.1000	0.0000	1.0753	9.0000	AID215197
Serine protease hepsin	Homo sapiens (human)	Ki	500.0000	0.0005	0.1917	0.8350	AID1255807
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (56)

Process	via Protein(s)	Taxonomy
proteolysis	Prothrombin	Bos taurus (cattle)
acute-phase response	Prothrombin	Bos taurus (cattle)
positive regulation of blood coagulation	Prothrombin	Bos taurus (cattle)
protein polymerization	Prothrombin	Bos taurus (cattle)
proteolysis	Plasminogen	Homo sapiens (human)
blood coagulation	Plasminogen	Homo sapiens (human)
negative regulation of cell population proliferation	Plasminogen	Homo sapiens (human)
negative regulation of cell-substrate adhesion	Plasminogen	Homo sapiens (human)
extracellular matrix disassembly	Plasminogen	Homo sapiens (human)
tissue regeneration	Plasminogen	Homo sapiens (human)
fibrinolysis	Plasminogen	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Plasminogen	Homo sapiens (human)
myoblast differentiation	Plasminogen	Homo sapiens (human)
muscle cell cellular homeostasis	Plasminogen	Homo sapiens (human)
tissue remodeling	Plasminogen	Homo sapiens (human)
biological process involved in interaction with symbiont	Plasminogen	Homo sapiens (human)
negative regulation of fibrinolysis	Plasminogen	Homo sapiens (human)
positive regulation of fibrinolysis	Plasminogen	Homo sapiens (human)
trophoblast giant cell differentiation	Plasminogen	Homo sapiens (human)
labyrinthine layer blood vessel development	Plasminogen	Homo sapiens (human)
mononuclear cell migration	Plasminogen	Homo sapiens (human)
trans-synaptic signaling by BDNF, modulating synaptic transmission	Plasminogen	Homo sapiens (human)
negative regulation of cell-cell adhesion mediated by cadherin	Plasminogen	Homo sapiens (human)
positive regulation of cell migration	Urokinase-type plasminogen activator	Homo sapiens (human)
response to hypoxia	Urokinase-type plasminogen activator	Homo sapiens (human)
proteolysis	Urokinase-type plasminogen activator	Homo sapiens (human)
chemotaxis	Urokinase-type plasminogen activator	Homo sapiens (human)
signal transduction	Urokinase-type plasminogen activator	Homo sapiens (human)
blood coagulation	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of signaling receptor activity	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of plasminogen activation	Urokinase-type plasminogen activator	Homo sapiens (human)
negative regulation of plasminogen activation	Urokinase-type plasminogen activator	Homo sapiens (human)
smooth muscle cell migration	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of smooth muscle cell migration	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of cell adhesion	Urokinase-type plasminogen activator	Homo sapiens (human)
plasminogen activation	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Urokinase-type plasminogen activator	Homo sapiens (human)
urokinase plasminogen activator signaling pathway	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of cell population proliferation	Urokinase-type plasminogen activator	Homo sapiens (human)
fibrinolysis	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of fibrinolysis	Urokinase-type plasminogen activator	Homo sapiens (human)
negative regulation of fibrinolysis	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of wound healing	Urokinase-type plasminogen activator	Homo sapiens (human)
regulation of smooth muscle cell-matrix adhesion	Urokinase-type plasminogen activator	Homo sapiens (human)
proteolysis	Cationic trypsin	Bos taurus (cattle)
digestion	Cationic trypsin	Bos taurus (cattle)
proteolysis	Serine protease hepsin	Homo sapiens (human)
regulation of cell shape	Serine protease hepsin	Homo sapiens (human)
positive regulation of gene expression	Serine protease hepsin	Homo sapiens (human)
negative regulation of epithelial to mesenchymal transition	Serine protease hepsin	Homo sapiens (human)
positive regulation of plasminogen activation	Serine protease hepsin	Homo sapiens (human)
positive regulation of cell growth	Serine protease hepsin	Homo sapiens (human)
basement membrane disassembly	Serine protease hepsin	Homo sapiens (human)
negative regulation of apoptotic process	Serine protease hepsin	Homo sapiens (human)
positive regulation by host of viral transcription	Serine protease hepsin	Homo sapiens (human)
negative regulation of epithelial cell proliferation	Serine protease hepsin	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of sound	Serine protease hepsin	Homo sapiens (human)
potassium ion transmembrane transport	Serine protease hepsin	Homo sapiens (human)
cochlea morphogenesis	Serine protease hepsin	Homo sapiens (human)
response to thyroid hormone	Serine protease hepsin	Homo sapiens (human)
pilomotor reflex	Serine protease hepsin	Homo sapiens (human)
positive regulation of hepatocyte proliferation	Serine protease hepsin	Homo sapiens (human)
positive regulation of thyroid hormone generation	Serine protease hepsin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Process	via Protein(s)	Taxonomy
serine-type endopeptidase activity	Prothrombin	Bos taurus (cattle)
calcium ion binding	Prothrombin	Bos taurus (cattle)
protein binding	Prothrombin	Bos taurus (cattle)
fibrinogen binding	Prothrombin	Bos taurus (cattle)
protease binding	Plasminogen	Homo sapiens (human)
endopeptidase activity	Plasminogen	Homo sapiens (human)
serine-type endopeptidase activity	Plasminogen	Homo sapiens (human)
signaling receptor binding	Plasminogen	Homo sapiens (human)
protein binding	Plasminogen	Homo sapiens (human)
serine-type peptidase activity	Plasminogen	Homo sapiens (human)
enzyme binding	Plasminogen	Homo sapiens (human)
kinase binding	Plasminogen	Homo sapiens (human)
protein domain specific binding	Plasminogen	Homo sapiens (human)
apolipoprotein binding	Plasminogen	Homo sapiens (human)
protein-folding chaperone binding	Plasminogen	Homo sapiens (human)
protein antigen binding	Plasminogen	Homo sapiens (human)
serine-type endopeptidase activity	Urokinase-type plasminogen activator	Homo sapiens (human)
protein binding	Urokinase-type plasminogen activator	Homo sapiens (human)
endopeptidase activity	Cationic trypsin	Bos taurus (cattle)
serine-type endopeptidase activity	Cationic trypsin	Bos taurus (cattle)
protein binding	Cationic trypsin	Bos taurus (cattle)
metal ion binding	Cationic trypsin	Bos taurus (cattle)
serpin family protein binding	Cationic trypsin	Bos taurus (cattle)
serine-type endopeptidase activity	Serine protease hepsin	Homo sapiens (human)
protein binding	Serine protease hepsin	Homo sapiens (human)
peptidase activity	Serine protease hepsin	Homo sapiens (human)
serine-type peptidase activity	Serine protease hepsin	Homo sapiens (human)
serine-type exopeptidase activity	Serine protease hepsin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Process	via Protein(s)	Taxonomy
extracellular region	Plasminogen	Homo sapiens (human)
extracellular space	Plasminogen	Homo sapiens (human)
plasma membrane	Plasminogen	Homo sapiens (human)
external side of plasma membrane	Plasminogen	Homo sapiens (human)
cell surface	Plasminogen	Homo sapiens (human)
platelet alpha granule lumen	Plasminogen	Homo sapiens (human)
collagen-containing extracellular matrix	Plasminogen	Homo sapiens (human)
extracellular exosome	Plasminogen	Homo sapiens (human)
blood microparticle	Plasminogen	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Plasminogen	Homo sapiens (human)
glutamatergic synapse	Plasminogen	Homo sapiens (human)
extracellular space	Plasminogen	Homo sapiens (human)
extracellular region	Urokinase-type plasminogen activator	Homo sapiens (human)
extracellular space	Urokinase-type plasminogen activator	Homo sapiens (human)
plasma membrane	Urokinase-type plasminogen activator	Homo sapiens (human)
focal adhesion	Urokinase-type plasminogen activator	Homo sapiens (human)
external side of plasma membrane	Urokinase-type plasminogen activator	Homo sapiens (human)
cell surface	Urokinase-type plasminogen activator	Homo sapiens (human)
specific granule membrane	Urokinase-type plasminogen activator	Homo sapiens (human)
extracellular exosome	Urokinase-type plasminogen activator	Homo sapiens (human)
tertiary granule membrane	Urokinase-type plasminogen activator	Homo sapiens (human)
serine protease inhibitor complex	Urokinase-type plasminogen activator	Homo sapiens (human)
protein complex involved in cell-matrix adhesion	Urokinase-type plasminogen activator	Homo sapiens (human)
serine-type endopeptidase complex	Urokinase-type plasminogen activator	Homo sapiens (human)
extracellular space	Urokinase-type plasminogen activator	Homo sapiens (human)
serine protease inhibitor complex	Cationic trypsin	Bos taurus (cattle)
nuclear membrane	Serine protease hepsin	Homo sapiens (human)
endoplasmic reticulum membrane	Serine protease hepsin	Homo sapiens (human)
plasma membrane	Serine protease hepsin	Homo sapiens (human)
cell-cell junction	Serine protease hepsin	Homo sapiens (human)
cell surface	Serine protease hepsin	Homo sapiens (human)
membrane	Serine protease hepsin	Homo sapiens (human)
apical plasma membrane	Serine protease hepsin	Homo sapiens (human)
neuronal cell body	Serine protease hepsin	Homo sapiens (human)
extracellular exosome	Serine protease hepsin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID157985	Inhibition constant against human plasminogen	1983	Journal of medicinal chemistry, Feb, Volume: 26, Issue:2	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
AID215197	Inhibition constant against bovine trypsin	1983	Journal of medicinal chemistry, Feb, Volume: 26, Issue:2	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
AID1255807	Inhibition of human recombinant hepsin by fluorescence based assay using 65 uM BOC-Gln-Arg-Arg -AMC as substrate	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.
AID215664	Inhibition constant against Urokinase	1983	Journal of medicinal chemistry, Feb, Volume: 26, Issue:2	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
AID213272	Inhibition constant against bovine thrombin	1983	Journal of medicinal chemistry, Feb, Volume: 26, Issue:2	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
AID81734	Minimum concentration required for the complete blockage of virus induced cell division.; no cytotoxicity at concentrations up to 100 uM	1983	Journal of medicinal chemistry, Feb, Volume: 26, Issue:2	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.38 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
bis(5-amidino-2-benzimidazolyl)methane bis(5-amidino-2-benzimidazolyl)methane: aromatic diamidine which has a significant suppressive effect on the cytopathology & yield of respiratory synctial (RS) virus; RN given refers to parent cpd	2.37	2	0

Condition	Relationship Strength	Studies
Experimental Hepatoma [description not available]	1.96	1
Invasiveness, Neoplasm [description not available]	2.11	1
Brazilian Spotted Fever [description not available]	1.96	1
Rocky Mountain Spotted Fever An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.	1.96	1

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