benzamide adenine nucleotide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 158378 |
| CHEMBL ID | 233434 |
| MeSH ID | M0263537 |
| Synonym |
|---|
| benzamide adenine nucleotide |
| benzamideadeninedinucleoside |
| CHEMBL233434 , |
| benzamide adenine dinucleotide |
| bdbm50203628 |
| [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3s,4r,5s)-5-(3-carbamoylphenyl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate |
| 156724-91-3 |
| adenosine 5'-(trihydrogen diphosphate), p'-5'-ester with 3-beta-d-ribofuranosylbenzamide |
| DTXSID40166119 |
| dqv , |
| [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2r,3s,4r,5s)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| NAD kinase | Homo sapiens (human) | IC50 (µMol) | 90.0000 | 0.9600 | 0.9600 | 0.9600 | AID427150 |
| NAD kinase | Homo sapiens (human) | Ki | 90.0000 | 3.2800 | 3.2800 | 3.2800 | AID293925 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| phosphorylation | NAD kinase | Homo sapiens (human) |
| NAD metabolic process | NAD kinase | Homo sapiens (human) |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | NAD kinase | Homo sapiens (human) |
| ATP metabolic process | NAD kinase | Homo sapiens (human) |
| NADP biosynthetic process | NAD kinase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| NAD+ kinase activity | NAD kinase | Homo sapiens (human) |
| protein binding | NAD kinase | Homo sapiens (human) |
| ATP binding | NAD kinase | Homo sapiens (human) |
| metal ion binding | NAD kinase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytosol | NAD kinase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID293923 | Inhibition of Mycobacterium tuberculosis NAD kinase at 1 mM | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. |
| AID293924 | Inhibition of Mycobacterium tuberculosis NAD kinase at 2 mM | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. |
| AID293922 | Inhibition of human NAD kinase at 2 mM | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. |
| AID293925 | Inhibition of human NAD kinase | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. |
| AID427149 | Inhibition of Mycobacterium tuberculosis NAD kinase by modified HPLC based assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. |
| AID293921 | Inhibition of human NAD kinase at 1 mM | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. |
| AID427150 | Inhibition of human NAD kinase by modified HPLC based assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.37) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||