Compounds > benzamide adenine nucleotide
Page last updated: 2024-12-08

benzamide adenine nucleotide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

benzamide adenine nucleotide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID158378
CHEMBL ID233434
MeSH IDM0263537

Synonyms (11)

Synonym
benzamide adenine nucleotide
benzamideadeninedinucleoside
CHEMBL233434 ,
benzamide adenine dinucleotide
bdbm50203628
[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3s,4r,5s)-5-(3-carbamoylphenyl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
156724-91-3
adenosine 5'-(trihydrogen diphosphate), p'-5'-ester with 3-beta-d-ribofuranosylbenzamide
DTXSID40166119
dqv ,
[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2r,3s,4r,5s)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
NAD kinaseHomo sapiens (human)IC50 (µMol)90.00000.96000.96000.9600AID427150
NAD kinaseHomo sapiens (human)Ki90.00003.28003.28003.2800AID293925
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
phosphorylationNAD kinaseHomo sapiens (human)
NAD metabolic processNAD kinaseHomo sapiens (human)
positive regulation of insulin secretion involved in cellular response to glucose stimulusNAD kinaseHomo sapiens (human)
ATP metabolic processNAD kinaseHomo sapiens (human)
NADP biosynthetic processNAD kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
NAD+ kinase activityNAD kinaseHomo sapiens (human)
protein bindingNAD kinaseHomo sapiens (human)
ATP bindingNAD kinaseHomo sapiens (human)
metal ion bindingNAD kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytosolNAD kinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID293923Inhibition of Mycobacterium tuberculosis NAD kinase at 1 mM2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
AID293924Inhibition of Mycobacterium tuberculosis NAD kinase at 2 mM2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
AID293922Inhibition of human NAD kinase at 2 mM2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
AID293925Inhibition of human NAD kinase2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
AID427149Inhibition of Mycobacterium tuberculosis NAD kinase by modified HPLC based assay2009Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
AID293921Inhibition of human NAD kinase at 1 mM2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
AID427150Inhibition of human NAD kinase by modified HPLC based assay2009Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		1.9910diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
thiazole-4-carboxamide adenine dinucleotide
thiazole-4-carboxamide adenine dinucleotide: structure given in first source		2.730
methotrexate
[no description available]		2.0710dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
3-(1-deoxyribofuranosyl)benzamide
3-(1-deoxyribofuranosyl)benzamide: structure given in first source		2.0710
nadp
[no description available]		2.0710
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.1710organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Lymphoid Leukemia
[description not available]		02.0710
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.		02.0710