Compounds > win 35,065-2
Page last updated: 2024-11-06

win 35,065-2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID44462219
CHEMBL ID83729
CHEMBL ID1790051
MeSH IDM0075933

Synonyms (5)

Synonym
win-35066-2
CHEMBL83729 ,
CHEMBL1790051 ,
win-35065-2
bdbm50366564
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC50 (µMol)0.92000.00081.541620.0000AID281806; AID283003
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki0.55000.00031.465610.0000AID281806; AID283003
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)IC50 (µMol)0.02300.00070.97749.7000AID64704
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.08710.00030.37088.1600AID65638
Sodium-dependent serotonin transporterHomo sapiens (human)IC50 (µMol)1.96000.00010.86458.7096AID281807; AID283004
Sodium-dependent serotonin transporterHomo sapiens (human)Ki0.17800.00000.70488.1930AID281807; AID283004
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC50 (µMol)1.99900.00030.81978.4900AID204356
Sodium-dependent dopamine transporter Homo sapiens (human)IC50 (µMol)0.02300.00071.841946.0000AID281805; AID283002
TransporterRattus norvegicus (Norway rat)IC50 (µMol)2.08500.00081.95628.8000AID145382
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (55)

Processvia Protein(s)Taxonomy
monoamine transportSodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter transportSodium-dependent noradrenaline transporter Homo sapiens (human)
chemical synaptic transmissionSodium-dependent noradrenaline transporter Homo sapiens (human)
response to xenobiotic stimulusSodium-dependent noradrenaline transporter Homo sapiens (human)
response to painSodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine uptakeSodium-dependent noradrenaline transporter Homo sapiens (human)
neuron cellular homeostasisSodium-dependent noradrenaline transporter Homo sapiens (human)
amino acid transportSodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine transportSodium-dependent noradrenaline transporter Homo sapiens (human)
dopamine uptake involved in synaptic transmissionSodium-dependent noradrenaline transporter Homo sapiens (human)
sodium ion transmembrane transportSodium-dependent noradrenaline transporter Homo sapiens (human)
monoamine transportSodium-dependent serotonin transporterHomo sapiens (human)
response to hypoxiaSodium-dependent serotonin transporterHomo sapiens (human)
neurotransmitter transportSodium-dependent serotonin transporterHomo sapiens (human)
response to nutrientSodium-dependent serotonin transporterHomo sapiens (human)
memorySodium-dependent serotonin transporterHomo sapiens (human)
circadian rhythmSodium-dependent serotonin transporterHomo sapiens (human)
response to xenobiotic stimulusSodium-dependent serotonin transporterHomo sapiens (human)
response to toxic substanceSodium-dependent serotonin transporterHomo sapiens (human)
positive regulation of gene expressionSodium-dependent serotonin transporterHomo sapiens (human)
positive regulation of serotonin secretionSodium-dependent serotonin transporterHomo sapiens (human)
negative regulation of cerebellar granule cell precursor proliferationSodium-dependent serotonin transporterHomo sapiens (human)
negative regulation of synaptic transmission, dopaminergicSodium-dependent serotonin transporterHomo sapiens (human)
response to estradiolSodium-dependent serotonin transporterHomo sapiens (human)
social behaviorSodium-dependent serotonin transporterHomo sapiens (human)
vasoconstrictionSodium-dependent serotonin transporterHomo sapiens (human)
sperm ejaculationSodium-dependent serotonin transporterHomo sapiens (human)
negative regulation of neuron differentiationSodium-dependent serotonin transporterHomo sapiens (human)
positive regulation of cell cycleSodium-dependent serotonin transporterHomo sapiens (human)
negative regulation of organ growthSodium-dependent serotonin transporterHomo sapiens (human)
behavioral response to cocaineSodium-dependent serotonin transporterHomo sapiens (human)
enteric nervous system developmentSodium-dependent serotonin transporterHomo sapiens (human)
brain morphogenesisSodium-dependent serotonin transporterHomo sapiens (human)
serotonin uptakeSodium-dependent serotonin transporterHomo sapiens (human)
membrane depolarizationSodium-dependent serotonin transporterHomo sapiens (human)
platelet aggregationSodium-dependent serotonin transporterHomo sapiens (human)
cellular response to retinoic acidSodium-dependent serotonin transporterHomo sapiens (human)
cellular response to cGMPSodium-dependent serotonin transporterHomo sapiens (human)
regulation of thalamus sizeSodium-dependent serotonin transporterHomo sapiens (human)
conditioned place preferenceSodium-dependent serotonin transporterHomo sapiens (human)
sodium ion transmembrane transportSodium-dependent serotonin transporterHomo sapiens (human)
amino acid transportSodium-dependent serotonin transporterHomo sapiens (human)
monoamine transportSodium-dependent dopamine transporter Homo sapiens (human)
neurotransmitter transportSodium-dependent dopamine transporter Homo sapiens (human)
lactationSodium-dependent dopamine transporter Homo sapiens (human)
sensory perception of smellSodium-dependent dopamine transporter Homo sapiens (human)
locomotory behaviorSodium-dependent dopamine transporter Homo sapiens (human)
response to xenobiotic stimulusSodium-dependent dopamine transporter Homo sapiens (human)
response to iron ionSodium-dependent dopamine transporter Homo sapiens (human)
dopamine transportSodium-dependent dopamine transporter Homo sapiens (human)
adenohypophysis developmentSodium-dependent dopamine transporter Homo sapiens (human)
response to nicotineSodium-dependent dopamine transporter Homo sapiens (human)
positive regulation of multicellular organism growthSodium-dependent dopamine transporter Homo sapiens (human)
regulation of dopamine metabolic processSodium-dependent dopamine transporter Homo sapiens (human)
response to cocaineSodium-dependent dopamine transporter Homo sapiens (human)
dopamine biosynthetic processSodium-dependent dopamine transporter Homo sapiens (human)
dopamine catabolic processSodium-dependent dopamine transporter Homo sapiens (human)
response to ethanolSodium-dependent dopamine transporter Homo sapiens (human)
cognitionSodium-dependent dopamine transporter Homo sapiens (human)
dopamine uptake involved in synaptic transmissionSodium-dependent dopamine transporter Homo sapiens (human)
response to cAMPSodium-dependent dopamine transporter Homo sapiens (human)
norepinephrine uptakeSodium-dependent dopamine transporter Homo sapiens (human)
prepulse inhibitionSodium-dependent dopamine transporter Homo sapiens (human)
dopamine uptakeSodium-dependent dopamine transporter Homo sapiens (human)
hyaloid vascular plexus regressionSodium-dependent dopamine transporter Homo sapiens (human)
amino acid transportSodium-dependent dopamine transporter Homo sapiens (human)
norepinephrine transportSodium-dependent dopamine transporter Homo sapiens (human)
sodium ion transmembrane transportSodium-dependent dopamine transporter Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (28)

Processvia Protein(s)Taxonomy
actin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter transmembrane transporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
neurotransmitter:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
dopamine:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
norepinephrine:sodium symporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
protein bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
monoamine transmembrane transporter activitySodium-dependent noradrenaline transporter Homo sapiens (human)
alpha-tubulin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
metal ion bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
beta-tubulin bindingSodium-dependent noradrenaline transporter Homo sapiens (human)
integrin bindingSodium-dependent serotonin transporterHomo sapiens (human)
monoatomic cation channel activitySodium-dependent serotonin transporterHomo sapiens (human)
neurotransmitter transmembrane transporter activitySodium-dependent serotonin transporterHomo sapiens (human)
serotonin:sodium:chloride symporter activitySodium-dependent serotonin transporterHomo sapiens (human)
protein bindingSodium-dependent serotonin transporterHomo sapiens (human)
monoamine transmembrane transporter activitySodium-dependent serotonin transporterHomo sapiens (human)
antiporter activitySodium-dependent serotonin transporterHomo sapiens (human)
syntaxin-1 bindingSodium-dependent serotonin transporterHomo sapiens (human)
cocaine bindingSodium-dependent serotonin transporterHomo sapiens (human)
sodium ion bindingSodium-dependent serotonin transporterHomo sapiens (human)
identical protein bindingSodium-dependent serotonin transporterHomo sapiens (human)
nitric-oxide synthase bindingSodium-dependent serotonin transporterHomo sapiens (human)
actin filament bindingSodium-dependent serotonin transporterHomo sapiens (human)
serotonin bindingSodium-dependent serotonin transporterHomo sapiens (human)
protease bindingSodium-dependent dopamine transporter Homo sapiens (human)
signaling receptor bindingSodium-dependent dopamine transporter Homo sapiens (human)
neurotransmitter transmembrane transporter activitySodium-dependent dopamine transporter Homo sapiens (human)
dopamine:sodium symporter activitySodium-dependent dopamine transporter Homo sapiens (human)
protein bindingSodium-dependent dopamine transporter Homo sapiens (human)
monoamine transmembrane transporter activitySodium-dependent dopamine transporter Homo sapiens (human)
dopamine bindingSodium-dependent dopamine transporter Homo sapiens (human)
amine bindingSodium-dependent dopamine transporter Homo sapiens (human)
protein-containing complex bindingSodium-dependent dopamine transporter Homo sapiens (human)
metal ion bindingSodium-dependent dopamine transporter Homo sapiens (human)
protein phosphatase 2A bindingSodium-dependent dopamine transporter Homo sapiens (human)
heterocyclic compound bindingSodium-dependent dopamine transporter Homo sapiens (human)
norepinephrine:sodium symporter activitySodium-dependent dopamine transporter Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
plasma membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
cell surfaceSodium-dependent noradrenaline transporter Homo sapiens (human)
membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
neuronal cell body membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
presynaptic membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
plasma membraneSodium-dependent noradrenaline transporter Homo sapiens (human)
axonSodium-dependent noradrenaline transporter Homo sapiens (human)
plasma membraneSodium-dependent serotonin transporterHomo sapiens (human)
focal adhesionSodium-dependent serotonin transporterHomo sapiens (human)
endosome membraneSodium-dependent serotonin transporterHomo sapiens (human)
endomembrane systemSodium-dependent serotonin transporterHomo sapiens (human)
presynaptic membraneSodium-dependent serotonin transporterHomo sapiens (human)
membrane raftSodium-dependent serotonin transporterHomo sapiens (human)
synapseSodium-dependent serotonin transporterHomo sapiens (human)
postsynaptic membraneSodium-dependent serotonin transporterHomo sapiens (human)
serotonergic synapseSodium-dependent serotonin transporterHomo sapiens (human)
synapseSodium-dependent serotonin transporterHomo sapiens (human)
plasma membraneSodium-dependent serotonin transporterHomo sapiens (human)
neuron projectionSodium-dependent serotonin transporterHomo sapiens (human)
cytoplasmSodium-dependent dopamine transporter Homo sapiens (human)
plasma membraneSodium-dependent dopamine transporter Homo sapiens (human)
cell surfaceSodium-dependent dopamine transporter Homo sapiens (human)
membraneSodium-dependent dopamine transporter Homo sapiens (human)
axonSodium-dependent dopamine transporter Homo sapiens (human)
neuron projectionSodium-dependent dopamine transporter Homo sapiens (human)
neuronal cell bodySodium-dependent dopamine transporter Homo sapiens (human)
axon terminusSodium-dependent dopamine transporter Homo sapiens (human)
membrane raftSodium-dependent dopamine transporter Homo sapiens (human)
postsynaptic membraneSodium-dependent dopamine transporter Homo sapiens (human)
dopaminergic synapseSodium-dependent dopamine transporter Homo sapiens (human)
flotillin complexSodium-dependent dopamine transporter Homo sapiens (human)
axonSodium-dependent dopamine transporter Homo sapiens (human)
presynaptic membraneSodium-dependent dopamine transporter Homo sapiens (human)
plasma membraneSodium-dependent dopamine transporter Homo sapiens (human)
neuronal cell body membraneSodium-dependent dopamine transporter Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (45)

Assay IDTitleYearJournalArticle
AID127476Binding affinity against human monoclonal antibody (mAb) 2E2 relative to cocaine by ELISA method.2004Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody.
AID145382Inhibition of [3H]mazindol binding to Norepinephrine transporter1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
AID145531Ratio of IC50(NE) to the IC50(DA)1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
AID283002Displacement of [3H]WIN-35428 from DAT2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
AID281805Displacement of [3H]WIN-35428 from DAT2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281812Locomotor activity in CD1 mouse assessed as stimulation at 3 mg/kg, ip after 4 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID283003Displacement of [3H]nisoxetine from NET2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
AID281809Locomotor activity in CD1 mouse assessed as stimulation at 3 mg/kg, ip after 1 hr relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281844Drug discrimination effect in CD Albino rat assessed as percent of rat choosing cocaine lever at 0.56 mg/kg, ip2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281815Locomotor activity in CD1 mouse assessed as stimulation at 10 mg/kg, ip after 3 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281810Locomotor activity in CD1 mouse assessed as stimulation at 3 mg/kg, ip after 2 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281832Locomotor activity in CD1 mouse assessed as stimulation at 1 mg/kg, ip after 4 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281830Locomotor activity in CD1 mouse assessed as stimulation at 1 mg/kg, ip after 2 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID204356Inhibition of [3H]paroxetine binding to Serotonin transporter1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
AID283004Displacement of [3H]paroxetine from 5HTT2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
AID281852Activity in CD1 mouse assessed as hyperactivity at 1 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID65635Concentration inhibiting [3H]WIN-35248 binding to cocaine receptor site on dopamine transporter in rat striatal membranes1992Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.
AID281814Locomotor activity in CD1 mouse assessed as stimulation at 10 mg/kg, ip after 2 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281874Activity in CD1 mouse assessed as convulsions at 100 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281806Displacement of [3H]nisoxetine from NET2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281807Displacement of [3H]paroxetine from 5HTT2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281882Locomotor activity in ip dosed CD1 mouse after 1 hr relative to cocaine2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281858Activity in CD1 mouse assessed as stereotypy at 10 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281825Locomotor activity in CD1 mouse assessed as stimulation at 0.3 mg/kg, ip after 1 hr relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281845Drug discrimination effect in CD Albino rat assessed as percent of rat choosing cocaine lever at 1 mg/kg, ip2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281829Locomotor activity in CD1 mouse assessed as stimulation at 1 mg/kg, ip after 1 hr relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281831Locomotor activity in CD1 mouse assessed as stimulation at 1 mg/kg, ip after 3 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID65638Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligand2000Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.
AID281813Locomotor activity in CD1 mouse assessed as stimulation at 10 mg/kg, ip after 1 hr relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281842Drug discrimination effect in CD Albino rat assessed as percent of rat choosing cocaine lever at 0.17 mg/kg, ip2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281867Activity in CD1 mouse assessed as stereotypy at 100 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID204866Ratio of IC50(5-HT) to the IC50(DA)1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
AID281843Drug discrimination effect in CD Albino rat assessed as percent of rat choosing cocaine lever at 0.3 mg/kg, ip2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281859Activity in CD1 mouse assessed as circling at 10 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281857Activity in CD1 mouse assessed as hyperactivity at 10 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281811Locomotor activity in CD1 mouse assessed as stimulation at 3 mg/kg, ip after 3 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281828Locomotor activity in CD1 mouse assessed as stimulation at 0.3 mg/kg, ip after 4 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281808Locomotor activity in ip dosed CD1 mouse in peak hour2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281853Activity in CD1 mouse assessed as stereotypy at 1 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281841Cocaine discrimination in ip dosed CD Albino rat2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281827Locomotor activity in CD1 mouse assessed as stimulation at 0.3 mg/kg, ip after 3 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID64704Inhibition of [3H]WIN-35428l binding to Dopamine transporter1992Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
AID281869Activity in CD1 mouse assessed as straub tail at 100 mg/kg, ip after 4 hrs2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281816Locomotor activity in CD1 mouse assessed as stimulation at 10 mg/kg, ip after 4 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
AID281826Locomotor activity in CD1 mouse assessed as stimulation at 0.3 mg/kg, ip after 2 hrs relative to control2004Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's4 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bupropion
Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.. bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.		210aromatic ketone;
monochlorobenzenes;
secondary amino compound		antidepressant;
environmental contaminant;
xenobiotic
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane
[no description available]		210diarylmethane
carbetapentane
carbetapentane: RN given refers to parent cpd		210benzenes
vanoxerine
vanoxerine: structure given in first source. vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.		210ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor
gbr 12935
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).		210ether;
N-alkylpiperazine;
tertiary amino compound		dopamine uptake inhibitor
ifenprodil
ifenprodil: NMDA receptor antagonist		210piperidines
nomifensine
Nomifensine: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266). nomifensine : An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.		210isoquinolinesdopamine uptake inhibitor
caramiphen
caramiphen: structure		210benzenes
tropine
[no description available]		2.0210
exp561
EXP561: inhibitor of 5-HT uptake; RN given refers to parent cpd		210
rimcazole
rimcazole: RN given refers to (cis)-isomer; structure given in first source		210carbazoles
atomoxetine
atomoxetine : A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.		210aromatic ether;
secondary amino compound;
toluenes		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
xenobiotic
diclofensine
diclofensine: RN given refers to parent cpd(+-)-isomer; structure given in first source		210
n-methylscopolamine
N-Methylscopolamine: A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.		2.0210
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine: structure given in first source. 1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine : A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and benzothiophen-2-yl groups attached at position 1. A potent dopamine re-uptake inhibitor with a behavioral profile different from that of phencyclidine (PCP) and similar to that of cocaine.		2101-benzothiophenes;
piperidines;
tertiary amino compound		dopamine uptake inhibitor
pre 084
2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate: structure given in first source		210morpholines
ecgonine
ecgonine: RN given refers to (1R-(exo,exo))-isomer; structure. ecgonine : A tropane alkaloid that consists of tropane bearing carboxy and hydroxy substituents at positions 2 and 3 respectively and having (1R,2R,3S,5S)-configuration. It is both a metabolite of and a precursor to cocaine.		2.0210tropane alkaloid
cocaine
Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.		3.150benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
benztropine
Benztropine: A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.. benzatropine : Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.		2.4120diarylmethane
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane
[no description available]		2.4120diarylmethane
rti-113
RTI-113: selectively binds to dopamine transporter		2.0210
scopolamine hydrobromide
[no description available]		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials