| Assay ID | Title | Year | Journal | Article |
|---|
| AID60175 | The effective dose to produce a maximum increase in dP/dt diastolic blood pressure and heart rate | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID157161 | In vitro inhibition of PDE-V isolated from porcine pulmonary artery. | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| AID59591 | Maximum percentage change in dP/dt, diastolic blood pressure and heart rate produced by the compound at a dose 0.3 mg/kg | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID59301 | The effective dose to produce the 30%decrease in diastolic blood pressure. | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID157151 | Effective dose against PDE-III for increase in contractility following administration to anaesthetised dogs | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| AID157159 | In vitro inhibition of PDE-IV isolated from guinea pig ventricle at 100 uM. | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| AID49059 | Response ratio = (percent increase to drug)/(percent increase to 10 E-4 M isoproterenol) | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID59725 | Maximum percentage increase in heart rate produced by the compound at a dose 0.3 mg/kg | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID157152 | Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| AID59485 | Compound tested for contractility in anesthetized dog when administered intravenously. | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID60173 | Tested in anesthetized dog for its inotropic activity after intravenous administration | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
| Imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyrazines: the role of nitrogen position in inotropic activity. |
| AID49060 | Response ratio = (percent increase to drug)/(percent increase to 10 E-5 M isoproterenol) | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID157154 | Percent inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle at 10 uM (or 100 uM) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| AID50434 | Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M. | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID47761 | Inotropic activity in cat papillary muscle at 10e-5 M expressed as percent of control | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
| Imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyrazines: the role of nitrogen position in inotropic activity. |
| AID59622 | Percent change in heart rate in anesthetized dog | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID59124 | The effective dose was measured to produce the 10%increase in heart rate. | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID79659 | In vitro concentration required to give a 50% increase in basal contractile force in an isolated paced guinea pig papillary muscle preparation | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID59623 | Percent change in mean arterial blood pressure in anesthetized dog | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID50436 | Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M. | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID59569 | Maximum percentage decrease in diastolic blood pressure produced by the compound at a dose 1 mg/kg | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
| Inotropic "A" ring substituted sulmazole and isomazole analogues. |
| AID233939 | Relative positive inotropic activity (ED50) and PDE 3 inhibition (IC50) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |