Compounds > urolithin d
Page last updated: 2024-12-11

urolithin d

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Description

urolithin D: has antiproliferative activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5482042
CHEMBL ID6338
CHEBI ID174390
SCHEMBL ID7980209
MeSH IDM000602213

Synonyms (20)

Synonym
urolithin d
131086-98-1
CHEBI:174390
3,4,8,9-tetrahydroxybenzo[c]chromen-6-one
CHEMBL6338 ,
6h-dibenzo(b,d)pyran-6-one, 3,4,8,9-tetrahydroxy-
SCHEMBL7980209
6h-dibenzo[b,d]pyran-6-one, 3,4,8,9-tetrahydroxy-
DTXSID70156886
urolithin-d
JVT9VXW2DJ
3,4,8,9-tetrahydroxyurolithin
3,4,8,9-tetrakis(oxidanyl)benzo(c)chromen-6-one
bdbm50215545
3,4,8,9-tetrahydroxy-6h-benzo[c]chromen-6-one
A904631
3,4,8,9-tetrahydroxy-6h-dibenzo[b,d]pyran-6-one
CS-0113121
HY-133178
AT39292

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"A pilot intervention study was conducted in human volunteers (n = 4) to establish the bioavailability of urolithins, which are the terminal end-products of ellagitannin metabolism by the gastrointestinal microflora."( Pilot walnut intervention study of urolithin bioavailability in human volunteers.
Gehres, N; Haubner, R; Owen, RW; Pfundstein, B; Ulrich, CM; Würtele, G, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxycoumarinAny coumarin carrying at least one hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)IC50 (µMol)100.00001.80001.80001.8000AID1588078
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)IC50 (µMol)1.66800.51001.64373.1200AID1588066; AID1588079; AID1588080; AID1588081; AID1588082
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)Ki3.60901.06803.60906.1500AID1588070; AID1588071
Polypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)IC50 (µMol)2.46002.46002.46002.4600AID1588072
Polypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)IC50 (µMol)1.61001.61001.61001.6100AID1588075
Polypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)IC50 (µMol)0.33000.33000.33000.3300AID1588077
Polypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)IC50 (µMol)1.83001.83001.83001.8300AID1588076
Polypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)IC50 (µMol)0.46000.46000.46000.4600AID1588074
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)Kd0.29400.29400.52970.9240AID1588067
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (42)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IIUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
mitophagyUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of transcription from RNA polymerase II promoter by glucoseUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of glycolytic processUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of gluconeogenesisUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
chromatin organizationUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of transcription by RNA polymerase IIUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein O-linked glycosylationUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
apoptotic processUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
signal transductionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
response to nutrientUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein processingUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
hemopoiesisUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
negative regulation of cell migrationUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
negative regulation of protein ubiquitinationUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
negative regulation of proteasomal ubiquitin-dependent protein catabolic processUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
response to insulinUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
circadian regulation of gene expressionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of Rac protein signal transductionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of translationUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of proteolysisUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of DNA-templated transcriptionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of insulin receptor signaling pathwayUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of lipid biosynthetic processUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of synapse assemblyUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of necroptotic processUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
cellular response to glucose stimulusUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
regulation of neurotransmitter receptor localization to postsynaptic specialization membraneUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of cold-induced thermogenesisUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
negative regulation of stem cell population maintenanceUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of stem cell population maintenanceUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
positive regulation of TORC1 signalingUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
protein O-linked glycosylation via serinePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
protein O-linked glycosylation via threoninePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
protein maturationPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
protein O-linked glycosylation via serinePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
protein O-linked glycosylation via threoninePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
viral protein processingPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
carbohydrate metabolic processPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
spermatogenesisPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
protein O-linked glycosylation via serinePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
protein O-linked glycosylation via threoninePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
protein O-linked glycosylation via serinePolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
protein O-linked glycosylation via threoninePolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
protein O-linked glycosylation via threoninePolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
O-glycan processingPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
protein O-linked glycosylationPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
protein bindingUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
phosphatidylinositol-3,4,5-trisphosphate bindingUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
acetylglucosaminyltransferase activityUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
chromatin DNA bindingUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein O-acetylglucosaminyltransferase activityUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
protein bindingPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
manganese ion bindingPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
manganese ion bindingPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
calcium ion bindingPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
manganese ion bindingPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
metal ion bindingPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
metal ion bindingPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
protein bindingPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
metal ion bindingPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
polypeptide N-acetylgalactosaminyltransferase activityPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
carbohydrate bindingPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
metal ion bindingPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (22)

Processvia Protein(s)Taxonomy
nucleusUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
nucleoplasmUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
cytosolUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
plasma membraneUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
mitochondrial membraneUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
cell projectionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
NSL complexUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
Sin3-type complexUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
glutamatergic synapseUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
histone acetyltransferase complexUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein N-acetylglucosaminyltransferase complexUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
protein-containing complexUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
extracellular regionPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
endoplasmic reticulum membranePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi stackPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
membranePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi cisterna membranePolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
perinuclear region of cytoplasmPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
extracellular regionPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
endoplasmic reticulum membranePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
membranePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
Golgi cisterna membranePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membranePolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
perinuclear region of cytoplasmPolypeptide N-acetylgalactosaminyltransferase 1Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
membranePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
Golgi cisterna membranePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
perinuclear region of cytoplasmPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
extracellular exosomePolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 3Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 10Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 13Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
perinuclear region of cytoplasmPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 6Homo sapiens (human)
Golgi membranePolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
Golgi apparatusPolypeptide N-acetylgalactosaminyltransferase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID1588102Inhibition of ppGalNAcT2 in Chinese hamster ldlD cells assessed as reduction in O-GalNAc glycosylation by measuring metabolic labelled-GalNAz signal at 40 uM incubated for 48 hrs by click chemistry assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588093Effect on ppGalNAcT6 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588079Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588083Ratio of IC50 for IC50 for human recombinant FLAG-tagged ppGalNAcT2 W282A mutant to IC50 for human recombinant FLAG-tagged ppGalNAcT22019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588070Competitive inhibition of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells using EA2 peptide as substrate by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588108Cytotoxicity against human HT-29 cells at 40 uM incubated for 48 hrs by CCK-8 assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588076Inhibition of catalytic activity of ppGalNAcT6 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588117Reduction in PDPN protein expression in human HT-29 cells at 40 uM for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588103Inhibition of ppGalNAcT2 in Chinese hamster ldlD cell lysates assessed as reduction in O-GalNAc glycosylation by measuring glycans VVA lectin expression at 0.5 to 4 uM incubated for 30 mins by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588092Effect on ppGalNAcT5 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588095Effect on ppGalNAcT10 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588072Inhibition of catalytic activity of ppGalNAcT1 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588082Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 W282A mutant expressed in HEK293 cells using EA2 peptide as substrate by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588106Inhibition of ppGalNAcT2 in human SW480 cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588119Effect on PDPN expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588121Effect on ppGalNAcT4 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588118Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in PDPN O-GalNAc glycosylation by at 40 uM incubated for 48 hrs by jacalin lectin based immunoprecipitation analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588098Effect on ppGalNAcT13 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588080Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc5AC peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588099Effect on ppGalNAcT14 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588116Anti-invasive activity in human HCT116 cells at 40 uM incubated for 48 hrs by crystal violet staining based method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588071Non-competitive inhibition of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells using UDP-GalNAc as substrate by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588073Inhibition of catalytic activity of ppGalNAcT13 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588112Antimigratory activity in human HT-29 cells at 40 uM incubated for 48 hrs by crystal violet staining based method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588089Effect on ppGalNAcT2 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588094Effect on ppGalNAcT7 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588077Inhibition of catalytic activity of ppGalNAcT10 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588091Effect on ppGalNAcT4 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588078Inhibition of catalytic activity of OGT (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588111Cytotoxicity against human RKO cells at 40 uM incubated for 48 hrs by CCK-8 assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588101Effect on ppGalNAcT16 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588120Effect on ppGalNAcT2 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588097Effect on ppGalNAcT12 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588115Antimigratory activity in human RKO cells at 40 uM incubated for 48 hrs by crystal violet staining based method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588075Inhibition of catalytic activity of ppGalNAcT3 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588068Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as association rate by SPR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588110Cytotoxicity against human SW480 cells at 40 uM incubated for 48 hrs by CCK-8 assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588104Inhibition of ppGalNAcT2 in human Jurkat cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588074Inhibition of catalytic activity of ppGalNAcT14 (unknown origin) using EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588069Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation rate by SPR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID53321Inhibition of DNA gyrase supercoiling in Escherichia coli.1998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
DNA gyrase inhibitory activity of ellagic acid derivatives.
AID1588086Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring PNA lectin expression at 20 to 60 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588096Effect on ppGalNAcT11 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588105Inhibition of ppGalNAcT2 in human HCT116 cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588087Effect on N-glycans in human HT-29 cells assessed as change in ConA expression at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588100Effect on ppGalNAcT15 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588107Inhibition of ppGalNAcT2 in human RKO cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588066Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293T cells and using 5-FAM labelled-EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588085Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring VVA lectin expression at 20 to 60 uM incubated for 48 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588090Effect on ppGalNAcT3 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588113Antimigratory activity in human HCT116 cells at 40 uM incubated for 48 hrs by crystal violet staining based method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588081Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc7 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588109Cytotoxicity against human HCT116 cells at 40 uM incubated for 48 hrs by CCK-8 assay2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588088Effect on ppGalNAcT1 expression level in human HT-29 cells at 40 uM incubated for 48 hrs by Q-PCR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588067Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation constant by SPR analysis2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588114Antimigratory activity in human SW480 cells at 40 uM incubated for 48 hrs by crystal violet staining based method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
AID1588084Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring PNA lectin signal on cell surface at 40 uM incubated for 48 hrs by DAPI staining based immunofluorescence method2019Bioorganic & medicinal chemistry, 08-01, Volume: 27, Issue:15
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's8 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.43 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.53 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		2.2110trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
nalidixic acid
[no description available]		1.99101,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic		antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		1.99103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
tert-butylhydroperoxide
tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.		2.1110alkyl hydroperoxideantibacterial agent;
oxidising agent
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.1710butan-4-olidemetabolite;
neurotoxin
6h-dibenzo-(b,d)-pyran-6-one
6H-dibenzo[b,d]pyran-6-one : A benzochromenone that is 6H-dibenzo[b,d]pyran substituted by an oxo group at position 6.		1.9910benzochromenoneplant metabolite
pyrene
pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.		2.2110ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
arctigenin
arctigenin: precursor to catechols; in many plants		2.1710lignan
secoisolariciresinol
secoisolariciresinol: RN given refers to ((R-(R*,R*))-isomer); RN for cpd without isomeric designation not available 8/89; precursor of lignans found in human urine; structure given in first source. secoisolariciresinol : A lignan that is butane-1,4-diol in which the 2 and 3 positions are substituted by 4-hydroxy-3-methoxybenzyl groups. (-)-secoisolariciresinol : An enantiomer of secoisolariciresinol having (-)-(2R,3R)-configuration.		2.1710secoisolariciresinolantidepressant;
phytoestrogen;
plant metabolite
o-desmethylangolensin
O-desmethylangolensin: structure given in first source		2.1710stilbenoid
equol
Equol: A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.		2.1710hydroxyisoflavans
2,3-bis(3'-hydroxybenzyl)butyrolactone
2,3-bis(3'-hydroxybenzyl)butyrolactone: lignan isolated from urine of humans & other mammals; RN given refers to cpd without isomeric designation; structure given in second source		2.1710lignan
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.1710
ellagic acid
[no description available]		2.7730catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
glycitein
glycitein : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.		2.17107-hydroxyisoflavone;
methoxyisoflavone		fungal metabolite;
phytoestrogen;
plant metabolite
urolithin b
urolithin B: has antiproliferative activity; structure in first source		3.3860coumarins
3,8-dihydroxy-6h-dibenzo(b,d)pyran-6-one
3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one: metabolite of ellagic acid		3.2250coumarinsgeroprotector
3,3'-di-o-methylellagic acid
3,3'-di-O-methylellagic acid: structure given in first source		2.2110
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		4.5380benzenes;
hydroxycoumarin;
methyl ketone
phytoestrogens
Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.		2.1710
urolithin c
urolithin C: inhibits cell proliferation; from Epilobium sp. herbs; structure in first source		3.0240coumarins
chebulic acid
chebulic acid: from the ripe fruits of Terminalia chebula		2.1110
ellagitannin
ellagitannin: structure; precoxin A/ praecoxin A is a purified ellagitannin. ellagitannin : A form of hydrolysable tannin produced from ellagic acid. Ellagitannins are glucosides which are readily hydrolysed by water to regenerate ellagic acid when the plants are eaten.		7.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.2110
Colorectal Cancer
[description not available]		02.2110
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.2110
Cancer of Colon
[description not available]		02.110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.110
Cancer of Prostate
[description not available]		02.1110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1110
Liver Dysfunction
[description not available]		02.1110
Liver Diseases
Pathological processes of the LIVER.		02.1110