Compounds > l-beta-threo-benzyl-aspartate
Page last updated: 2024-08-02 21:15:15

l-beta-threo-benzyl-aspartate

Description

L-beta-threo-benzyl-aspartate: structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID11622683
CHEMBL ID458273
SCHEMBL ID14498029
MeSH IDM0495549

Synonyms (19)

Synonym
NCGC00186040-01
CHEMBL458273 ,
HMS3263L05
l-beta-threo-benzyl-aspartate
LP01172
gtpl4625
(2s,3s)-2-amino-3-(phenylmethyl)butanedioic acid
l-beta-ba
CCG-222476
SCHEMBL14498029
tox21_501172
NCGC00261857-01
bdbm50197049
Q27079166
871123-98-7
(2s,3s)-2-amino-3-benzylbutanedioic acid
DTXSID501017554
SDCCGSBI-0633800.P001
NCGC00186040-02

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
dopamine D1 receptorHomo sapiens (human)Potency29.0929AID624455
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency10.5909AID1224820
arylsulfatase AHomo sapiens (human)Potency0.0379AID720538
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency7.0795AID504332
chromobox protein homolog 1Homo sapiens (human)Potency5.0119AID488953

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Excitatory amino acid transporter 1Homo sapiens (human)IC5036.9954AID1321948; AID1725868
Excitatory amino acid transporter 2Homo sapiens (human)IC5031.5526AID1321949; AID1725869
Excitatory amino acid transporter 3Homo sapiens (human)IC507.5883AID1321950; AID1725870

Bioassays (31)

Assay IDTitleYearJournalArticle
AID365686Selectivity for human EAAT3 over human EAAT2 expressed in mouse C17.2 cells2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
ISSN: 1464-3391		Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3.
AID1321950Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method2016Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19
ISSN: 1520-4804		β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences.
AID365685Selectivity for human EAAT3 over human EAAT1 expressed in mouse C17.2 cells2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
ISSN: 1464-3391		Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3.
AID1725868Inhibition of human EAAT1 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis2020ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11
ISSN: 1948-5875		β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
AID1725871Selectivity index, ratio of IC50 for human EAAT1 transfected in mouse C17.2 cells to IC50 for human EAAT3 transfected in mouse C17.2 cells incubated for 5 mins by [3H]-D-aspartate uptake assay2020ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11
ISSN: 1948-5875		β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
AID365684Inhibition of [3H]D-aspartate uptake at human EAAT3 expressed in mouse C17.2 cells at 100 uM relative to control2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
ISSN: 1464-3391		Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3.
AID1725872Selectivity index, ratio of IC50 for human EAAT2 transfected in mouse C17.2 cells to IC50 for human EAAT3 transfected in mouse C17.2 cells incubated for 5 mins by [3H]-D-aspartate uptake assay2020ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11
ISSN: 1948-5875		β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
AID1321948Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount method2016Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19
ISSN: 1520-4804		β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences.
AID1321949Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount method2016Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19
ISSN: 1520-4804		β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences.
AID1725870Inhibition of human EAAT3 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis2020ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11
ISSN: 1948-5875		β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
AID1725869Inhibition of human EAAT2 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis2020ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11
ISSN: 1948-5875		β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
AID1347050Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347058CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347049Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347405qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
ISSN: 1554-8937		High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347057CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347151Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
ISSN: 2211-1247		A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347045Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID588378qHTS for Inhibitors of ATXN expression: Validation2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1347410qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library2019Cellular signalling, 08, Volume: 60ISSN: 1873-3913A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347059CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588349qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID504836Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation2002The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
ISSN: 0021-9258		Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
ISSN: 1552-454X		A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2022Journal of enzyme inhibition and medicinal chemistry, Dec, Volume: 37, Issue:1
ISSN: 1475-6374
AID1346834Human Excitatory amino acid transporter 3 (Glutamate transporter subfamily)2005Neuropharmacology, Nov, Volume: 49, Issue:6
ISSN: 0028-3908		The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3.

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (17.65)29.6817
2010's7 (41.18)24.3611
2020's7 (41.18)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
glutamic acid
1
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical		202020204.0medium000010
2-amino-3-phenylmethoxybutanedioic acid
1
aspartic acid derivative202020204.0high000010
dl-threo-beta-benzyloxyaspartate
2
2008201612.0high000110
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
aspartic acid
2
aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter		2005201116.0high000110
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Congenital Zika Syndrome0
1
202020204.0medium000010
Contact Dermatitis0
1
201920195.0medium000010
Dermatitis, Contact0
1
201920195.0medium000010
Disease Models, Animal0
2
201920204.5medium000020
Itching0
1
201920195.0medium000010
Malaria, Falciparum0
1
2014201410.0medium000010
Plasmodium falciparum Malaria0
1
2014201410.0medium000010
Pruritus0
1
201920195.0medium000010
Zika Virus Infection0
1
202020204.0medium000010