trichostatin RK: from Streptomyces sp. RK98-A74.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 25118974 |
| CHEMBL ID | 3353922 |
| SCHEMBL ID | 10324242 |
| MeSH ID | M0417081 |
| Synonym |
|---|
| SCHEMBL10324242 |
| trichostatin rk |
| CHEMBL3353922 , |
| (2e,4e,6r)-7-[4-(dimethylamino)phenyl]-n,4,6-trimethyl-7-oxohepta-2,4-dienamide |
| bdbm50577997 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0004 | 0.6196 | 10.0000 | AID1781513 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0006 | 1.0526 | 10.0000 | AID1781513 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0001 | 0.5543 | 9.9000 | AID1781513 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0007 | 1.0260 | 9.9000 | AID1781513 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0001 | 0.7221 | 9.9700 | AID1781513 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0005 | 0.7245 | 9.9000 | AID1781513 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0003 | 0.9298 | 9.9000 | AID1781513 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0007 | 0.9947 | 9.9000 | AID1781513 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0000 | 0.5376 | 9.9000 | AID1781513 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0005 | 0.9413 | 9.9000 | AID1781513 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0007 | 0.9610 | 10.0000 | AID1781513 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1656944 | Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability | |||
| AID1177036 | Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1781513 | Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate incubated for 20 mins by fluorometric assay | 2021 | Journal of natural products, 09-24, Volume: 84, Issue:9 | Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from |
| AID1177038 | Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177041 | Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1656939 | Inhibition of mushroom tyrosinase using L-DOPA as substrate | |||
| AID1656941 | Cytotoxicity against human A2058 cells assessed as reduction in cell viability | |||
| AID1656940 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | |||
| AID1656943 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability | |||
| AID1177037 | Cytotoxicity against human U2OS cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177040 | Cytotoxicity against human LO2 cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1177039 | Cytotoxicity against human HeLa cells after 96 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. |
| AID1656942 | Cytotoxicity against human A549 cells assessed as reduction in cell viability | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.07) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||