4'-demethyldesoxypodophyllotoxin profile

4'-demethyldesoxypodophyllotoxin: from the root of Bursera tonkinensis Guillaum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

4'-demethyldeoxypodophyllotoxin : A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 4-hydroxy-3,5-dimethoxyphenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Bursera tonkinensis	species	[no description available]	Burseraceae	A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. They are resinous trees and shrubs with alternate leaves composed of many leaflets.[MeSH]

ID Source	ID
PubMed CID	160705
CHEMBL ID	89905
CHEBI ID	1729
SCHEMBL ID	15892698
MeSH ID	M0495244

Synonym
CHEMBL89905
4-demethyl-deoxypodophyllotoxin
chebi:1729 ,
4'-demethyl-
NSC267714 ,
furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r-(5-alpha,5a-beta,8a-alpha))-
4'-demethyldesoxypodophyllotoxin
a 80198
3590-93-0
(5r,5ar,8ar)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one
4'-demethyldeoxypodophyllotoxin
(-)-4'-demethyldeoxypodophyllotoxin
NCGC00161920-01
(5r,5ar,8ar)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
AKOS004120062
podophyllotoxin, 4'-o-demethyl-4-deoxy-
(-)-4'-desmethyl-deoxypodophyllotoxin
4'-desmethyldesoxypodophyllotoxin
(5r,5ar,8ar)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydro-2h-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one
SCHEMBL15892698
DTXSID50189475
(5r,5ar,8ar)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5ah-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one, aldrichcpr
(-)-4'-demethyl-deoxypodophyllotoxin
(10r,11r,15r)-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-12-one
4-demethyldeoxypodophyllotoxin
Q27105498
7-dehydroxy-4-demethylpodophyllotoxin
HY-N10829
CS-0637021

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
immunosuppressive agent	An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
antioxidant	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
lignan	Any phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e".
gamma-lactone	A lactone having a five-membered lactone ring.
furonaphthodioxole
methoxybenzenes	Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.
phenols	Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
(-)-4'-demethyl-epipodophyllotoxin biosynthesis	1	11

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
TDP1 protein	Homo sapiens (human)	Potency	0.0512	0.0008	11.3822	44.6684	AID686978; AID686979
67.9K protein	Vaccinia virus	Potency	10.6101	0.0001	8.4406	100.0000	AID720579; AID720580
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	9.2000	0.0041	9.9848	25.9290	AID504444
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	2.5119	0.0200	10.7869	31.6228	AID942
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tubulin beta-4A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin beta chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	2.0529	10.0000	AID214688
Tubulin alpha-3C chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin alpha-1B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin alpha-4A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin beta-4B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin beta-3 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.8945	10.0000	AID214688
Tubulin beta-2A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin beta-8 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin alpha-3E chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin alpha-1A chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin alpha-1C chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9555	10.0000	AID214688
Tubulin beta-6 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin beta-2B chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9680	10.0000	AID214688
Tubulin beta-1 chain	Homo sapiens (human)	IC50 (µMol)	2.0000	0.0005	1.9870	10.0000	AID214688
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of microtubule polymerization	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4A chain	Homo sapiens (human)
odontoblast differentiation	Tubulin beta chain	Homo sapiens (human)
microtubule-based process	Tubulin beta chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin beta chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta chain	Homo sapiens (human)
regulation of synapse organization	Tubulin beta chain	Homo sapiens (human)
spindle assembly	Tubulin beta chain	Homo sapiens (human)
cell division	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1B chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1B chain	Homo sapiens (human)
cell division	Tubulin alpha-1B chain	Homo sapiens (human)
cellular response to interleukin-4	Tubulin alpha-1B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-4A chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta-4B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-3 chain	Homo sapiens (human)
axon guidance	Tubulin beta-3 chain	Homo sapiens (human)
netrin-activated signaling pathway	Tubulin beta-3 chain	Homo sapiens (human)
dorsal root ganglion development	Tubulin beta-3 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-3 chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2A chain	Homo sapiens (human)
oocyte maturation	Tubulin beta-8 chain	Homo sapiens (human)
spindle assembly involved in female meiosis	Tubulin beta-8 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-8 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-8 chain	Homo sapiens (human)
biological_process	Tubulin alpha-3E chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3E chain	Homo sapiens (human)
neuron migration	Tubulin alpha-1A chain	Homo sapiens (human)
startle response	Tubulin alpha-1A chain	Homo sapiens (human)
intracellular protein transport	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1A chain	Homo sapiens (human)
centrosome cycle	Tubulin alpha-1A chain	Homo sapiens (human)
smoothened signaling pathway	Tubulin alpha-1A chain	Homo sapiens (human)
memory	Tubulin alpha-1A chain	Homo sapiens (human)
adult locomotory behavior	Tubulin alpha-1A chain	Homo sapiens (human)
visual learning	Tubulin alpha-1A chain	Homo sapiens (human)
response to mechanical stimulus	Tubulin alpha-1A chain	Homo sapiens (human)
glial cell differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
gene expression	Tubulin alpha-1A chain	Homo sapiens (human)
dentate gyrus development	Tubulin alpha-1A chain	Homo sapiens (human)
cerebellar cortex morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
pyramidal neuron differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
cerebral cortex development	Tubulin alpha-1A chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1A chain	Homo sapiens (human)
response to tumor necrosis factor	Tubulin alpha-1A chain	Homo sapiens (human)
locomotory exploration behavior	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule polymerization	Tubulin alpha-1A chain	Homo sapiens (human)
forebrain morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
homeostasis of number of cells within a tissue	Tubulin alpha-1A chain	Homo sapiens (human)
regulation of synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
cell division	Tubulin alpha-1A chain	Homo sapiens (human)
neuron apoptotic process	Tubulin alpha-1A chain	Homo sapiens (human)
motor behavior	Tubulin alpha-1A chain	Homo sapiens (human)
cellular response to calcium ion	Tubulin alpha-1A chain	Homo sapiens (human)
organelle transport along microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
neuron projection arborization	Tubulin alpha-1A chain	Homo sapiens (human)
response to L-glutamate	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1C chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1C chain	Homo sapiens (human)
cell division	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-6 chain	Homo sapiens (human)
neuron migration	Tubulin beta-2B chain	Homo sapiens (human)
microtubule-based process	Tubulin beta-2B chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2B chain	Homo sapiens (human)
modulation of chemical synaptic transmission	Tubulin beta-2B chain	Homo sapiens (human)
positive regulation of axon guidance	Tubulin beta-2B chain	Homo sapiens (human)
embryonic brain development	Tubulin beta-2B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2B chain	Homo sapiens (human)
platelet formation	Tubulin beta-1 chain	Homo sapiens (human)
thyroid gland development	Tubulin beta-1 chain	Homo sapiens (human)
microtubule polymerization	Tubulin beta-1 chain	Homo sapiens (human)
spindle assembly	Tubulin beta-1 chain	Homo sapiens (human)
thyroid hormone transport	Tubulin beta-1 chain	Homo sapiens (human)
platelet aggregation	Tubulin beta-1 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
GTPase activity	Tubulin beta-4A chain	Homo sapiens (human)
calcium ion binding	Tubulin beta-4A chain	Homo sapiens (human)
protein binding	Tubulin beta-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
GTP binding	Tubulin beta-4A chain	Homo sapiens (human)
GTPase activity	Tubulin beta chain	Homo sapiens (human)
structural molecule activity	Tubulin beta chain	Homo sapiens (human)
protein binding	Tubulin beta chain	Homo sapiens (human)
protein domain specific binding	Tubulin beta chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin beta chain	Homo sapiens (human)
GTPase activating protein binding	Tubulin beta chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta chain	Homo sapiens (human)
protein-containing complex binding	Tubulin beta chain	Homo sapiens (human)
metal ion binding	Tubulin beta chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta chain	Homo sapiens (human)
GTP binding	Tubulin beta chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3C chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTPase activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1B chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-4A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-4A chain	Homo sapiens (human)
protein kinase binding	Tubulin alpha-4A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-4A chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-4B chain	Homo sapiens (human)
protein binding	Tubulin beta-4B chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta-4B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-4B chain	Homo sapiens (human)
unfolded protein binding	Tubulin beta-4B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
GTP binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-3 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
protein binding	Tubulin beta-3 chain	Homo sapiens (human)
GTP binding	Tubulin beta-3 chain	Homo sapiens (human)
peptide binding	Tubulin beta-3 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-3 chain	Homo sapiens (human)
netrin receptor binding	Tubulin beta-3 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2A chain	Homo sapiens (human)
protein binding	Tubulin beta-2A chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
GTP binding	Tubulin beta-2A chain	Homo sapiens (human)
molecular_function	Tubulin beta-8 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-8 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-8 chain	Homo sapiens (human)
GTP binding	Tubulin beta-8 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
molecular_function	Tubulin alpha-3E chain	Homo sapiens (human)
protein binding	Tubulin alpha-3E chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3E chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1A chain	Homo sapiens (human)
protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1A chain	Homo sapiens (human)
identical protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein-containing complex binding	Tubulin alpha-1A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin alpha-1A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1C chain	Homo sapiens (human)
protein binding	Tubulin alpha-1C chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
molecular_function	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-6 chain	Homo sapiens (human)
protein binding	Tubulin beta-6 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-6 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
GTP binding	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2B chain	Homo sapiens (human)
protein binding	Tubulin beta-2B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2B chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin beta-2B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
GTP binding	Tubulin beta-2B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-1 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-1 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
GTP binding	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Tubulin beta-4A chain	Homo sapiens (human)
cytosol	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
axoneme	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
internode region of axon	Tubulin beta-4A chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-4A chain	Homo sapiens (human)
myelin sheath	Tubulin beta-4A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin beta chain	Homo sapiens (human)
nuclear envelope lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
cytosol	Tubulin beta chain	Homo sapiens (human)
cytoskeleton	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin beta chain	Homo sapiens (human)
cell body	Tubulin beta chain	Homo sapiens (human)
membrane raft	Tubulin beta chain	Homo sapiens (human)
intercellular bridge	Tubulin beta chain	Homo sapiens (human)
extracellular exosome	Tubulin beta chain	Homo sapiens (human)
mitotic spindle	Tubulin beta chain	Homo sapiens (human)
protein-containing complex	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule	Tubulin alpha-3C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1B chain	Homo sapiens (human)
extracellular region	Tubulin alpha-4A chain	Homo sapiens (human)
cytosol	Tubulin alpha-4A chain	Homo sapiens (human)
cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-4A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta-4B chain	Homo sapiens (human)
nucleus	Tubulin beta-4B chain	Homo sapiens (human)
cytosol	Tubulin beta-4B chain	Homo sapiens (human)
cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
axonemal microtubule	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta-4B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4B chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4B chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
lamellipodium	Tubulin beta-3 chain	Homo sapiens (human)
filopodium	Tubulin beta-3 chain	Homo sapiens (human)
axon	Tubulin beta-3 chain	Homo sapiens (human)
dendrite	Tubulin beta-3 chain	Homo sapiens (human)
growth cone	Tubulin beta-3 chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-3 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-3 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-3 chain	Homo sapiens (human)
cell periphery	Tubulin beta-3 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-2A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2A chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-2A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-8 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-8 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
meiotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
microtubule	Tubulin beta-8 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-8 chain	Homo sapiens (human)
nucleus	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule	Tubulin alpha-3E chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3E chain	Homo sapiens (human)
condensed chromosome	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1A chain	Homo sapiens (human)
cytosol	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
axonemal microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
plasma membrane	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
neuromuscular junction	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin alpha-1A chain	Homo sapiens (human)
recycling endosome	Tubulin alpha-1A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
vesicle	Tubulin alpha-1C chain	Homo sapiens (human)
membrane raft	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1C chain	Homo sapiens (human)
nucleus	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-6 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-6 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-6 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
nucleus	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2B chain	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-1 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-1 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule	Tubulin beta-1 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (73)

Assay ID	Title	Year	Journal	Article
AID335778	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.00128 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID1286947	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
AID335785	Cytotoxicity against human Lu1 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID1091875	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as inhibition of larval pupation at 1 mg/ml treated for 3 secs before larval infestation on corn leaves by leaf-dipping me	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID477033	Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method	2010	European journal of medicinal chemistry, Apr, Volume: 45, Issue:4	First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
AID633358	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24	Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
AID1091878	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as reduction in larval movement at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 24 h	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID1286946	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
AID335783	Cytotoxicity against human KBV1 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335777	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.0064 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID615937	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
AID140793	Compound was tested for Cytotoxic activity by lymphocyte viability assay.	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Immunosuppressive cyclolignans.
AID615936	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
AID57233	Inhibition of DNA topoisomerase II in S180 (murine sarcoma) cells.	2003	Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16	Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
AID477034	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method	2010	European journal of medicinal chemistry, Apr, Volume: 45, Issue:4	First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
AID598808	Cytotoxicity against human KB cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12	Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
AID335774	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.8 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID644047	Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay	2012	European journal of medicinal chemistry, Mar, Volume: 49	Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
AID644046	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2012	European journal of medicinal chemistry, Mar, Volume: 49	Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
AID103429	In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line.	2002	Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23	Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
AID335773	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 4 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335776	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.032 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335788	Cytotoxicity against human KB cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335781	Cytotoxicity against human Col2 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID633360	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay	2011	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24	Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
AID1286949	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
AID335782	Cytotoxicity against human HT cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID133404	Antitumor activity against Lewis lung carcinoma (LLC) cells transplanted s.c. into the auxiliary region of the BDF1 mice at a formulable dose of 0.06 mmol/kg/day	2002	Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23	Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
AID1091873	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of molting to abnormal pupae at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID633362	Octanol-water partition coefficient, log P of the compound	2011	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24	Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
AID335780	Cytotoxicity against human BC1 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID214688	Inhibition of tubulin polymerization in S180 (murine sarcoma) cells.	2003	Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16	Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
AID335784	Cytotoxicity against human LNCAP cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID8463	Cytotoxicity in A549 (human carcinoma) cell line.	2003	Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16	Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
AID477035	Antioxidant activity in Sprague-Dawley rat kidney assessed as lipid peroxidation by thiobarbituric acid assay	2010	European journal of medicinal chemistry, Apr, Volume: 45, Issue:4	First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
AID335771	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 100 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335775	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.16 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID616014	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	2011	European journal of medicinal chemistry, Sep, Volume: 46, Issue:9	Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.
AID335769	Toxicity in brine shrimp	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335772	Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 20 ug/mL	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID202808	Cytotoxicity in SK-MEL-2 (human melanoma) cell line.	2003	Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16	Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
AID1286948	Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
AID1091879	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 30 days	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID477032	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2010	European journal of medicinal chemistry, Apr, Volume: 45, Issue:4	First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
AID277523	Cytotoxicity against androgen-independent human PC3 cells	2007	Journal of natural products, Feb, Volume: 70, Issue:2	Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.
AID633361	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay	2011	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24	Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
AID335786	Cytotoxicity against human U373 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID198970	Cytotoxicity in S-180 (murine sarcoma) cell was determined.	2003	Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16	Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
AID335787	Cytotoxicity against human ZR-75-1 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID335779	Cytotoxicity against human A431 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID1091876	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of loss of body liquid at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID201787	In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line.	2002	Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23	Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
AID221407	Compound was tested for Immunosuppression activity by mixed lymphocyte reaction (MLR) in murine splenocytes of mice	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Immunosuppressive cyclolignans.
AID337695	Antibacterial activity against Escherichia coli ATCC 25922 at 5 ug after 48 hrs by silica gel plate-based INT-formazan method
AID633359	Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24	Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
AID1286950	Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
AID1091877	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of larval immobility at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 48	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID1091880	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 20 days	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID1091874	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as inhibition of adult emergence at 1 mg/ml treated for 3 secs before larval infestation on corn leaves by leaf-dipping me	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID277522	Cytotoxicity against androgen sensitive human LNCaP cells	2007	Journal of natural products, Feb, Volume: 70, Issue:2	Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.
AID644045	Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay	2012	European journal of medicinal chemistry, Mar, Volume: 49	Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
AID337694	Antibacterial activity against Bacillus subtilis ATCC 6633 at 5 ug after 48 hrs by silica gel plate-based INT-formazan method
AID644048	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	2012	European journal of medicinal chemistry, Mar, Volume: 49	Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
AID477036	Antioxidant activity in Sprague-Dawley rat liver assessed as lipid peroxidation by thiobarbituric acid assay	2010	European journal of medicinal chemistry, Apr, Volume: 45, Issue:4	First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
AID335789	Antimicrobial activity against Candida albicans ATCC 10231 at 0.2 to 1 ug/ml	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID1091881	In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 10 days	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
AID235867	Non cytotoxic IM activity index which is the ratio of IC50 of LcV to IC50 of MLR	1996	Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14	Immunosuppressive cyclolignans.
AID8459	In vitro cytotoxicity against A549 (human lung carcinoma) cell line.	2002	Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23	Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
AID598807	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12	Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
AID335770	Cytotoxicity in mouse P388 cells	1993	Journal of natural products, Oct, Volume: 56, Issue:10	Cytotoxic constituents from Hyptis verticillata.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (13.33)	18.2507
2000's	5 (33.33)	29.6817
2010's	7 (46.67)	24.3611
2020's	1 (6.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzene [no description available]	2.05	1	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
carbamates [no description available]	2.06	1	amino-acid anion
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.5	2	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
vincristine [no description available]	1.98	1	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	1.98	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	3.53	8	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
vinblastine [no description available]	1.98	1
etoposide [no description available]	3.44	7	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
beta-peltatin beta-peltatin : An organic heterotetracyclic compound that is alpha-peltatin in which the phenolic hydroxy group of the 4-hydroxy-3,5-dimethoxyphenyl substitutent had been converted into the corresponding methyl ether.	1.99	1	furonaphthodioxole; gamma-lactone; lignan; organic heterotetracyclic compound; phenols	antineoplastic agent; plant metabolite
alpha-peltatin alpha-peltatin: RN given for (5R-(5alpha,5beta,8aalpha))-isomer. alpha-peltatin : An organic heterotetracyclic compound that is 4'-demethylpodophyllotoxin which is substituted by a hydroxy group at position 10 but which is lacking the hydroxy group at position 9. It is found as a glucoside in the rhizomes of Podophyllum peltatum.	1.99	1	furonaphthodioxole; gamma-lactone; lignan; organic heterotetracyclic compound; phenols	antineoplastic agent; metabolite
diphyllin diphyllin: extract of Cleistanthus collinus (Roxb), a highly poisonous plant; do not confuse with diphyllin or diphylline which is the main heading AMINOPHYLLINE; do not confuse with the theophylline derivative DYPHYLLINE	2.03	1	lignan
epipodophyllotoxin [no description available]	1.99	1
4'-demethylpodophyllotoxin 4'-demethylpodophyllotoxin : An organic heterotetracyclic compound that is podophyllotoxin in which the methyl ether group at position 4 of the trimethoxyphenyl group has been cleaved to afford the corresponding phenol.	2.45	2	furonaphthodioxole; organic heterotetracyclic compound; phenols	metabolite
prostaglandins b Prostaglandins B: Physiologically active prostaglandins found in many tissues and organs. They are potent pressor substances and have many other physiological activities.	2.06	1
anthricin anthricin: antitumor constituent from Anthriscus sylvestris (L.) Hoffm; structure in first source. deoxypodophyllotoxin : A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.	3.64	9	furonaphthodioxole; gamma-lactone; lignan; methoxybenzenes	antineoplastic agent; apoptosis inducer; plant metabolite
yatein yatein: isolated from Anthriscus sylvestris; structure in first source. dihydroanhydropodorhizol : A member of the class of butan-4-olides carrying 3,4,5-trimethoxybenzyl and (1,3-benzodioxol-5-yl)methyl substituents at positions 3 and 4 respectively.	1.98	1	benzodioxoles; butan-4-olide; lignan; methoxybenzenes	plant metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.02	1
maytansine Maytansine: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.. maytansine : An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.	1.98	1	alpha-amino acid ester; carbamate ester; epoxide; maytansinoid; organic heterotetracyclic compound; organochlorine compound	antimicrobial agent; antimitotic; antineoplastic agent; plant metabolite; tubulin modulator
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	1.99	1	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
toosendanin [no description available]	2.05	1	limonoid

Condition	Relationship Strength	Studies
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.98	1
Cancer of Prostate [description not available]	2.03	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.03	1
Benign Neoplasms [description not available]	2.07	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.07	1

4'-demethyldesoxypodophyllotoxin

Description

Cross-References

Synonyms (29)

Roles (4)

Drug Classes (5)

Pathways (1)

Protein Targets (19)

Potency Measurements

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (73)

Research

Studies (15)

Market Indicators

Research Demand Index: 12.00

Study Types

4'-demethyldesoxypodophyllotoxin

Description

Related Flora

Cross-References

Synonyms (29)

Roles (4)

Drug Classes (5)

Pathways (1)

Protein Targets (19)

Potency Measurements

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (73)

Research

Studies (15)

Market Indicators

Research Demand Index: 12.00

Study Types

Related Drugs (20)

Related Conditions (5)