sophoflavescenol: a prenylated flavonol from the roots of Sophora flavescens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Sophora | genus | A plant genus of the family FABACEAE.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 9929189 |
| CHEMBL ID | 77651 |
| SCHEMBL ID | 14563970 |
| MeSH ID | M0301028 |
| Synonym |
|---|
| 3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)chromen-4-one |
| CHEMBL77651 , |
| 3,7-dihydroxy-2-(4-hydroxy-phenyl)-5-methoxy-8-(3-methyl-but-2-enyl)-chromen-4-one |
| bdbm50116711 |
| 3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)-4h-chromen-4-one |
| sophoflavescenol |
| LMPK12112538 |
| SCHEMBL14563970 |
| 216450-65-6 |
| HY-N2284 |
| CS-6033 |
| AKOS032945037 |
| BCP24815 |
| FT-0775537 |
| MS-25898 |
| 3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)-4h-chromen-4-one |
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| visual perception | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Bos taurus (cattle) |
| visual perception | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Bos taurus (cattle) |
| visual perception | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Bos taurus (cattle) |
| visual perception | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Bos taurus (cattle) |
| entrainment of circadian clock by photoperiod | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Bos taurus (cattle) |
| visual perception | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID426770 | Inhibition of rat diaphragm PDE5 | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6. |
| AID403550 | Antiviral activity against HSV2 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay | 1998 | Journal of natural products, Dec, Volume: 61, Issue:12 | A new prenylated flavonol from the roots of Sophora flavescens. |
| AID159374 | Relative inhibition of Phosphodiesterase 3 and Phosphodiesterase 5 | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID159373 | Inhibition of Phosphodiesterase 3 from rat diaphragm | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID160105 | Inhibition of Phosphodiesterase 4 from rat liver | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID160123 | Relative inhibition of Phosphodiesterase 4 and Phosphodiesterase 5 | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID158109 | Inhibition of Phosphodiesterase 5 from rat diaphragm | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID158110 | Inhibition of Phosphodiesterase 5 from rat diaphragm | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. |
| AID403549 | Antiviral activity against HSV1 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay | 1998 | Journal of natural products, Dec, Volume: 61, Issue:12 | A new prenylated flavonol from the roots of Sophora flavescens. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.30) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||