Page last updated: 2024-12-07
acetoxyestrone
Description
Acetoxyestrone is a synthetic estrogen that is a derivative of estrone. It has been studied as a potential treatment for breast cancer, as it has been shown to inhibit the growth of breast cancer cells in vitro and in vivo. Acetoxyestrone is also being investigated as a potential treatment for other conditions, such as osteoporosis and Alzheimer's disease. It is synthesized by the acetylation of estrone, which is a naturally occurring steroid hormone produced by the ovaries. The mechanism of action of acetoxyestrone is thought to be related to its ability to bind to estrogen receptors, which are found in a variety of tissues, including the breast, uterus, and brain. Acetoxyestrone has also been shown to have anti-inflammatory and antioxidant effects. The compound is studied because of its potential as a therapeutic agent for a variety of conditions. Studies continue to be conducted to further evaluate its efficacy and safety. '
puboestrene: from the bark of Holarrhena pubescens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 92846 |
| CHEMBL ID | 1627997 |
| SCHEMBL ID | 603954 |
| MeSH ID | M0063864 |
Synonyms (33)
| Synonym |
|---|
| estra-1,3,5(10)-trien-17-one, 3-(acetyloxy)- |
| estrone acetate |
| 901-93-9 |
| 1,3,5[10]-estratrien-3-ol-17-one acetate |
| 3-acetoxyestrone |
| hogival |
| [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] acetate |
| CHEMBL1627997 , |
| acetoxyestrone |
| unii-4l6usg266b |
| 4l6usg266b , |
| bdbm50370422 |
| SS-4431 |
| 3-o-acetylestrone |
| 3-acetylestrone |
| oestrone-3-acetate |
| estrone acetate [who-dd] |
| estrone acetate [mi] |
| estrone 3-acetate |
| puboestrene |
| acetylestrone |
| SCHEMBL603954 |
| 17-oxo-1,3,5(10)-estratrien-3-yl acetate |
| AKOS024374937 |
| 3-acetoxyestrone r |
| 3-hydroxyestra-1,3,5(10)-17-one acetate |
| 17-oxoestra-1(10),2,4-trien-3-yl acetate # |
| 3beta-acetoxyestra-1,3,5(10)-trien-17-one |
| 3-acetoxy-17-oxo-estra-1,3,5(10)-triene |
| (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yl acetate |
| estroneacetate |
| Q27259970 |
| DTXSID801009160 |
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|
| Steryl-sulfatase | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0001 | 0.4071 | 7.6000 | AID240903 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Biological Processes (3)
Molecular Functions (4)
Ceullar Components (9)
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.56
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.56 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.51 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |