| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID327103 | Inhibition of PIK-PKB-mTOR pathway in human PC3M cells | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327111 | Inhibition of CYP2E1 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457289 | Inhibition of PKCgamma at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327102 | Selectivity for PKBbeta over p70S6K | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327107 | Inhibition of CYP1A2 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457301 | Inhibition of CYP2C19 in human microsomal preparation | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327116 | Tmax in BALB/c mouse at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327109 | Inhibition of CYP2C19 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327115 | Half life in BALB/c mouse at 25 mg/kg, po | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457300 | Inhibition of CYP2C9 in human microsomal preparation | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327124 | Inhibition of p70S6K by radiometric filter binding assay | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457046 | Inhibition of PKBbeta by radiometric filter binding assay | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327108 | Inhibition of CYP2A6 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457047 | Inhibition of PKA by radiometric filter binding assay | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457278 | Inhibition of EGFR at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457274 | Inhibition of CDK2/Cyclin A at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457271 | Inhibition of PKA at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457291 | Inhibition of SGK1 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457287 | Inhibition of PKCalpha at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457270 | Inhibition of PKB at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID1623258 | Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Recent advances in the discovery of small molecules targeting glioblastoma. |
| AID327090 | Inhibition of GSK3-beta in human PC3M cells by ELISA | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327120 | AUC in BALB/c mouse at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457280 | Inhibition of FLT3 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457304 | Plasma clearance in mouse at 25 mg/kg, iv | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457292 | Inhibition of SRC at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457283 | Inhibition of JAK3 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457302 | Half life in mouse at 25 mg/kg, iv | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457272 | Inhibition of ROCK2 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327123 | Clearance in BALB/c mouse plasma at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457285 | Inhibition of ERK2 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327112 | Inhibition of CYP2C9 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457275 | Inhibition of CHK1 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457297 | Inhibition of CYP1A2 in human microsomal preparation | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457296 | Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457284 | Inhibition of KDR at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327105 | Metabolic stability in human liver microsomes at 10 uM after 30 mins | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327089 | Growth inhibition of human PC3M cells by SRB assay | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327118 | Cmax in BALB/c mouse at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457048 | Selectivity ratio of IC50 for PKA to IC50 for PKBbeta | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327088 | Inhibition of recombinant catalytic subunit PKA by radiometric filter binding assay | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457293 | Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457288 | Inhibition of PKCdelta at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457276 | Inhibition of CHK2 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327121 | AUC in BALB/c mouse at 25 mg/kg, po | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457290 | Inhibition of RSK2 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457299 | Inhibition of CYP3A4 in human microsomal preparation | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327104 | Inhibition of PIK-PKB-mTOR pathway in human U87MG cells | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457305 | Oral bioavailability in mouse at 25 mg/kg | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457282 | Inhibition of IGF1R at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457281 | Inhibition of GSK3-beta at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327126 | Drug level in BALB/c mouse plasma at 25 mg/kg, po | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457298 | Inhibition of CYP2D6 in human microsomal preparation | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327092 | Growth inhibition of human U87MG cells by SRB assay | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327106 | Metabolic stability in BALB/c mouse liver microsomes at 10 uM after 30 mins | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457294 | Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISA | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327125 | Oral bioavailability in BALB/c mouse at 25 mg/kg | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457303 | Volume of distribution at steady state in mouse at 25 mg/kg, iv | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327122 | Volume of distribution at steady state in BALB/c mouse at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457286 | Inhibition of MAPKAPK2 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327117 | Tmax in BALB/c mouse at 25 mg/kg, po | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457295 | Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327087 | Inhibition of PKBbeta recombinant by radiometric filter binding assay | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327091 | Inhibition of GSK3-beta in human U87MG cells by ELISA | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457279 | Inhibition of FGFR1 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327114 | Half life in BALB/c mouse at 25 mg/kg, iv | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457315 | Solubility in aqueous buffer at pH 7.0 | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457273 | Inhibition of P70S6K at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID457314 | Solubility in aqueous buffer at pH 6.5 | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID327110 | Inhibition of CYP3A4 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327113 | Inhibition of CYP2D6 | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID327119 | Cmax in BALB/c mouse at 25 mg/kg, po | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. |
| AID457277 | Inhibition of CK2alpha1 at 1 uM | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1801131 | KinEASE Assay from Article 10.1021/cb500355c: \\Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors.\\ | 2015 | ACS chemical biology, Jan-16, Volume: 10, Issue:1
| Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |