| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1498592 | Inhibition of P-gp in human MCF7/ADR cells assessed as increase in intracellular Rh123 accumulation at 24 uM after 2 hrs by flow cytometry | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1102113 | Antifungal activity against Colletotrichum gloeosporioides assessed as growth inhibition at 300 uM after 48 hr by microplate photometric analysis | 2003 | Journal of agricultural and food chemistry, Feb-12, Volume: 51, Issue:4
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. |
| AID1102097 | Antifungal activity against Diaporthe ampelina assessed as growth inhibition at 30 uM after 120 hr by microplate photometric analysis | 2003 | Journal of agricultural and food chemistry, Feb-12, Volume: 51, Issue:4
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. |
| AID99820 | Blockade of peak steady-state K+ currents of Kv1.3 channels in mice fibroblasts L929 at 50 uM concentration | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID1498580 | Growth inhibition of human MDA-MB-231/ADR cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498581 | Resistance factor, ratio of IC50 for human MDA-MB-231/ADR cells to IC50 for human MDA-MB-231 cells | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498584 | Induction of apoptosis in human MCF7 cells at 24 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498586 | Induction of apoptosis in human MCF7/ADR cells at 12 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1102102 | Antifungal activity against Phomopsis obscurans assessed as growth inhibition at 30 uM after 120 hr by microplate photometric analysis | 2003 | Journal of agricultural and food chemistry, Feb-12, Volume: 51, Issue:4
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. |
| AID1102100 | Antifungal activity against Phomopsis obscurans assessed as growth inhibition at 300 uM after 120 hr by microplate photometric analysis | 2003 | Journal of agricultural and food chemistry, Feb-12, Volume: 51, Issue:4
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. |
| AID1498585 | Induction of apoptosis in human MCF7/ADR cells at 6 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID144216 | Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 50 uM concentration | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID436153 | Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11
| Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. |
| AID1498582 | Induction of apoptosis in human MCF7 cells at 6 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498596 | Displacement of [3H]colchicine from tubulin (unknown origin) at 5 uM after 10 mins relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID217464 | Inhibition of N1E-115 cells Kv channels | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID1498578 | Resistance factor, ratio of IC50 for human MCF7/ADR cells to IC50 for human MCF7 cells | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID436154 | Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of zymosan-activated oxidative burst by chemiluminescence assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11
| Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. |
| AID357622 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 100 ug/mL pre-incubated 3 mins before collagen challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID1498587 | Induction of apoptosis in human MCF7/ADR cells at 24 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID357626 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of platelet activating factor-induced platelet aggregation at 50 ug/mL preincubated 3 mins before PAF challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID357617 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 ug/mL pre-incubated 3 mins before arachidonic acid challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID1498576 | Growth inhibition of human MCF7 cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1102115 | Antifungal activity against Colletotrichum fragariae assessed as growth inhibition at 30 to 300 uM after 48 hr by microplate photometric analysis | 2003 | Journal of agricultural and food chemistry, Feb-12, Volume: 51, Issue:4
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. |
| AID1498595 | Displacement of [3H]colchicine from tubulin (unknown origin) at 1 uM after 10 mins relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498579 | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID436155 | Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of PMA-activated oxidative burst by chemiluminescence assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11
| Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. |
| AID217635 | Selectivity (S) of Kv1.3 subunit blockade over N1E-115 Kv channel blockade given by IC50(N1E-115)/IC50(KV1.3) | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID1498583 | Induction of apoptosis in human MCF7 cells at 12 uM after 24 hrs by Annexin V-FITC/PI double staining based flow cytometry relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID144222 | Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 50 uM concentration | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID357623 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 50 ug/mL pre-incubated 3 mins before collagen challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID217633 | Blockade of peak steady-state K+ currents of voltage-gated potassium channel subunit Kv1.3 in mouse fibroblasts L929 at 50 uM | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
| Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
| AID1498591 | Downregulation of P-gp protein expression level in human MCF7 cells assessed as P-gp protein level up to 24 uM by Western blot analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID357618 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 50 ug/mL preincubated 3 mins before arachidonic acid challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID1755695 | Inhibition of GST-tagged recombinant RANKL/M-CSF-induced osteoclastogenesis in C57BL/6 mouse bone marrow derived macrophages assessed as TRAcP enzymatic activity incubated for 5 days with subsequent replenishment of media for 2 days and measured by leucoc | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Deep learning enables discovery of highly potent anti-osteoporosis natural products. |
| AID1498590 | Downregulation of P-gp mRNA level in human MCF7/ADR cells by qRT-PCR analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498588 | Downregulation of P-gp protein expression level in human MCF7/ADR cells assessed as P-gp protein level up to 24 uM by Western blot analysis (Rvb = 0.67 No_unit) | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498597 | Inhibition of porcine MAP-rich tubulin polymerization measured every 30 secs for 30 mins | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID355720 | Cytotoxicity against human A2780 cells | 2003 | Journal of natural products, Apr, Volume: 66, Issue:4
| New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest. |
| AID1498577 | Growth inhibition of human MCF7/ADR cells after 48 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID357625 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of platelet activating factor-induced platelet aggregation at 100 ug/mL pre-incubated 3 mins before PAF challenge by turbidimetric method | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. |
| AID436152 | Immunomodulatory activity in whole blood assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11
| Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. |
| AID1498594 | Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidimetric analysis | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| AID1498589 | Downregulation of P-gp expression level in human MCF7/ADR cells assessed as P-gp mRNA level up to 24 uM by qRT-PCR analysis (Rvb = 17.5 No_unit) | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |