| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1679177 | Lipophilicity, log D of compound at pH 7.4 | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679861 | Inhibition of GLK (unknown origin) transfected in human 293T cells co-transfected with GFP-fused PKCtheta assessed as reduction in PKCtheta phosphorylation by ELISA | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10
| Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity. |
| AID1679152 | Cytotoxicity against human U20S cells harboring AZ MTH1 siRNA assessed as cell viability measured after 2 days by crystal violet staining based cell counting analysis relative to control | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679154 | Cytotoxicity against MTH1 knockout human SW480 cells assessed as cell viability measured after 7 day by Cell-titer glo luciferase assay relative to control | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679180 | Cytotoxicity against human U20S cells harboring siRNA assessed as cell viability measured after 2 days by crystal violet staining based cell counting analysis relative to control | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679862 | Inhibition of GLK (unknown origin) by alphascreen assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10
| Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity. |
| AID1679162 | Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679165 | Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation half life by surface plasmon resonance analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1542231 | Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate measured after 30 mins by malachite green dye based inorganic phosphatase coupled absorbance | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. |
| AID1337190 | Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate preincubated with protein followed by substrate addition measured over 15 mins by luminescence-based assay | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID1679163 | Antiproliferative activity against human U2OS cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679151 | Cytotoxicity against human U20S cells harboring MTH1 siRNA assessed as cell viability measured after 2 days by crystal violet staining based cell counting analysis relative to control | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1337191 | Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 2-OH-dATP as substrate preincubated with protein followed by substrate addition measured over 15 mins by luminescence-based assay | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID1547865 | Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins followed by substrate addition and measured after 3 hrs by PPiLight Inorganic Pyrophosphate assay kit method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3
| Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. |
| AID1679160 | Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 7 days by Hoechst 33342 dye based cell counting analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1547864 | Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins followed by substrate addition and measured after 15 mins by PPiLight Inorganic Pyrophosphate assay kit meth | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3
| Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. |
| AID1293607 | Inhibition of recombinant human MTH1 expressed in Escherichia coli BL21 DE3 cells preincubated for 15 mins followed by 8-oxo-dGTP substrate addition measured after 15 mins by luminescence based assay | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| MutT Homolog 1 (MTH1): The Silencing of a Target. |
| AID1679179 | Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins by PPiLight detection reagent based luminescence assay | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1337143 | Binding affinity to ALK (unknown origin) | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID1551935 | Antiproliferative activity against human IMR32 cells by sulforhodamine B assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Targeting tropomyosin receptor kinase for cancer therapy. |
| AID1337142 | Binding affinity to MET (unknown origin) | 2017 | Nature reviews. Drug discovery, Jun, Volume: 16, Issue:6
| Non-kinase targets of protein kinase inhibitors. |
| AID1679164 | Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins by CETSA-based Western blot analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID617229 | Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay | 2011 | Journal of medicinal chemistry, Sep-22, Volume: 54, Issue:18
| Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). |
| AID1547866 | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3
| Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. |
| AID1679161 | Antiproliferative activity against human NCI-H358 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679166 | Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| AID1679153 | Cytotoxicity against human SW480 cells assessed as cell viability measured after 7 day by Cell-titer glo luciferase assay relative to control | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
| Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |