Page last updated: 2024-10-14

ki 8751

Description

N-(2,4-difluorophenyl)-N'-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-fluorophenyl)urea: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11317348
CHEMBL ID	178455
CHEBI ID	92822
SCHEMBL ID	1249562
MeSH ID	M0483050

Synonyms (51)

Synonym
HY-12038
HMS3269O17
BRD-K47150025-001-01-2
NCGC00167768-01
1-(2,4-difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea
bdbm50162147
CHEMBL178455 ,
1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea
KI 8751 ,
BCP9000009
228559-41-9
KI8751 ,
BCP0726000123
NCGC00167768-02
CS-0190
n-(2,4-difluorophenyl)-n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
MLS006011284
smr004703034
SCHEMBL1249562
tert-butyl2-bromobutyrate
1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea
AC-30283
AKOS024457157
ki-8751
n-(2,4-difluorophenyl)-n'-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-fluorophenyl)urea
EX-A227
DTXSID60462145
1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea
CHEBI:92822
HMS3654B19
J-014880
mfcd09971092
SW218156-2
BCP02842
1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Q27164581
vegfr2 kinase inhibitor vi, ki8751 - cas 228559-41-9
n-(2,4-difluorophenyl)-n'-[4-[(6,7-dimethoxy-4-quinolin yl)oxy]-2-fluorophenyl]urea
S1363
FT-0704656
HMS3677F19
AS-19388
HMS3413F19
SB19355
CCG-269442
rp6ugt29ff ,
unii-rp6ugt29ff
urea, n-(2,4-difluorophenyl)-n'-(4-((6,7-dimethoxy-4-quinolinyl)oxy)-2-fluorophenyl)-
n-(2,4-difluorophenyl)-n'-(4-((6,7-dimethoxy-4-quinolinyl)oxy)-2-fluorophenyl)urea
1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl)urea
NCGC00167768-11

Bioavailability

Excerpt	Reference
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Fumarate hydratase	Homo sapiens (human)	Potency	37.2212	0.0030	8.7949	48.0869	AID1347053
PPM1D protein	Homo sapiens (human)	Potency	10.4353	0.0052	9.4661	32.9993	AID1347411
EWS/FLI fusion protein	Homo sapiens (human)	Potency	14.7485	0.0013	10.1577	42.8575	AID1259252; AID1259253; AID1259255; AID1259256
polyprotein	Zika virus	Potency	37.2212	0.0030	8.7949	48.0869	AID1347053
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	17.7828	0.0079	8.2332	1,122.0200	AID2546
Interferon beta	Homo sapiens (human)	Potency	10.4353	0.0033	9.1582	39.8107	AID1347411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Epidermal growth factor receptor	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0000	0.5369	10.0000	AID241262; AID241322
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0004	0.3722	10.0000	AID241358
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50 (µMol)	0.0400	0.0007	0.4708	10.0000	AID241626
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50 (µMol)	0.0670	0.0001	0.4912	10.0000	AID241725
Fibroblast growth factor receptor 2	Homo sapiens (human)	IC50 (µMol)	0.1700	0.0004	0.3276	8.6200	AID241407
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50 (µMol)	10.0000	0.0025	3.0926	9.5820	AID241264
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	IC50 (µMol)	2.4000	0.0003	0.3887	7.0000	AID1129405
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50 (µMol)	0.8016	0.0000	0.4830	8.8000	AID1129405; AID241663; AID241726
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50 (µMol)	2.4000	0.0003	0.7123	7.0700	AID1129405
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50 (µMol)	2.4000	0.0002	0.6603	10.0000	AID1129405
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (394)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
MAPK cascade	Epidermal growth factor receptor	Homo sapiens (human)
ossification	Epidermal growth factor receptor	Homo sapiens (human)
embryonic placenta development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
hair follicle development	Epidermal growth factor receptor	Homo sapiens (human)
translation	Epidermal growth factor receptor	Homo sapiens (human)
signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
activation of phospholipase C activity	Epidermal growth factor receptor	Homo sapiens (human)
salivary gland morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
midgut development	Epidermal growth factor receptor	Homo sapiens (human)
learning or memory	Epidermal growth factor receptor	Homo sapiens (human)
circadian rhythm	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
diterpenoid metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
cerebral cortex cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell growth	Epidermal growth factor receptor	Homo sapiens (human)
lung development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of superoxide anion generation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
response to cobalamin	Epidermal growth factor receptor	Homo sapiens (human)
response to hydroxyisoflavone	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to reactive oxygen species	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ERBB2-EGFR signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of protein catabolic process	Epidermal growth factor receptor	Homo sapiens (human)
vasodilation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ovulation cycle	Epidermal growth factor receptor	Homo sapiens (human)
hydrogen peroxide metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of apoptotic process	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of MAP kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
tongue development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA repair	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA replication	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of bone resorption	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of vasoconstriction	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Epidermal growth factor receptor	Homo sapiens (human)
regulation of JNK cascade	Epidermal growth factor receptor	Homo sapiens (human)
symbiont entry into host cell	Epidermal growth factor receptor	Homo sapiens (human)
protein autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
astrocyte activation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Epidermal growth factor receptor	Homo sapiens (human)
digestive tract morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
neuron projection morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
protein insertion into membrane	Epidermal growth factor receptor	Homo sapiens (human)
response to calcium ion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of glial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
morphogenesis of an epithelial fold	Epidermal growth factor receptor	Homo sapiens (human)
eyelid development in camera-type eye	Epidermal growth factor receptor	Homo sapiens (human)
response to UV-A	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of mucus secretion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to amino acid stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to mechanical stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to cadmium ion	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to xenobiotic stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to dexamethasone stimulus	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
liver regeneration	Epidermal growth factor receptor	Homo sapiens (human)
cell-cell adhesion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein kinase C activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of prolactin secretion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of miRNA transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of cardiocyte differentiation	Epidermal growth factor receptor	Homo sapiens (human)
neurogenesis	Epidermal growth factor receptor	Homo sapiens (human)
multicellular organism development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
endothelial cell morphogenesis	Hepatocyte growth factor receptor	Homo sapiens (human)
signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of autophagy	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of microtubule polymerization	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of Rho protein signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Hepatocyte growth factor receptor	Homo sapiens (human)
positive chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of stress fiber assembly	Hepatocyte growth factor receptor	Homo sapiens (human)
excitatory postsynaptic potential	Hepatocyte growth factor receptor	Homo sapiens (human)
establishment of skin barrier	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin-plexin signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of hydrogen peroxide-mediated programmed cell death	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of guanyl-nucleotide exchange factor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
liver development	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
phagocytosis	Hepatocyte growth factor receptor	Homo sapiens (human)
multicellular organism development	Hepatocyte growth factor receptor	Homo sapiens (human)
neuron differentiation	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
cell migration	Hepatocyte growth factor receptor	Homo sapiens (human)
pancreas development	Hepatocyte growth factor receptor	Homo sapiens (human)
nervous system development	Hepatocyte growth factor receptor	Homo sapiens (human)
ovarian follicle development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
myeloid progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
lymphoid progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
immature B cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell chemotaxis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of dendritic cell cytokine production	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
glycosphingolipid metabolic process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
inflammatory response	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
spermatogenesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
spermatid development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
germ cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of cell shape	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
visual learning	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
male gonad development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of phospholipase C activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytokine-mediated signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell population maintenance	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
lamellipodium assembly	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
actin cytoskeleton organization	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hemopoiesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
T cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
erythrocyte differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of pseudopodium assembly	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of mast cell cytokine production	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
somatic stem cell population maintenance	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
embryonic hemopoiesis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
ectopic germ cell programmed cell death	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
intracellular signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hematopoietic stem cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
megakaryocyte development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
Fc receptor signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
Kit signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
erythropoietin-mediated signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of cell population proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of programmed cell death	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell degranulation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of MAPK cascade	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
pigmentation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
tongue development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of Notch signaling pathway	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
response to cadmium ion	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein autophosphorylation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of long-term neuronal synaptic plasticity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
digestive tract development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
epithelial cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of sound	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of developmental process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cell chemotaxis	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
mast cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of mast cell proliferation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
melanocyte adhesion	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of pyloric antrum smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
regulation of bile acid metabolic process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of colon smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of small intestine smooth muscle contraction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
negative regulation of reproductive process	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of cell migration	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
positive regulation of MAP kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
multicellular organism development	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
B cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cellular response to reactive oxygen species	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
luteinization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
in utero embryonic development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell activation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
estrogen metabolic process	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell population proliferation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
negative regulation of platelet activation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of phospholipase C activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
signal transduction involved in regulation of gene expression	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
extracellular matrix organization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
lung development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
adrenal gland development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell migration	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
male genitalia development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
regulation of actin cytoskeleton organization	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
Leydig cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor-alpha signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
wound healing	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein autophosphorylation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of fibroblast proliferation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic digestive tract morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
embryonic skeletal system morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
white fat cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of chemotaxis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cardiac myofibril assembly	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
roof of mouth development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
face morphogenesis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell chemotaxis	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
retina vasculature development in camera-type eye	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet aggregation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cellular response to amino acid stimulus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
metanephric glomerular capillary formation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
regulation of mesenchymal stem cell differentiation	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
multicellular organism development	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Fibroblast growth factor receptor 2	Homo sapiens (human)
angiogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
ureteric bud development	Fibroblast growth factor receptor 2	Homo sapiens (human)
in utero embryonic development	Fibroblast growth factor receptor 2	Homo sapiens (human)
epithelial to mesenchymal transition	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
outflow tract septum morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
membranous septum morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
endochondral bone growth	Fibroblast growth factor receptor 2	Homo sapiens (human)
apoptotic process	Fibroblast growth factor receptor 2	Homo sapiens (human)
cell-cell signaling	Fibroblast growth factor receptor 2	Homo sapiens (human)
axonogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of smoothened signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
post-embryonic development	Fibroblast growth factor receptor 2	Homo sapiens (human)
embryonic pattern specification	Fibroblast growth factor receptor 2	Homo sapiens (human)
animal organ morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of phospholipase activity	Fibroblast growth factor receptor 2	Homo sapiens (human)
negative regulation of keratinocyte proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
morphogenesis of embryonic epithelium	Fibroblast growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Fibroblast growth factor receptor 2	Homo sapiens (human)
orbitofrontal cortex development	Fibroblast growth factor receptor 2	Homo sapiens (human)
ventricular zone neuroblast division	Fibroblast growth factor receptor 2	Homo sapiens (human)
pyramidal neuron development	Fibroblast growth factor receptor 2	Homo sapiens (human)
gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of Wnt signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
bone mineralization	Fibroblast growth factor receptor 2	Homo sapiens (human)
lung development	Fibroblast growth factor receptor 2	Homo sapiens (human)
epithelial cell differentiation	Fibroblast growth factor receptor 2	Homo sapiens (human)
midbrain development	Fibroblast growth factor receptor 2	Homo sapiens (human)
otic vesicle formation	Fibroblast growth factor receptor 2	Homo sapiens (human)
hair follicle morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
response to lipopolysaccharide	Fibroblast growth factor receptor 2	Homo sapiens (human)
lacrimal gland development	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of osteoblast proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
organ growth	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in hemopoiesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	Fibroblast growth factor receptor 2	Homo sapiens (human)
inner ear morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
odontogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of MAPK cascade	Fibroblast growth factor receptor 2	Homo sapiens (human)
cell fate commitment	Fibroblast growth factor receptor 2	Homo sapiens (human)
response to ethanol	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of osteoblast differentiation	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of cell cycle	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Fibroblast growth factor receptor 2	Homo sapiens (human)
protein autophosphorylation	Fibroblast growth factor receptor 2	Homo sapiens (human)
lung alveolus development	Fibroblast growth factor receptor 2	Homo sapiens (human)
mesodermal cell differentiation	Fibroblast growth factor receptor 2	Homo sapiens (human)
embryonic digestive tract morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
embryonic organ morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
digestive tract development	Fibroblast growth factor receptor 2	Homo sapiens (human)
embryonic organ development	Fibroblast growth factor receptor 2	Homo sapiens (human)
reproductive structure development	Fibroblast growth factor receptor 2	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
skeletal system morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
epidermis morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
branching morphogenesis of a nerve	Fibroblast growth factor receptor 2	Homo sapiens (human)
mesenchymal cell differentiation	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of smooth muscle cell differentiation	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of cell division	Fibroblast growth factor receptor 2	Homo sapiens (human)
ventricular cardiac muscle tissue morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
limb bud formation	Fibroblast growth factor receptor 2	Homo sapiens (human)
bone development	Fibroblast growth factor receptor 2	Homo sapiens (human)
bone morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
branching involved in prostate gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
branching involved in salivary gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
bud elongation involved in lung branching	Fibroblast growth factor receptor 2	Homo sapiens (human)
lung lobe morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
lung-associated mesenchyme development	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of epithelial cell proliferation involved in lung morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
prostate gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
prostate epithelial cord elongation	Fibroblast growth factor receptor 2	Homo sapiens (human)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification	Fibroblast growth factor receptor 2	Homo sapiens (human)
lateral sprouting from an epithelium	Fibroblast growth factor receptor 2	Homo sapiens (human)
mammary gland bud formation	Fibroblast growth factor receptor 2	Homo sapiens (human)
epithelial cell proliferation involved in salivary gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
branch elongation involved in salivary gland morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
branching involved in labyrinthine layer morphogenesis	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of morphogenesis of a branching structure	Fibroblast growth factor receptor 2	Homo sapiens (human)
mesenchymal cell differentiation involved in lung development	Fibroblast growth factor receptor 2	Homo sapiens (human)
mesenchymal cell proliferation involved in lung development	Fibroblast growth factor receptor 2	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Fibroblast growth factor receptor 2	Homo sapiens (human)
cellular response to retinoic acid	Fibroblast growth factor receptor 2	Homo sapiens (human)
cellular response to hypoxia	Fibroblast growth factor receptor 2	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Fibroblast growth factor receptor 2	Homo sapiens (human)
multicellular organism development	Fibroblast growth factor receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Fibroblast growth factor receptor 2	Homo sapiens (human)
positive regulation of macrophage chemotaxis	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of macrophage proliferation	Mitogen-activated protein kinase 3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
DNA-templated transcription	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
apoptotic process	Mitogen-activated protein kinase 3	Homo sapiens (human)
insulin receptor signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
Schwann cell development	Mitogen-activated protein kinase 3	Homo sapiens (human)
phosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
sensory perception of pain	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of ossification	Mitogen-activated protein kinase 3	Homo sapiens (human)
BMP signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of cellular pH	Mitogen-activated protein kinase 3	Homo sapiens (human)
thyroid gland development	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of cyclase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of stress-activated MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 3	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
outer ear morphogenesis	Mitogen-activated protein kinase 3	Homo sapiens (human)
myelination	Mitogen-activated protein kinase 3	Homo sapiens (human)
signal transduction in response to DNA damage	Mitogen-activated protein kinase 3	Homo sapiens (human)
response to exogenous dsRNA	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 3	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
thymus development	Mitogen-activated protein kinase 3	Homo sapiens (human)
modulation of chemical synaptic transmission	Mitogen-activated protein kinase 3	Homo sapiens (human)
cartilage development	Mitogen-activated protein kinase 3	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of cytoskeleton organization	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomerase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
Bergmann glial cell differentiation	Mitogen-activated protein kinase 3	Homo sapiens (human)
face development	Mitogen-activated protein kinase 3	Homo sapiens (human)
lung morphogenesis	Mitogen-activated protein kinase 3	Homo sapiens (human)
trachea formation	Mitogen-activated protein kinase 3	Homo sapiens (human)
cardiac neural crest cell development involved in heart development	Mitogen-activated protein kinase 3	Homo sapiens (human)
ERK1 and ERK2 cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
response to epidermal growth factor	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to tumor necrosis factor	Mitogen-activated protein kinase 3	Homo sapiens (human)
caveolin-mediated endocytosis	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of Golgi inheritance	Mitogen-activated protein kinase 3	Homo sapiens (human)
xenophagy	Mitogen-activated protein kinase 3	Homo sapiens (human)
negative regulation of TORC1 signaling	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomere capping	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of xenophagy	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of early endosome to late endosome transport	Mitogen-activated protein kinase 3	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 3	Homo sapiens (human)
branching involved in blood vessel morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of macroautophagy	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial depolarization	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mitochondrial fission	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ovarian follicle development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of protein phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lymph vessel development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell maturation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endocardium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelium development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell population proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of cell shape	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
mesenchymal cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of gene expression	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of BMP signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
embryonic hemopoiesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor-2 signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
surfactant homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of neuron apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell fate commitment	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein autophosphorylation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
lung alveolus development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
post-embryonic camera-type eye morphogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
epithelial cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of positive chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of focal adhesion assembly	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
calcium ion homeostasis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
blood vessel endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular wound healing	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
semaphorin-plexin signaling pathway	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of hematopoietic progenitor cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of bone development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cellular response to hydrogen sulfide	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of stem cell proliferation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of vasculogenesis	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
regulation of MAPK cascade	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
multicellular organism development	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell migration	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endothelial cell differentiation	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (56)

Process	via Protein(s)	Taxonomy
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
virus receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
chromatin binding	Epidermal growth factor receptor	Homo sapiens (human)
double-stranded DNA binding	Epidermal growth factor receptor	Homo sapiens (human)
MAP kinase kinase kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane signaling receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
integrin binding	Epidermal growth factor receptor	Homo sapiens (human)
protein binding	Epidermal growth factor receptor	Homo sapiens (human)
calmodulin binding	Epidermal growth factor receptor	Homo sapiens (human)
ATP binding	Epidermal growth factor receptor	Homo sapiens (human)
enzyme binding	Epidermal growth factor receptor	Homo sapiens (human)
kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
ubiquitin protein ligase binding	Epidermal growth factor receptor	Homo sapiens (human)
identical protein binding	Epidermal growth factor receptor	Homo sapiens (human)
cadherin binding	Epidermal growth factor receptor	Homo sapiens (human)
actin filament binding	Epidermal growth factor receptor	Homo sapiens (human)
ATPase binding	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor binding	Epidermal growth factor receptor	Homo sapiens (human)
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
protein tyrosine kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
ATP binding	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Hepatocyte growth factor receptor	Homo sapiens (human)
identical protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
molecular function activator activity	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protease binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein tyrosine kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
stem cell factor receptor activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
ATP binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytokine binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
SH2 domain binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein homodimerization activity	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
metal ion binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
growth factor binding	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
protein kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor alpha-receptor activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor receptor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
ATP binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
vascular endothelial growth factor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein homodimerization activity	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein-containing complex binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
platelet-derived growth factor binding	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein tyrosine kinase activity	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor receptor activity	Fibroblast growth factor receptor 2	Homo sapiens (human)
protein binding	Fibroblast growth factor receptor 2	Homo sapiens (human)
ATP binding	Fibroblast growth factor receptor 2	Homo sapiens (human)
heparin binding	Fibroblast growth factor receptor 2	Homo sapiens (human)
fibroblast growth factor binding	Fibroblast growth factor receptor 2	Homo sapiens (human)
protein homodimerization activity	Fibroblast growth factor receptor 2	Homo sapiens (human)
phosphotyrosine residue binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
phosphatase binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
identical protein binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
DNA-binding transcription factor binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
integrin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
ATP binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
coreceptor activity	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
vascular endothelial growth factor binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
identical protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cadherin binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Hsp90 protein binding	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (54)

Process	via Protein(s)	Taxonomy
endosome	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
ruffle membrane	Epidermal growth factor receptor	Homo sapiens (human)
Golgi membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular space	Epidermal growth factor receptor	Homo sapiens (human)
nucleus	Epidermal growth factor receptor	Homo sapiens (human)
cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
endosome	Epidermal growth factor receptor	Homo sapiens (human)
endoplasmic reticulum membrane	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
focal adhesion	Epidermal growth factor receptor	Homo sapiens (human)
cell surface	Epidermal growth factor receptor	Homo sapiens (human)
endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane	Epidermal growth factor receptor	Homo sapiens (human)
basolateral plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
apical plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
cell junction	Epidermal growth factor receptor	Homo sapiens (human)
clathrin-coated endocytic vesicle membrane	Epidermal growth factor receptor	Homo sapiens (human)
early endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
nuclear membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane raft	Epidermal growth factor receptor	Homo sapiens (human)
perinuclear region of cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
multivesicular body, internal vesicle lumen	Epidermal growth factor receptor	Homo sapiens (human)
intracellular vesicle	Epidermal growth factor receptor	Homo sapiens (human)
protein-containing complex	Epidermal growth factor receptor	Homo sapiens (human)
receptor complex	Epidermal growth factor receptor	Homo sapiens (human)
Shc-EGFR complex	Epidermal growth factor receptor	Homo sapiens (human)
basal plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
extracellular region	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface	Hepatocyte growth factor receptor	Homo sapiens (human)
membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
postsynapse	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
receptor complex	Hepatocyte growth factor receptor	Homo sapiens (human)
fibrillar center	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
acrosomal vesicle	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
extracellular space	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cell-cell junction	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
external side of plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
cytoplasmic side of plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
plasma membrane	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
receptor complex	Mast/stem cell growth factor receptor Kit	Homo sapiens (human)
nucleus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
nucleoplasm	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cytoplasm	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
endoplasmic reticulum membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
Golgi apparatus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
microvillus	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cilium	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
external side of plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
cell junction	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
protein-containing complex	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
receptor complex	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor alpha	Homo sapiens (human)
collagen-containing extracellular matrix	Fibroblast growth factor receptor 2	Homo sapiens (human)
extracellular region	Fibroblast growth factor receptor 2	Homo sapiens (human)
nucleus	Fibroblast growth factor receptor 2	Homo sapiens (human)
cytoplasm	Fibroblast growth factor receptor 2	Homo sapiens (human)
Golgi apparatus	Fibroblast growth factor receptor 2	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 2	Homo sapiens (human)
cell cortex	Fibroblast growth factor receptor 2	Homo sapiens (human)
cell surface	Fibroblast growth factor receptor 2	Homo sapiens (human)
membrane	Fibroblast growth factor receptor 2	Homo sapiens (human)
cytoplasmic vesicle	Fibroblast growth factor receptor 2	Homo sapiens (human)
excitatory synapse	Fibroblast growth factor receptor 2	Homo sapiens (human)
receptor complex	Fibroblast growth factor receptor 2	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 2	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 3	Homo sapiens (human)
nuclear envelope	Mitogen-activated protein kinase 3	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 3	Homo sapiens (human)
early endosome	Mitogen-activated protein kinase 3	Homo sapiens (human)
late endosome	Mitogen-activated protein kinase 3	Homo sapiens (human)
endoplasmic reticulum lumen	Mitogen-activated protein kinase 3	Homo sapiens (human)
Golgi apparatus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoskeleton	Mitogen-activated protein kinase 3	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase 3	Homo sapiens (human)
caveola	Mitogen-activated protein kinase 3	Homo sapiens (human)
focal adhesion	Mitogen-activated protein kinase 3	Homo sapiens (human)
pseudopodium	Mitogen-activated protein kinase 3	Homo sapiens (human)
glutamatergic synapse	Mitogen-activated protein kinase 3	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
extracellular region	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
nucleus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
early endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
endoplasmic reticulum	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
Golgi apparatus	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
external side of plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
cell junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
membrane raft	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
anchoring junction	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
sorting endosome	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
plasma membrane	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
receptor complex	Vascular endothelial growth factor receptor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (54)

Assay ID	Title	Year	Journal	Article
AID241262	Inhibition of epidermal growth factor receptor in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241663	Inhibition of vascular endothelial growth factor receptor 2 in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID245810	Tumor growth inhibition ratio against DLD-1 tumor cells after oral administration at 20 mg/kg/day	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID1129404	Growth inhibition of HUVEC by WST-8 assay	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
AID646188	Antiangiogenic activity in HUVEC assessed as inhibition of cell proliferation after 72 hrs by MTT assay	2012	Journal of natural products, Jan-27, Volume: 75, Issue:1	Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.
AID241407	Inhibition of fibroblast growth factor receptor 2 in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241626	Inhibition of proto-oncogene tyrosine-protein kinase kit in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241322	Inhibition of epidermal growth factor receptor in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241725	Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241358	Inhibition of hepatocyte growth factor receptor in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID240750	Inhibition of protein kinase A in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID646189	Antiangiogenic activity in HUAEC assessed as inhibition of cell proliferation after 72 hrs by MTT assay	2012	Journal of natural products, Jan-27, Volume: 75, Issue:1	Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.
AID241264	Inhibition of mitogen activated protein kinase in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID240922	Inhibition of protein kinase C alpha in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID240802	Inhibition of Insulin receptor in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID1129405	Inhibition of recombinant human VEGFR2	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
AID245809	Tumor growth inhibition ratio against St-4 tumor cells after oral administration at 20 mg/kg/day	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241726	Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID241528	Inhibition of mitogen activated protein kinase kinase 1 in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID245806	Tumor growth inhibition ratio against A375 tumor cells after oral administration at 20 mg/kg/day	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID245808	Tumor growth inhibition ratio against LC-6 tumor cells after oral administration at 20 mg/kg/day	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID245807	Tumor growth inhibition ratio against GL07 tumor cells after oral administration at 20 mg/kg/day	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID240885	Inhibition of c-Src tyrosine kinase in cell-free assay	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347412	qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (5.26)	29.6817
2010's	11 (57.89)	24.3611
2020's	7 (36.84)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.07	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
arginyl-glycyl-aspartyl-serine arginyl-glycyl-aspartyl-serine: corresponds to cell attachment site of fibronectin; located near carboxyl-terminal region of alpha-chain of fibrinogen; inhibits platelet aggregation & fibrinogen binding to activated platelets	2.15	1
u 0126 U 0126: protein kinase kinase inhibitor; structure in first source	2.13	1	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent
su 1498 SU 1498: structure in first source. SU1498 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine.	2.08	1	enamide; monocarboxylic acid amide; nitrile; phenols; secondary carboxamide	vascular endothelial growth factor receptor antagonist
3-(4-dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one 3-(4-dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one: structure in first source	2.13	1
g(m3) ganglioside G(M3) Ganglioside: A ganglioside present in abnormally large amounts in the brain and liver due to a deficient biosynthetic enzyme, G(M3):UDP-N-acetylgalactosaminyltransferase. Deficiency of this enzyme prevents the formation of G(M2) ganglioside from G(M3) ganglioside and is the cause of an anabolic sphingolipidosis.. alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/24:1(15Z)) : A sialotriaosylceramide consisting of beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide(d18:1/24:1(15Z)).	2.21	1	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide; sialodiosylceramide; sialotriaosylceramide	mouse metabolite

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Breast Cancer [description not available]	2.61	2
Angiogenesis, Pathologic [description not available]	2.84	3
Breast Neoplasms Tumors or cancer of the human BREAST.	2.61	2
Grippe [description not available]	2.21	1
Infections, Orthomyxoviridae [description not available]	2.21	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	2.21	1
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	2.21	1
Astrocytoma, Grade IV [description not available]	2.08	1
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	2.08	1
Peripheral Nerve Injury [description not available]	2.08	1
Peripheral Nerve Injuries Injuries to the PERIPHERAL NERVES.	2.08	1
Benign Neoplasms [description not available]	2.07	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.07	1

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