| Assay ID | Title | Year | Journal | Article |
|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1149733 | Inhibition of respiration in mouse Ehrlich ascites cells after 30 mins incubation at 37 degC by whole cell model | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration. |
| AID1494470 | Inhibition of Rickettsia prowazekii N-terminal His6-tagged methionine aminopeptidase 1 expressed in Escherichia coli DLB3 Rosetta cells at 10 uM using Met-AMC as substrate preincubated for 1 hr followed by 30 mins incubation after substrate addition measu | 2018 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8
| The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications. |
| AID1557097 | Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Structural development of a type-1 ryanodine receptor (RyR1) Ca |
| AID481987 | Antioxidant activity assessed as residual DPPH radical scavenging activity at 1.5 mM after 30 mins relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID1149735 | Lipophilicity, log P of the compound | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration. |
| AID1880738 | Binding affinity to DC-SIGN ECD (66 to 404 residue) (unknown origin) expressed in Escherichia coli BL21 assessed as dissociation constant by STD reporter assay based NMR spectroscopy analysis | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold. |
| AID481986 | Antioxidant activity assessed as residual galvinoxyl radical scavenging activity at 1.5 mM after 30 mins relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID481991 | Antioxidant activity against AAPH-induced DNA damage assessed as TBARS production at 200 uM after 4 hrs relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID481990 | Antioxidant activity against hydroxyl radical-induced DNA damage assessed as TBARS production at 400 uM after 30 mins relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID1557098 | Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER up to 30 uM prestimulated with doxycycline for 24 to 28 hrs followed by compound addition | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Structural development of a type-1 ryanodine receptor (RyR1) Ca |
| AID481988 | Antioxidant activity against AAPH-induced linoleic acid oxidation assessed as exhausted methyl linoleate at 2 mM after 4 hrs relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID481985 | Antioxidant activity assessed as residual ABTS cationic radical scavenging activity at 1.5 mM after 30 mins relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID481992 | Antioxidant activity against Cu(2+)/GSH-induced DNA damage assessed as TBARS production at 200 uM after 4 hrs relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID66147 | Inhibition of Ehrlich ascites cell respiration | 1982 | Journal of medicinal chemistry, Jan, Volume: 25, Issue:1
| 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. |
| AID99373 | Ability to inhibit skeletal muscle LDH (LDH-M4); Inactive | 1982 | Journal of medicinal chemistry, Jan, Volume: 25, Issue:1
| 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. |
| AID55117 | Ability to inhibit cytoplasmic malate dehydrogenase; Inactive | 1982 | Journal of medicinal chemistry, Jan, Volume: 25, Issue:1
| 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. |
| AID481989 | Antioxidant activity against beta-carotene bleaching assessed as decrease of absorbance at 0.3 mM after 100 mins relative to control | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5
| Dichloro-4-quinolinol-3-carboxylic acid: synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA. |
| AID126591 | Ability to inhibit mitochondrial malate dehydrogenase; Inactive | 1982 | Journal of medicinal chemistry, Jan, Volume: 25, Issue:1
| 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. |
| AID271563 | Residual activity of human CK2 at 30 uM | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |