laherradurin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

laherradurin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	44374350
CHEMBL ID	160640
MeSH ID	M0395467

Synonyms (3)

Synonym
laherradurin
CHEMBL160640
bdbm50403903

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)	IC50 (µMol)	0.0002	0.0002	0.0022	0.0051	AID144497
Acyl carrier protein, mitochondrial	Bos taurus (cattle)	IC50 (µMol)	0.0002	0.0002	0.0022	0.0051	AID144497
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Process	via Protein(s)	Taxonomy
mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
transmembrane transport	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
mitochondrial electron transport, NADH to ubiquinone	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
fatty acid biosynthetic process	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
mitochondrial respiratory chain complex I assembly	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
[2Fe-2S] cluster assembly	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
transmembrane transport	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Process	via Protein(s)	Taxonomy
NADH dehydrogenase (ubiquinone) activity	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
FMN binding	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
metal ion binding	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
NAD binding	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
4 iron, 4 sulfur cluster binding	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
fatty acid binding	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
NADH dehydrogenase (ubiquinone) activity	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
oxidoreductase activity	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
mitochondrial large ribosomal subunit binding	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Process	via Protein(s)	Taxonomy
mitochondrial inner membrane	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
respiratory chain complex I	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Bos taurus (cattle)
mitochondrial matrix	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
mitochondrial membrane	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
respiratory chain complex I	Acyl carrier protein, mitochondrial	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID234414	Potency relative to NADH oxidase activity of and 36-dihydroisorolliniastatin-1	2001	Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5	Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
AID215474	Relative inhibition of NADH-ubiquinone oxidoreductase (DB) and NADH oxidase activity	2001	Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5	Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
AID144497	Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heart	2001	Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5	Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
AID215473	Inhibition of NADH-ubiquinone oxidoreductase using decylubiquinone (DB) acceptor	2001	Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5	Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
AID427711	Inhibition of NADH oxidase in beef heart submitochondrial particles by end-window spectrophotometry	2009	Journal of natural products, Jul, Volume: 72, Issue:7	Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus (#).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.50 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.30 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	2.04	1
uridine [no description available]	2.05	1	uridines	drug metabolite; fundamental metabolite; human metabolite
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	2.05	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	2.04	1
4-hydroxy-25-desoxyneorollinicin 4-hydroxy-25-desoxyneorollinicin: isol from Rollina papilionella; structure given in first source	2.46	2
acetogenins Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.	2.5	2
rhodamine 123 Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene.	2.04	1	organic cation; xanthene dye	fluorochrome
isomurisolenin isomurisolenin: an acetogenin from seeds of Annona reticulata;	2	1

Condition	Indicated	Relationship Strength	Studies	Trials
Benign Neoplasms [description not available]	0	2.04	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	0	2.04	1	0

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