laherradurin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 44374350 |
| CHEMBL ID | 160640 |
| MeSH ID | M0395467 |
| Synonym |
|---|
| laherradurin |
| CHEMBL160640 |
| bdbm50403903 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) | IC50 (µMol) | 0.0002 | 0.0002 | 0.0022 | 0.0051 | AID144497 |
| Acyl carrier protein, mitochondrial | Bos taurus (cattle) | IC50 (µMol) | 0.0002 | 0.0002 | 0.0022 | 0.0051 | AID144497 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| mitochondrial electron transport, NADH to ubiquinone | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| transmembrane transport | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| mitochondrial electron transport, NADH to ubiquinone | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| fatty acid biosynthetic process | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| mitochondrial respiratory chain complex I assembly | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| [2Fe-2S] cluster assembly | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| transmembrane transport | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| FMN binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| metal ion binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| NAD binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| 4 iron, 4 sulfur cluster binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| fatty acid binding | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| NADH dehydrogenase (ubiquinone) activity | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| oxidoreductase activity | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| mitochondrial large ribosomal subunit binding | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| mitochondrial inner membrane | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| respiratory chain complex I | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
| mitochondrial matrix | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| mitochondrial membrane | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| respiratory chain complex I | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID234414 | Potency relative to NADH oxidase activity of and 36-dihydroisorolliniastatin-1 | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5 | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
| AID215474 | Relative inhibition of NADH-ubiquinone oxidoreductase (DB) and NADH oxidase activity | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5 | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
| AID144497 | Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heart | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5 | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
| AID215473 | Inhibition of NADH-ubiquinone oxidoreductase using decylubiquinone (DB) acceptor | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5 | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
| AID427711 | Inhibition of NADH oxidase in beef heart submitochondrial particles by end-window spectrophotometry | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus (#). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||