Page last updated: 2024-11-13
laherradurin
Description
laherradurin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
Synonyms (3)
Synonym |
laherradurin |
CHEMBL160640 |
bdbm50403903 |
Protein Targets (2)
Inhibition Measurements
Biological Processes (5)
Molecular Functions (8)
Process | via Protein(s) | Taxonomy |
NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
FMN binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
metal ion binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
NAD binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
4 iron, 4 sulfur cluster binding | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) |
fatty acid binding | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
NADH dehydrogenase (ubiquinone) activity | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
oxidoreductase activity | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
mitochondrial large ribosomal subunit binding | Acyl carrier protein, mitochondrial | Bos taurus (cattle) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Ceullar Components (4)
Bioassays (5)
Assay ID | Title | Year | Journal | Article |
AID234414 | Potency relative to NADH oxidase activity of and 36-dihydroisorolliniastatin-1 | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5
| Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
AID215474 | Relative inhibition of NADH-ubiquinone oxidoreductase (DB) and NADH oxidase activity | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5
| Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
AID144497 | Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heart | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5
| Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
AID215473 | Inhibition of NADH-ubiquinone oxidoreductase using decylubiquinone (DB) acceptor | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5
| Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
AID427711 | Inhibition of NADH oxidase in beef heart submitochondrial particles by end-window spectrophotometry | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Terretonins E and F, inhibitors of the mitochondrial respiratory chain from the marine-derived fungus Aspergillus insuetus (#). |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (80.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.50 (24.57) | Research Supply Index | 1.79 (2.92) | Research Growth Index | 4.30 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |