| Assay ID | Title | Year | Journal | Article |
|---|
| AID9515 | Half life was evaluated in dog | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID210997 | Binding affinity towards human thrombin | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Benzylamine-based selective and orally bioavailable inhibitors of thrombin. |
| AID7811 | Apparent permeability coefficient (Papp) was determined in human Caco-2 cell monolayer (n = 3) | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Benzylamine-based selective and orally bioavailable inhibitors of thrombin. |
| AID215016 | Compound was tested for inhibitory activity against bovine trypsin | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID211195 | In vitro inhibition of human thrombin. | 2000 | Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24
| Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1. |
| AID211017 | Compound was evaluated for its inhibitory activity against human thrombin | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Potent and efficacious thienylamidine-incorporated thrombin inhibitors. |
| AID12133 | Absorption behavior was judged by the area under the curve, determined after oral dose of 30 mg/kg in rats. | 1999 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
| Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption. |
| AID211211 | Inhibitory constant against human thrombin was determined in vitro. | 1999 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
| Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption. |
| AID11396 | Absorption behavior was judged by the peak blood concentration determined after oral dose of 30 mg/kg in rats. | 1999 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
| Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption. |
| AID215186 | Compound was evaluated for its inhibitory activity against bovine trypsin | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Potent and efficacious thienylamidine-incorporated thrombin inhibitors. |
| AID89356 | Concentration of inhibitor in human plasma required to double the activated partial thromboplastin time (aPTT) | 2000 | Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24
| Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1. |
| AID211037 | Compound was tested for inhibitory activity against human thrombin | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID211022 | Binding affinity against human thrombin | 2002 | Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7
| Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1. |
| AID228031 | The compound was tested for inhibitory activity against tissue plasminogen activator | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID213271 | Compound was tested for inhibitory activity against bovine thrombin | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID8500 | Compound was tested for percent of oral bioavailability at 10 mg/ml dose in dogs | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID51684 | The compound was tested for inhibitory activity against Coagulation factor X | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID215206 | Inhibitory constant against bovine trypsin was determined in vitro. | 1999 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
| Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption. |
| AID158142 | The compound was tested for inhibitory activity against human plasmin | 1998 | Bioorganic & medicinal chemistry letters, Mar-17, Volume: 8, Issue:6
| Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
| AID215201 | Inhibitory activity against Bovine Trypsin | 2000 | Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24
| Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |