| Assay ID | Title | Year | Journal | Article |
|---|
| AID1191394 | Inhibition of sheep brain tubulin polymerization by DAPI staining-based fluorescence assay | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. |
| AID1529523 | Inhibition of human recombinant HDAC11 at 10'-5 M after 45 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1529519 | Inhibition of human recombinant HDAC7 at 10'-5 M after 45 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1458854 | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining after 120 mins in presence of NADPH by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1862615 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1191396 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTitre-Blue assay | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. |
| AID1832034 | Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID397295 | Cell cycle arrest in human K562 cells assessed as decrease in S phase accumulation after 24 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1862610 | Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1862631 | Metabolic stability in rat liver microsomes assessed as intrinsic clearance per mg protein measured upto 6 hrs in presence of NADPH generating system by HPLC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID397296 | Cell cycle arrest in human K562 cells assessed as decrease in G1 phase accumulation after 24 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID397290 | Cytotoxicity against human K562 cells after 72 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1463415 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions. |
| AID1529535 | Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1862622 | Inhibition of HDAC11 (unknown origin) measured by fluorometry assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1458825 | Antiproliferative activity against human A549/CDDP cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1534541 | Drug metabolism in rat liver microsomes assessed as cytochrome P450-mediated 6-(1-(3-hydroxy-4-methoxyphenyl)vinyl)-2,3,4-trimethoxyphenol metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1126658 | Antiangiogenic activity in human ECFC co-cultured with human ADSC assessed as inhibition of VEGF-induced endothelial colony tube formation after 96 hrs | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Discovery of azaisoerianin derivatives as potential antitumors agents. |
| AID1737778 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at S phase at 12 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 53.42%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1737735 | against C against y against t against o against t against o against x against i against c against i against t against y against against against a against g against a against i against n against s against t against against against h against u against m aga | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1534537 | Aqueous solubility of the compound in phosphate buffer at pH 7.4 after 4 hrs by HPLC-UV analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1727334 | Cytotoxicity against PHA-activated human peripheral blood lymphocytes assessed as cell viability after 72 hrs by luminescent assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1529554 | Aqueous solubility of the compound | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1348620 | Antiproliferative activity against human U87 cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1862630 | Metabolic stability in rat liver microsomes assessed as half-life measured upto 6 hrs in presence of NADPH generating system by HPLC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1534524 | Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1458827 | Resistance index, ratio of IC50 for human A549/CDDP cells to IC50 for human A549 cells | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1862612 | Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1529514 | Inhibition of human recombinant HDAC2 at 10'-5 M after 15 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1727315 | Antiproliferative activity against human A549 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1534525 | Antiproliferative activity against human K562 cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1529532 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1737779 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 12 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 7.83%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1458824 | Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1592976 | Cytotoxicity against human K562R cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1862609 | Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1862608 | Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1727311 | Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID397291 | Cytotoxicity against human H1299 cells after 72 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1529530 | Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID397294 | Cell cycle arrest in human K562 cells assessed as increase in G2/M phase accumulation after 24 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1862611 | Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1862633 | Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg protein measured upto 6 hrs in presence of NADPH generating system by HPLC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1534526 | Antiproliferative activity against human K562R cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID735016 | Inhibition of sheep brain tubulin polymerization assessed as decrease in rate of microtubule assembly by fluorimeter analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs. |
| AID735019 | Growth inhibition of human K562 cells after 72 hrs by Victor microtiter plate fluorimeter analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs. |
| AID1458822 | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1458823 | Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1438689 | Cytotoxicity against human HCT116 cells assessed as decrease in cell growth after 72 hrs by resazurin dye-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1438686 | Cytotoxicity against human K562 cells assessed as decrease in cell growth after 72 hrs by resazurin dye-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1529533 | Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1458855 | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining after 150 mins in presence of NADPH by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1529548 | Induction of apoptosis in human BL2 cells assessed as early apoptotic cells at 10 nM after 48 hrs by annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 8.2%) | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1529522 | Inhibition of human recombinant HDAC10 at 10'-5 M after 45 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1458816 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1529550 | Cytotoxicity against human PBL cells assessed as cell growth inhibition after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID658262 | Cytotoxicity against human K562 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity. |
| AID1458853 | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining after 90 mins in presence of NADPH by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1534534 | Half life in human liver microsomes at 100 uM in presence of NADPH generating system and glucose-6-phosphate by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1862616 | Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID397289 | Cytotoxicity against human HCT116 cells after 72 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1463418 | Inhibition of porcine brain tubulin polymerization at 3 uM incubated for 80 mins by fluorescence based spectrophotometry | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions. |
| AID1529526 | Inhibition of human recombinant HDAC11 after 30 mins using fluorogenic substrate by fluorimetric assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID735017 | Growth inhibition of human H1299 cells after 72 hrs by Victor microtiter plate fluorimeter analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs. |
| AID1832023 | Drug metabolism in rat liver microsomes assessed as hydroxylated metabolite formation measured after 96 hrs by ESI-HRMS assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1529510 | Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1529516 | Inhibition of human recombinant HDAC4 at 10'-5 M after 30 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1529529 | Antiproliferative activity against human K562R cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1737732 | Antiproliferative against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1529528 | Antiproliferative activity against human K562 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID510857 | Inhibition of sheep brain tubulin microtubule assembly by turbidimetry assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4. |
| AID1529525 | Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1832026 | Drug metabolism in human liver microsomes assessed as hydroxylated metabolite formation measured after 96 hrs by ESI-HRMS assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1438683 | Cytotoxicity against human U87 cells assessed as decrease in cell growth after 72 hrs by resazurin dye-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1534552 | Drug metabolism in human liver microsomes assessed as cytochrome P450-mediated O-demethylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1529511 | Inhibition of sheep brain tubulin polymerization assessed as reduction in rate of microtubule assembly by DAPI-fluorescence based assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1737738 | Displacement of [3H]colchicine from porcine brain tubulin at 5 uM incubated for 2 hrs by TopCount scintillation counting method relative to control | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1529513 | Inhibition of human recombinant HDAC1 at 10'-5 M after 15 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1458819 | Antiproliferative activity against human RKO cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1295244 | Inhibition of sheep brain tubulin polymerization preincubated for 1 hr measured after 30 mins by turbidimetric-spectrophotometric method | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents. |
| AID1737736 | Inhibition of porcine brain tubulin polymerization assessed as inhibition of microtubule assembly by measuring decrease in absorbance measured for 60 mins by fluorescence based analysis | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1534522 | Inhibition of sheep brain tubulin polymerization by DAPI-fluorescence based fluorimetry | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1458859 | Induction of microtubule disruption in human A549 cells at 5 to 10 nM after 8 to 24 hrs by Hoechst 33342 staining-based laser scanning confocal immunofluorescence microscopic analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1458858 | Inhibition of porcine brain tubulin polymerization measured every 60 seconds for 90 mins by DAPI staining-based fluorescence assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1737777 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G1 phase at 12 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 38.75%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1458820 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1592970 | Cytotoxicity against human A2780 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1438688 | Cytotoxicity against human A549 cells assessed as decrease in cell growth after 72 hrs by resazurin dye-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1529549 | Induction of apoptosis in human BL2 cells assessed as late apoptotic cells at 10 nM after 48 hrs by annexin V-FITC/propidium iodide double staining-based flow cytometry (Rvb = 2.1%) | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1529521 | Inhibition of human recombinant HDAC9 at 10'-5 M after 30 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1862620 | Inhibition of HDAC6 (unknown origin) measured by fluorometry assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1348621 | Antiproliferative activity against human MCF7 cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1348622 | Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1737733 | against A against n against t against i against p against r against o against l against i against f against e against r against a against t against i against v against e against against a against c against t against i against v against i against t against | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID735015 | Growth inhibition of hormone-independent human MDA-MB-231 cells after 72 hrs by Victor microtiter plate fluorimeter analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs. |
| AID1737775 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at S phase at 6 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 53.42%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1458852 | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining after 60 mins in presence of NADPH by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1458815 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1737788 | Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth by MTT assay | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1862614 | Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID658263 | Inhibition of sheep brain tubulin polymerization using DAPI by fluorescence assay | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity. |
| AID1534553 | Drug metabolism in rat liver microsomes assessed as cytochrome P450-mediated O-demethylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1592973 | Cytotoxicity against human A2780R cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1534540 | Drug metabolism in human liver microsomes assessed as cytochrome P450-mediated 6-(1-(3-hydroxy-4-methoxyphenyl)vinyl)-2,3,4-trimethoxyphenol metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1862613 | Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1862628 | Inhibition of tubulin polymerization in human HeLa cells assessed as microtubule network polymerization after 30 mins by immunofluorescence analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID658261 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity. |
| AID1832035 | Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1534547 | Drug metabolism in rat liver microsomes assessed as cytochrome P450-mediated N-demethylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1529531 | Antiproliferative activity against human U87 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1458851 | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining after 30 mins in presence of NADPH by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1438687 | Cytotoxicity against human K562R cells assessed as decrease in cell growth after 72 hrs by resazurin dye-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1534536 | Lipophilicity, log P of the compound after 24 hrs by HPLC analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1727317 | Antiproliferative activity against human HT-29 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1191395 | Cytotoxicity against human H1299 cells after 72 hrs by CellTitre-Blue assay | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. |
| AID1534549 | Drug metabolism in rat liver microsomes assessed as cytochrome P450-mediated hydroxylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1832028 | Metabolic stability in rat liver microsomes assessed as half life measured after 96 hrs by HPLC-MS/MS analysis | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1458828 | Resistance index, ratio of IC50 for human HepG2/DOX cells to IC50 for human HepG2 cells | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1832033 | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1529563 | Antiproliferative activity against human HT-29 cells in presence of TSA after 72 hrs by MTS assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1727333 | Cytotoxicity against human peripheral blood lymphocytes assessed as cell viability after 72 hrs by luminescent assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1458856 | Half life in Sprague-Dawley rat by UV-based HPLC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1458818 | Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1737773 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 3 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 7.83%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1348617 | Antiproliferative activity against human HCT116 cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1529527 | Antiproliferative activity against human A549 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1191397 | Cytotoxicity against human K562 cells after 72 hrs by CellTitre-Blue assay | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. |
| AID1438684 | Inhibition of sheep brain tubulin assembly by DAPI staining-based fluorimetric method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. |
| AID1832032 | Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID397293 | Inhibition of tubulin polymerization assessed as blockade of microtubule assembly | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1529517 | Inhibition of human recombinant HDAC5 at 10'-5 M after 30 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1592971 | Inhibition of sheep brain tubulin polymerization in presence of GTP by DAPI based fluorimetric method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1727314 | Antiproliferative activity against human MiaPaca2 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1727312 | Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1832038 | Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1592977 | Cytotoxicity against human JIMT1 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1592974 | Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1534535 | Half life in rat liver microsomes at 100 uM in presence of NADPH generating system and glucose-6-phosphate by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID732939 | Inhibition of sheep brain tubulin polymerization using DAPI by fluorimetry | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents. |
| AID1737755 | Anti-tumor activity against mouse H22 cells allografted in ICR mice assessed as reduction in tumor weight at 30 mg/kg, iv administered daily for 21 days | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1534548 | Drug metabolism in human liver microsomes assessed as cytochrome P450-mediated hydroxylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID510856 | Cytotoxicity against human HCT116 cells after 72 hrs | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9
| Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4. |
| AID735018 | Growth inhibition of human HCT116 cells after 72 hrs by Victor microtiter plate fluorimeter analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs. |
| AID1458817 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1126642 | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by resazurin dye-based fluorimetric analysis | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Discovery of azaisoerianin derivatives as potential antitumors agents. |
| AID1529520 | Inhibition of human recombinant HDAC8 at 10'-5 M after 60 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1832029 | Metabolic stability in human liver microsomes assessed as half life measured after 96 hrs by HPLC-MS/MS analysis | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1737737 | Displacement of [3H]colchicine from porcine brain tubulin at 1 uM incubated for 2 hrs by TopCount scintillation counting method relative to control | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1737731 | against A against n against t against i against p against r against o against l against i against f against e against r against a against t against i against v against e against against a against c against t against i against v against i against t against | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1832021 | Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID658259 | Cytotoxicity against human HCT116 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity. |
| AID1862629 | Solubility of compound in water | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID397292 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs | 2009 | Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14
| Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. |
| AID1348623 | Inhibition of sheep brain tubulin polymerization assessed as reduction in rate of microtubule assembly by DAPI-fluorescence based assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1534527 | Antiproliferative activity against HUVEC after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1832027 | Drug metabolism in human liver microsomes assessed as O-demethylated metabolite formation measured after 96 hrs by ESI-HRMS assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1529515 | Inhibition of human recombinant HDAC3 at 10'-5 M after 10 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1348619 | Antiproliferative activity against human K562 cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1529524 | Inhibition of human recombinant HDAC6 after 30 mins using fluorogenic substrate by fluorimetric assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1737756 | Anti-tumor activity against mouse H22 cells allografted in ICR mice assessed as reduction in tumor weight at 15 mg/kg, iv administered daily for 21 days | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1832037 | Cytotoxicity against human K-562R cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1529555 | Lipophilicity, log P of the compound | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1727313 | Antiproliferative activity against human K562R cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID658260 | Cytotoxicity against human H1299 cells after 72 hrs using resazurin dye by microtiter plate fluorimeter analysis | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity. |
| AID1832036 | Cytotoxicity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1348618 | Antiproliferative activity against human A549 cells after 72 hrs by resazurin-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. |
| AID1737776 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 6 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 7.83%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1737771 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G1 phase at 3 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 38.75%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1862632 | Metabolic stability in human liver microsomes assessed as half-life measured upto 6 hrs in presence of NADPH generating system by HPLC-MS/MS analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1463416 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions. |
| AID1458826 | Antiproliferative activity against human HepG2/DOX cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| AID1832031 | Cytotoxicity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo reagent based luminescence assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1126643 | Inhibition of sheep brain tubulin assembly by DAPI-staining based fluorescence assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Discovery of azaisoerianin derivatives as potential antitumors agents. |
| AID1529534 | Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1534528 | Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1191392 | Cytotoxicity against human HCT116 cells after 72 hrs by CellTitre-Blue assay | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. |
| AID1534521 | Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1737772 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at S phase at 3 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 53.42%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1592972 | Cytotoxicity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1592975 | Cytotoxicity against human K562 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. |
| AID1862621 | Inhibition of HDAC8 (unknown origin) measured by fluorometry assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1529518 | Inhibition of human recombinant HDAC6 at 10'-5 M after 30 mins using fluorogenic substrate by fluorimetric assay relative to control | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. |
| AID1727316 | Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. |
| AID1832024 | Drug metabolism in rat liver microsomes assessed as O-demethylated metabolite formation measured after 96 hrs by ESI-HRMS assay | 2021 | European journal of medicinal chemistry, Nov-05, Volume: 223 | Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. |
| AID1862606 | Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. |
| AID1737734 | against A against n against t against i against p against r against o against l against i against f against e against r against a against t against i against v against e against against a against c against t against i against v against i against t against | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1737774 | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G1 phase at 6 nM incubated for 48 hrs by propidium iodide/RNase staining based flow cytometry (Rvb = 38.75%) | 2020 | European journal of medicinal chemistry, Jul-01, Volume: 197 | Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. |
| AID1534546 | Drug metabolism in human liver microsomes assessed as cytochrome P450-mediated N-demethylated metabolite formation at 100 uM after 6 hrs in presence of NADPH generating system by HPLC-UV-MS analysis | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1534523 | Antiproliferative activity against human A549 cells after 72 hrs by MTS assay | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. |
| AID1458821 | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |