| Assay ID | Title | Year | Journal | Article |
|---|
| AID301835 | Selectivity for alpha-1B N-type calcium channel over alpha1G T-type calcium channel expressed in HEK293 cells | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID301834 | Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID1058667 | Cytotoxicity against human A2780 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID340030 | Growth inhibition of human HT29 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID1662450 | Inhibition of human Cav3.3 expressed in tsA-201 cells at 10uM by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID1058652 | Ratio of IC50 for mibefradil to compound IC50 for human paclitaxel-resistant A2780T cells | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1058662 | Cell cycle arrest in human A2780 cells assessed as accumulation at S phase at 6 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1058658 | Cell cycle arrest in human A2780 cells assessed as accumulation at sub-G1 phase at 2 to 4 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID340028 | Growth inhibition of human A549 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID1662448 | Inhibition of human Cav3.1 expressed in tsA-201 cells at 10uM by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID527106 | Cytotoxicity against human MDA-MB-231 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID1058661 | Cell cycle arrest in human A2780 cells assessed as accumulation at sub-G1 phase at 8 uM after 24 hrs by FACS analysis (Rvb = 3.1%) | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID340029 | Growth inhibition of human DU145 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID340031 | Growth inhibition of human SK-MEL-2 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID527103 | Cytotoxicity against human LNCAP cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID527104 | Cytotoxicity against human SKOV3 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID527102 | Cytotoxicity against human HeLa cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID340032 | Growth inhibition of human SKOV3 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID301831 | Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current at 10 uM by high throughput screening | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID452446 | Inhibition of human T-type calcium channel alpha1G in HEK293 cells | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| 3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA). |
| AID1058659 | Cell cycle arrest in human paclitaxel-resistant A2780T cells assessed as accumulation at sub-G1 phase at 2 to 4 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID301833 | Selectivity for Alpha-1B N-type calcium channel over alpha-1G T-type calcium channel expressed in HEK293 cells at 10 uM | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID1058670 | Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced current at 1 uM by whole cell patch-clamp method relative to control | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1058657 | Cell cycle arrest in human paclitaxel-resistant A2780T cells assessed as accumulation at sub-G1 phase at 8 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID340033 | Acute toxicity in ICR CD1 mouse assessed as mortality at 1000 mg/kg, po after 5 days | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID1058664 | Cell cycle arrest in human A2780 cells assessed as accumulation at G0/G1 phase at 6 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1662454 | Inhibition of human Cav3.2 expressed in tsA-201 cells by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID1058669 | Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced current by whole cell patch-clamp method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID527107 | Cytotoxicity against human SKBR3 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID527105 | Cytotoxicity against human A172 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID1662453 | Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID301832 | Inhibition of N-type calcium channel Cav3.1 alpha-1B subunit expressed in HEK293 cells assessed as calcium current at 10 uM by patch-clamp assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID340327 | Inhibition of T-type calcium channel Cav3.1 alpha1G expressed in HEK293 cells by whole cell patch-clamp method | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
| AID1058668 | Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID527101 | Cytotoxicity against human A549 cells by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. |
| AID1662449 | Inhibition of human Cav3.2 expressed in tsA-201 cells at 10uM by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID1058663 | Cell cycle arrest in human A2780 cells assessed as accumulation at sub-G1 phase at 6 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1662451 | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID1662452 | Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID1058660 | Cell cycle arrest in human A2780 cells assessed as accumulation at G2/M phase at 6 uM after 24 hrs by FACS analysis | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| AID1662455 | Inhibition of human Cav3.3 expressed in tsA-201 cells by patch clamp electrophysiology | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
| Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
| AID301830 | Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current at 10 uM by patch-clamp assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Discovery of potent T-type calcium channel blocker. |
| AID1058666 | Cytotoxicity against human paclitaxel-resistant A2780T cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
| In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |