Tubulin alpha-8 chain

A tubulin alpha-8 chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY65]

Alpha-tubulin 8;
Tubulin alpha chain-like 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pironetin	Homo sapiens (human)	GI50	0.0222	2	2
pironetin	Homo sapiens (human)	IC50	0.0260	1	1

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
hydrolase activity	molecular function	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
structural constituent of cytoskeleton	molecular function	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]

This protein is located in 2 target(s):

Target	Category	Definition
acrosomal vesicle	cellular component	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. [ISBN:0124325653, ISBN:0198506732]
microtubule cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]

This protein is active in 2 target(s):

Target	Category	Definition
microtubule	cellular component	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 3 target(s):

Target	Category	Definition
spermatid development	biological process	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. [GOC:dph, GOC:go_curators]
mitotic cell cycle	biological process	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
microtubule cytoskeleton organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]