Nucleoside diphosphate kinase, mitochondrial

A nucleoside diphosphate kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00746]

NDK;
NDP kinase, mitochondrial;
EC 2.7.4.6;
Nucleoside diphosphate kinase D;
NDPKD;
nm23-H4

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
balsalazide	Homo sapiens (human)	EC50	45.8000	1	1

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
cardiolipin binding	molecular function	Binding to cardiolipin. [GOC:kmv, GOC:TermGenie]
nucleoside diphosphate kinase activity	molecular function	Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]

This protein is located in 4 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
mitochondrial intermembrane space	cellular component	The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

This protein is involved in 5 target(s):

Target	Category	Definition
GTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732]
UTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. [ISBN:0198506732]
CTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. [ISBN:0198506732]
lipid transport	biological process	The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [ISBN:0198506732]
nucleoside metabolic process	biological process	The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). [GOC:ma]