Compounds > 2-meoemate
Page last updated: 2024-11-11

2-meoemate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID9842809
CHEMBL ID372231
SCHEMBL ID307890
MeSH IDM0359144

Synonyms (10)

Synonym
2-meoemate
CHEMBL372231 ,
(8r,9s,13s,14s)-2-methoxy-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3-sulfonic acid amide
bdbm50171450
2-methoxyestrrone-3-o-sulfamate
SCHEMBL307890
BTQHAWWINOTNQQ-QPWUGHHJSA-N
2-methoxy-17-oxo-estra-1,3,5(10)-trien-3-yl sulfamate
[(8r,9s,13s,14s)-2-methoxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] sulfamate
PD084844
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 2Homo sapiens (human)IC50 (µMol)0.37600.00021.10608.3000AID317983
Steryl-sulfataseHomo sapiens (human)IC50 (µMol)0.04200.00010.40717.6000AID241447
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
steroid catabolic processSteryl-sulfataseHomo sapiens (human)
female pregnancySteryl-sulfataseHomo sapiens (human)
epidermis developmentSteryl-sulfataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
steryl-sulfatase activitySteryl-sulfataseHomo sapiens (human)
sulfuric ester hydrolase activitySteryl-sulfataseHomo sapiens (human)
metal ion bindingSteryl-sulfataseHomo sapiens (human)
arylsulfatase activitySteryl-sulfataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
lysosomeSteryl-sulfataseHomo sapiens (human)
endosomeSteryl-sulfataseHomo sapiens (human)
endoplasmic reticulumSteryl-sulfataseHomo sapiens (human)
endoplasmic reticulum lumenSteryl-sulfataseHomo sapiens (human)
endoplasmic reticulum membraneSteryl-sulfataseHomo sapiens (human)
Golgi apparatusSteryl-sulfataseHomo sapiens (human)
plasma membraneSteryl-sulfataseHomo sapiens (human)
membraneSteryl-sulfataseHomo sapiens (human)
intracellular membrane-bounded organelleSteryl-sulfataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID241447Inhibitory concentration against steroid sulfatase in placental microsomes2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID1249503Growth inhibition of human MCF7 cells at 1 uM2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID1249504Growth inhibition of human LNCAP cells (androgen receptor positive)2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID473851Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay2010Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
AID247409Concentration required to inhibit the growth of MDA-MB-435 human breast cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID1600023Antiproliferative activity against human PC3 cells2019European journal of medicinal chemistry, Oct-01, Volume: 179Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
AID247390Concentration required to inhibit the growth of SF-539 human CNS cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID247389Concentration required to inhibit the growth of HOP-6 human lung cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID473861Displacement of [3H]colchicine from bovine brain tubulin at 5 uM after 10 mins2010Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
AID1249507Growth inhibition of human A2780/ADR2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID247406Concentration required to inhibit the growth of OVCAR-3 human ovarian cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID1600025Antiproliferative activity against human A2780cis cells2019European journal of medicinal chemistry, Oct-01, Volume: 179Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
AID1249505Growth inhibition of human androgen receptor negative PC3 cells2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID247396Inhibition of the growth of human breast cancer MCF-7 cells done for 2 hr at 37 degree C with compound2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID1600026Antiproliferative activity against human A2780/ADR cells2019European journal of medicinal chemistry, Oct-01, Volume: 179Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
AID1249500Growth inhibition of human MCF7 cells2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID473852Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay2010Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
AID1249492Inhibition of STS activity in human placental microsome2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID473860Inhibition of bovine brain tubulin assembly assessed as decrease in turbidity after 20 mins2010Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
AID1600022Antiproliferative activity against human MCF7 cells at 1 uM relative to control2019European journal of medicinal chemistry, Oct-01, Volume: 179Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
AID317983Inhibition of human carbonic anhydrase 22008Journal of medicinal chemistry, Mar-13, Volume: 51, Issue:5
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
AID1600024Antiproliferative activity against human LNCAP cells2019European journal of medicinal chemistry, Oct-01, Volume: 179Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
AID247398Concentration required to inhibit the growth of SN12C human renal cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID247400Concentration required to inhibit the growth of HCT116 human colon cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID244799Mean graph midpoint (MGM) against a panel of human tumor cell lines2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID247405Concentration required to inhibit the growth of DU-145 human prostate cancer cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
AID1249506Growth inhibition of human A2780cisR cells2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
AID247387Concentration required to inhibit the growth of UACC-62 human melanoma cells by 50%2005Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
anastrozole
[no description available]		2.1110nitrile;
triazoles		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
letrozole
[no description available]		2.1110nitrile;
triazoles		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
2-methoxyestradiol
2-methoxy-17beta-estradiol : A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.		2.974017beta-hydroxy steroid;
3-hydroxy steroid		angiogenesis modulating agent;
antimitotic;
antineoplastic agent;
human metabolite;
metabolite;
mouse metabolite
estrone-3-o-sulfamate
estrone-3-O-sulfamate: a steroid sulfatase inhibitor		3.8730
ym 511
YM 511: a non-steroidal aromatase inhibitor; structure given in first source		3.6520
2-methoxyestrone
2-methoxyestrone : A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.		2.021017-oxo steroid;
3-hydroxy steroid;
alicyclic ketone;
aromatic ether;
phenolic steroid;
phenols		human metabolite;
mouse metabolite
fosbretabulin
[no description available]		2.0510stilbenoid
vorozole
vorozole: structure given in first source; vorozole/R 83842 is ((+)/dextro-isomer), RN 129731-10-8; R 83839 ((-)/levo-isomer)		2.1110benzotriazoles
estradiol-3-o-sulfamate
[no description available]		2.4620
2-methoxyestradiol-3,17-o,o-bis(sulfamate)
2-methoxyestradiol-3,17-O,O-bis(sulfamate): an antiangiogenic microtubule disruptor; antineoplastic agent; structure in first source		4.140
4-methylcoumarin 7-o-sulfamate
[no description available]		3.6520
2-ethylestradiol sulfamate
2-ethyloestradiol-bis-sulfamate: structure in first source		3.930
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.1110
Endometrioma
An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.		02.1110
Cancer of Prostate
[description not available]		02.1110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1110
Endometriosis
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.		02.1110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1110