Assay ID | Title | Year | Journal | Article |
AID525194 | Induction of Axin2 in mouse L cell expressing Wnt and STF assessed as decreased beta-casein level by Western blot method | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1655635 | Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated for 20 mins followed by [32P[-NAD+ addition and further incubated for 1 hr by liquid scintillation counte | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
AID1655632 | Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells at 200 uM using histone H3.3 as substrate incubated for 20 mins followed by [32P[-NAD+ addition and further incubated for 1 hr by liquid scintillation | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
AID748264 | Inhibition of 6XHis-tagged tankyrase1 (1091 to 1325) (unknown origin) after 60 mins in presence of NAD | 2013 | Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
| Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. |
AID525450 | Inhibition of caudal fin regeneration after mechanical resection in zebrafish at 10 uM after 7 days | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525197 | Induction of Axin2 stabilization in human DLD1 cells assessed as inhibition of Wnt/beta-casein pathway | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1655630 | Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells at 200 uM using chicken core histone as substrate incubated for 20 mins followed by [32P[-NAD+ addition and further incubated for 1 hr by liquid scinti | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
AID1655633 | Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated for 20 mins followed by [32P[-NAD+ addition and further incubated for 1 hr by liquid scintillation counte | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
AID661307 | Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins by Western blot analysis | 2012 | Journal of medicinal chemistry, Feb-09, Volume: 55, Issue:3
| Structural basis of selective inhibition of human tankyrases. |
AID525451 | Inhibition of Wnt3A mediated fgf20a expression in Zebrafish resected tail fins after 24 hrs post amputation | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1655641 | Inhibition of colony formation in human DLD1 cells at 1 uM incubated for 12 days by crystal violet staining based assay | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. |
AID425205 | Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
| Structure-activity relationship studies of small-molecule inhibitors of Wnt response. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |